Publication

Back to overview

Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2012
Author Blasius A.L., Krebs P., Sullivan B.M., Oldstone M.B., Popkin D.L.,
Project A forward genetic approach to uncover novel molecules required for NK cell function and CD8+ T cell priming
Show all

Original article (peer-reviewed)

Journal PLoS Pathogens
Volume (Issue) 8(9)
Page(s) 1 - 9
Title of proceedings PLoS Pathogens
DOI 10.1371/journal.ppat.1002915

Open Access

Abstract

Plasmacytoid dendritic cells (pDCs) are the major producers of type I IFN in response to viral infection and have been shown to direct both innate and adaptive immune responses in vitro. However, in vivo evidence for their role in viral infection is lacking. We evaluated the contribution of pDCs to acute and chronic virus infection using the feeble mouse model of pDC functional deficiency. We have previously demonstrated that feeble mice have a defect in TLR ligand sensing. Although pDCs were found to influence early cytokine secretion, they were not required for control of viremia in the acute phase of the infection. However, T cell priming was deficient in the absence of functional pDCs and the virus-specific immune response was hampered. Ultimately, infection persisted in feeble mice. We conclude that pDCs are likely required for efficient T cell priming and subsequent viral clearance. Our data suggest that reduced pDC functionality may lead to chronic infection.
-