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Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Dotto G. P., Rustgi A. K.,
Project Cancer stromal cell genetic control
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Original article (peer-reviewed)

Journal Cancer Cell
Volume (Issue) 29
Page(s) 622 - 637
Title of proceedings Cancer Cell


Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell-fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic, and epigenetic studies, and complementary functional analysis. The evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.