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Host–Microbiota Mutualism in Metabolic Diseases

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Fabbiano Salvatore, Suárez-Zamorano Nicolas, Trajkovski Mirko,
Project Metabolic homeostasis through physiological stimulation of beige fat development
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Review article (peer-reviewed)

Journal Frontiers in Endocrinology
Volume (Issue) 8
Page(s) x - x
Title of proceedings Frontiers in Endocrinology
DOI 10.3389/fendo.2017.00267

Open Access

Type of Open Access Publisher (Gold Open Access)


The intestinal microbiota is a plastic ecosystem that is shaped by environmental and genetic factors, interacting with virtually all tissues of the host. Many signals result from the interplay between the microbiota with its mammalian symbiont that can lead to altered metabolism. Disruptions in the microbial composition are associated with a number of comorbidities linked to the metabolic syndrome. Promoting the niche expansion of beneficial bacteria through diet and supplements can improve metabolic disorders. Reintroducing bacteria through probiotic treatment or fecal transplant is a strategy under active investigation for multiple pathological conditions. Here, we review the recent knowledge of microbiota's contribution to host pathology, the modulation of the microbiota by dietary habits, and the potential therapeutic benefits of reshaping the gut bacterial landscape in context of metabolic disorders such as obesity.