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Increased decision thresholds enhance information gathering performance in juvenile Obsessive-Compulsive Disorder (OCD).

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Hauser Tobias U, Moutoussis Michael, Iannaccone Reto, Brem Silvia, Walitza Susanne, Drechsler Renate, Dayan Peter, Dolan Raymond J,
Project Neuroimaging of cognitive flexibility and action monitoring in paediatric obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD)
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Original article (peer-reviewed)

Journal PLoS computational biology
Volume (Issue) 13(4)
Page(s) 1005440 - 1005440
Title of proceedings PLoS computational biology
DOI 10.1371/journal.pcbi.1005440

Open Access

URL http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005440
Type of Open Access Publisher (Gold Open Access)

Abstract

Patients with obsessive-compulsive disorder (OCD) can be described as cautious and hesitant, manifesting an excessive indecisiveness that hinders efficient decision making. However, excess caution in decision making may also lead to better performance in specific situations where the cost of extended deliberation is small. We compared 16 juvenile OCD patients with 16 matched healthy controls whilst they performed a sequential information gathering task under different external cost conditions. We found that patients with OCD outperformed healthy controls, winning significantly more points. The groups also differed in the number of draws required prior to committing to a decision, but not in decision accuracy. A novel Bayesian computational model revealed that subjective sampling costs arose as a non-linear function of sampling, closely resembling an escalating urgency signal. Group difference in performance was best explained by a later emergence of these subjective costs in the OCD group, also evident in an increased decision threshold. Our findings present a novel computational model and suggest that enhanced information gathering in OCD can be accounted for by a higher decision threshold arising out of an altered perception of costs that, in some specific contexts, may be advantageous.
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