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Assessment of bundle-specific axon diameter distributions using diffusion {MRI} tractography

Type of publication Peer-reviewed
Publikationsform Proceedings (peer-reviewed)
Author Barakovic Muhamed, Romascano David Paul Roger, Dyrby Tim B., Alexander Daniel C., Thiran Jean-Philippe, Daducci Alessandro,
Project Towards micro-structure-based tractography for quantitative brain connectivity analysis
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Proceedings (peer-reviewed)

Title of proceedings 22nd Annual Meeting of the Organization for Human Brain Mapping


The main limitation of diffusion tractography for connectivity studies is that the reconstructed tractograms are not truly quantitative. Microstructure imaging allows the estimation of more quantitative features of the neuronal tissue, such as the axon diameter distribution, but this analysis can only be performed voxelwise. Here, we extend a framework that we recently proposed for evaluating the plausibility of tractograms (COMMIT) with the aim of assessing bundle-specific axon diameter distributions as well. This possibility may have implications in connectomics, as it opens new perspectives for investigating brain connectivity at different scales.