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Beta-cell mitochondrial carriers and the diabetogenic stress response

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Brun T, Maechler p,
Project Novel avenues in mitochondrial function and diabetes
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Review article (peer-reviewed)

Journal Biochim Biophys Acta
Page(s) 2540
Title of proceedings Biochim Biophys Acta
DOI 10.1016/j.bbamcr.2016.03.012

Abstract

Mitochondria play a central role in pancreatic beta-cells by coupling metabolism of the secretagogue glucose to distal events of regulated insulin exocytosis. This process requires transports of both metabolites and nucleotides in and out of the mitochondria. The molecular identification of mitochondrial carriers and their respective contribution to beta-cell function have been uncovered only recently. In type 2 diabetes, mitochondrial dysfunction is an early event and may precipitate beta-cell loss. Under diabetogenic conditions, characterized by glucotoxicity and lipotoxicity, the expression profile of mitochondrial carriers is selectively modified. This review describes the role of mitochondrial carriers in beta-cells and the selective changes in response to glucolipotoxicity. In particular, we discuss the importance of the transfer of metabolites (pyruvate, citrate, malate, and glutamate) and nucleotides (ATP, NADH, NADPH) for beta-cell function and dysfunction
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