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Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS).

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2014
Author Lefaucheur Jean-Pascal, André-Obadia Nathalie, Antal Andrea, Ayache Samar S, Baeken Chris, Benninger David H, Cantello Roberto M, Cincotta Massimo, de Carvalho Mamede, De Ridder Dirk, Devanne Hervé, Di Lazzaro Vincenzo, Filipović Saša R, Hummel Friedhelm C, Jääskeläinen Satu K, Kimiskidis Vasilios K, Koch Giacomo, Langguth Berthold, Nyffeler Thomas, Oliviero Antonio, Padberg Frank, Poulet Emmanuel, Rossi Simone, Rossini Paolo Maria, Rothwell John C,
Project Motion and spatial neglect
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Original article (peer-reviewed)

Journal Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiol
Volume (Issue) 125(11)
Page(s) 2150 - 206
Title of proceedings Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiol
DOI 10.1016/j.clinph.2014.05.021

Abstract

A group of European experts was commissioned to establish guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) from evidence published up until March 2014, regarding pain, movement disorders, stroke, amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, consciousness disorders, tinnitus, depression, anxiety disorders, obsessive-compulsive disorder, schizophrenia, craving/addiction, and conversion. Despite unavoidable inhomogeneities, there is a sufficient body of evidence to accept with level A (definite efficacy) the analgesic effect of high-frequency (HF) rTMS of the primary motor cortex (M1) contralateral to the pain and the antidepressant effect of HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC). A Level B recommendation (probable efficacy) is proposed for the antidepressant effect of low-frequency (LF) rTMS of the right DLPFC, HF-rTMS of the left DLPFC for the negative symptoms of schizophrenia, and LF-rTMS of contralesional M1 in chronic motor stroke. The effects of rTMS in a number of indications reach level C (possible efficacy), including LF-rTMS of the left temporoparietal cortex in tinnitus and auditory hallucinations. It remains to determine how to optimize rTMS protocols and techniques to give them relevance in routine clinical practice. In addition, professionals carrying out rTMS protocols should undergo rigorous training to ensure the quality of the technical realization, guarantee the proper care of patients, and maximize the chances of success. Under these conditions, the therapeutic use of rTMS should be able to develop in the coming years.
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