Back to overview

Atherogenesis in youth - Early consequence of adolescent smoking

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Dratva Julia, Probst-Hensch Nicole M., Schmidt-Trücksäss Arno, Caviezel Seraina, De Groot Eric, Bettschart Robert W., Saleh Lanja, Gapoz Jean Michel, Rothe Thomas, Schindler Christian, Stolz Daiana Prestes, Turk Alexander J., Rochat Thierry S., Kuenzli Nino, Zemp Elisabeth,
Project Preventing viral exacerbation of chronic obstructive pulmonary disease in upper respiratory tract infection - The PREVENT study
Show all

Original article (peer-reviewed)

Journal Atherosclerosis
Volume (Issue) 230(2)
Page(s) 304 - 309
Title of proceedings Atherosclerosis
DOI 10.1016/j.atherosclerosis.2013.08.004


Background: Cigarette smoking is a prevalent risk behavior among adolescents and tracks into adulthood. Little is known on the early impact of smoking on the vasculature in adolescence, although smoking is considered highly atherogenic in adults. We investigated the association between active smoking and Carotid artery Intima Media Thickness (CIMT), an early indicator of atherosclerosis. Methods and results: The SAPALDIA Youth Study is a nested study involving 356 offspring (8-20yrs) of the Swiss SAPALDIA cohort who reported on early life, health and lifestyle, smoking habits and disease history. 288 youth underwent clinical examination. Mean average and maximum CIMT were calculated across all images of right and left common carotid. Multi-level linear regression was performed with weekly smoking, daily number of cigarettes and serum cotinine, adjusting for participant's and parental confounders. Valid CIMT data was available in 275 offspring (mean age 15yrs, 53% girls). Weekly smoking was reported by 10% and current parental smoking by 24%. Individual mean and maximal CIMT averaged to 0.52mm (sd 0.05) and 0.60mm (sd. 0.05), respectively. Regression analyses yielded significant increase in average CIMT (mm) in weekly smokers (0.025, 95% CI 0.006; 0.045), per cigarette/day (0.003, 95% CI 0.001; 0.005) and serum cotinine level (0.008/100μg/l, 95% CI 0.002; 0.015), which remained consistent after adjusting for parental confounders. Conclusion: Our study yields evidence of an early adverse impact of active tobacco exposure on atherogenesis in adolescents, independent of parental smoking, underlining the public health importance of prevention of adolescent smoking. © 2013 Elsevier Ireland Ltd.