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Microbiota guides insulin trafficking in beta cells.

Type of publication Not peer-reviewed
Publikationsform Review article (non peer-reviewed)
Author Trajkovski Mirko, Stojanovic Ozren,
Project Metabolic homeostasis through physiological stimulation of beige fat development
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Review article (non peer-reviewed)

Journal Cell research
Page(s) x
Title of proceedings Cell research
DOI 10.1038/s41422-019-0200-5

Open Access

URL https://www.nature.com/articles/s41422-019-0200-5
Type of Open Access Publisher (Gold Open Access)

Abstract

Pancreatic beta cells produce insulin on intricate cellular assembly line, but the extent of the gut microbiota involvement was not clear. It emerges that fragments of bacterial cell wall released by lysozyme 1 in the intestinal lumen are necessary to keep the machinery running, acting on the cytosolic peptidoglycan receptor Nod1 in the beta cells to regulate the insulin trafficking and glucose tolerance.
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