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Diagnostic approach to eosinophilic oesophagitis: Pearls and pitfalls

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Schoepfer Alain,
Project Defining clinically meaningful therapeutic endpoints in Eosinophilic Esophagitis
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Original article (peer-reviewed)

Journal Best Practice & Research Clinical Gastroenterology
Volume (Issue) 29(5)
Page(s) 783 - 792
Title of proceedings Best Practice & Research Clinical Gastroenterology
DOI 10.1016/j.bpg.2015.06.014


Eosinophilic oesophagitis (EoE) has first been described a little over 20 years ago. EoE has been defined by a panel of international experts as a "chronic, immune/antigen-mediated, oesophageal disease, characterized clinically by symptoms related to oesophageal dysfunction and histologically by eosinophil-predominant inflammation". A value of ≥ 15 eosinophils has been defined as histologic diagnostic cutoff. Other conditions associated with oesophageal eosinophilia, such as gastro-oesophageal reflux disease (GERD), PPI-responsive oesophageal eosinophilia, or Crohn's disease should be excluded before EoE can be diagnosed. This review highlights the latest insights regarding the diagnosis and differential diagnosis of EoE.