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Enhancing treatment effects by combining continuous theta burst stimulation with smooth pursuit training.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2014
Author Hopfner Simone, Cazzoli Dario, Müri René M, Nef Tobias, Mosimann Urs P, Bohlhalter Stephan, Vanbellingen Tim, Nyffeler Thomas,
Project Motion and spatial neglect
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Original article (peer-reviewed)

Journal Neuropsychologia
Page(s) 2
Title of proceedings Neuropsychologia
DOI 10.1016/j.neuropsychologia.2014.10.018


Continuous theta burst stimulation (cTBS) represents a promising approach in the treatment of neglect syndrom. However, it is not known whether cTBS in conjunction with another technique may enhance the therapeutic effects. In the present sham-controlled study, we aimed to combine cTBS with smooth pursuit training (SPT), another method known to effectively improve neglect symptoms, and to evaluate whether this combination would result in a stronger effect than SPT alone. Eighteen patients with left spatial neglect after right-hemispheric stroke were included in the study and performed a cancellation task on a large 54.6" touchscreen monitor. A sequential application of cTBS and SPT induced a significantly greater improvement of neglect than SPT alone. After the combined application of these two methods, patients detected significantly more targets and their cancellation behaviour presented a significantly greater shift towards the contralesional hemispace. We suggest that a combined, sequential application of cTBS and SPT is a promising new approach to treat neglect.