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Orientation invariant and non-parametric Axon Diameter Distribution mapping using {PGSE} and regularized discrete linear modeling

Type of publication Peer-reviewed
Publikationsform Proceedings (peer-reviewed)
Author Romascano David Paul Roger, Barakovic Muhamed, Auría Rasclosa Anna, Dyrby Tim B., Thiran Jean-Philippe, Daducci Alessandro,
Project Towards micro-structure-based tractography for quantitative brain connectivity analysis
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Proceedings (peer-reviewed)

Title of proceedings Proceedings of the 24th annual meeting of the International Society for Magnetic Resonance in Medicine ({ISMRM})
Place Honolulu, Hawaii, USA


Axon Diameter Distributions (ADDs) change during brain development and are altered in several brain pathologies. Mapping ADDs non-invasively using dMRI could provide a useful biomarker, but existing methods are either parametric, orientation dependent, surmmarize the whole ADD as a single measure or use non-standard protocols. We propose to estimate the ADD from an orientation-invariant PGSE protocol optimized for axon diameter sensitivity, using a discrete linear model with smoothness and sparsity regularization. To our knowledge, we are the first to report orientationally invarant ADD estimates from dMRI data.