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Highly oxygenated sesquiterpenes from the aerial parts of Artemisia alba Turra

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author M Todorova A Trendafilova L Evstatieva L Simmons E Wolfram K Danova,
Project PhytoBalk
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Original article (peer-reviewed)

Journal Planta medica
Volume (Issue) 79
Page(s) PI104
Title of proceedings Planta medica
DOI 10.1055/s-0033-1352196


Artemisia alba Turra (Artemisia, Asteraceae) is widespread in the southern and south-eastern parts of Europe – Spain, Italy and Balkan peninsula [1]. The aerial parts of Artemisia alba Turra have been traditionally utilized as a stomach digestive and tonic in the form of a decoction [2]. The literature survey revealed few reports concerning the non-volatile components of this species: santonin, nerolidol derivatives and artalbic acid were isolated from the aerial parts, whereas the roots were shown to contain a sesquiterpene-coumarin ether [3]. The aerial parts of field cultivated Artemisia alba Turra were initially defatted with hexane and then extracted successively with chloroform and methanol. Further CC and PTLC purification of the chloroform extract resulted in the isolation of 10 new compounds with germacrane, oplopane, eudesmane, guaiane and bisabolane carbon skeletons. Their structures were elucidated by NMR spectroscopy (1H-NMR, 1H-1H COSY, HSQC, HMBC, NOESY) and MS. It was found that the isolated compounds are highly oxygenated and contained 2 – 5 oxygen-bearing functions (OH, OOH, and OAc). The main components were germacrane derivatives with C-10 exomethylene group and C-3 and C-9 substituted positions. Additional oxygenated positions were C-1, C-2, C-4 or C-12 carbons. The dominant component among the isolated compounds was 1-hydroperoxy-3-hydroxy-9-acetoxy-germacra-5, 10(14)-diene.