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International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Rudolf Daniel, Michaylov Nikolay, van der Linden Mark, Hoy Ludwig, Klugman Keith P, Welte Tobias, Pletz Mathias W, CAPNETZ Study Group,
Project Preventing viral exacerbation of chronic obstructive pulmonary disease in upper respiratory tract infection - The PREVENT study
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Original article (peer-reviewed)

Journal Antimicrobial agents and chemotherapy
Volume (Issue) 55(10)
Page(s) 4915 - 7
Title of proceedings Antimicrobial agents and chemotherapy
DOI 10.1128/aac.00250-11


A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia (CAP) were analyzed. Thirty percent showed a close relationship to international clones and had fitness equal to or exceeding that of other strains (P = 0.015); these factors may result in the endurance of these strains despite a reduction of antibiotic usage.