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Free‐running 5D coronary MR angiography at 1.5T using LIBRE water excitation pulses

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Masala Nemanja, Bastiaansen Jessica A. M., Di Sopra Lorenzo, Roy Christopher W., Piccini Davide, Yerly Jérôme, Colotti Roberto, Stuber Matthias,
Project A Paradigm Shift in Magnetic Resonance Imaging of the Heart: 5D Imaging - Sample Now and Ask Questions Later
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Original article (peer-reviewed)

Journal Magnetic Resonance in Medicine
Page(s) mrm.28221 - mrm.28221
Title of proceedings Magnetic Resonance in Medicine
DOI 10.1002/mrm.28221

Open Access

Type of Open Access Green OA Embargo (Freely available via Repository after an embargo)


Purpose To implement, optimize, and characterize lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulses for fat-suppressed fully self-gated free-running 5D cardiac MRI. Methods Bloch equation simulations were used to optimize LIBRE parameter settings in non-interrupted bSSFP prior to in vitro validation. Thus, optimized LIBRE pulses were subsequently applied to free-running coronary MRA in 20 human adult subjects, where resulting images were quantitatively compared to those obtained with non-fat-suppressing excitation (SP), conventional 1-2-1 water excitation (WE), and a previously-published interrupted free-running (IFR) sequence. SAR and scan times were recorded. Respiratory-and-cardiac-motion-resolved images were reconstructed with XD-GRASP, and contrast ratios, coronary artery detection rate, vessel length, and vessel sharpness were computed. Results The numerically-optimized LIBRE parameters were successfully validated in vitro. In vivo, LIBRE had the lowest SAR and a scan time that was similar to that of WE yet 18% shorter than that of IFR. LIBRE improved blood-fat contrast when compared to SP, WE and IFR, vessel detection relative to SP and IFR, and vessel sharpness when compared to WE and IFR (for example, for the left main and anterior descending coronary artery, 51.5% ± 10.2% (LIBRE) vs 42.1% ± 6.8% (IFR)). Vessel length measurements remained unchanged for all investigated methods. Conclusion LIBRE enabled fully self-gated non-interrupted free-running 5D bSSFP imaging of the heart at 1.5T with suppressed fat signal. Measures of image quality, vessel conspicuity, and scan time compared favorably to those obtained with the more conventional non-interrupted WE and the previously-published interrupted free-running IFR, while SAR reduction offers added flexibility.