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Synthetic microbial assemblages and the dynamic interplay between microbial genotypes

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Dolinsek Jan, Goldschmidt Felix, Johnson David R,
Project Metabolic specialization and the causes of diversity in microbial ecosystems
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Review article (peer-reviewed)

Journal FEMS Microbiology Reviews
Page(s) 961 - 979
Title of proceedings FEMS Microbiology Reviews

Open Access

URL https://academic.oup.com/femsre/article/40/6/961/2399987
Type of Open Access Repository (Green Open Access)

Abstract

Assemblages of microbial genotypes growing together can display surprisingly complex and unexpected dynamics and result in community-level functions and behaviors that are not readily expected from analyzing each genotype in isolation. This complexity has, at least in part, inspired a discipline of synthetic microbial ecology. Synthetic microbial ecology focuses on designing, building and analyzing the dynamic behavior of ‘ecological circuits’ (i.e. a set of interacting microbial genotypes) and understanding how community-level properties emerge as a consequence of those interactions. In this review, we discuss typical objectives of synthetic microbial ecology and the main advantages and rationales of using synthetic microbial assemblages. We then summarize recent findings of current synthetic microbial ecology investigations. In particular, we focus on the causes and consequences of the interplay between different microbial genotypes and illustrate how simple interactions can create complex dynamics and promote unexpected community-level properties. We finally propose that distinguishing between active and passive interactions and accounting for the pervasiveness of competition can improve existing frameworks for designing and predicting the dynamics of microbial assemblages.
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