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Altered structural connectivity in patients with medial temporal lobe epilepsy: A Diffusion Spectrum Imaging and Graph Analysis study

Type of publication Peer-reviewed
Publikationsform Proceedings (peer-reviewed)
Publication date 2012
Author Lemkaddem Alia, Vulliemoz Serge, Griffa Alessandra, Daducci Alessandro, Seeck Margitta, Thiran Jean-Philippe,
Project Fast Global Tractography for Sensitive MR Connectomics
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Proceedings (peer-reviewed)

Title of proceedings The International Society for Magnetic Resonance in Medicine (ISMRM)
Place Melbourne, Australia


In this study we investigated the effect of medial temporal lobe epilepsy (MTLE) on the global characteristics of brain connectivity estimated by topological measures. We used DSI (Diffusion Spectrum Imaging) to construct a connectivity matrix where the nodes represents the anatomical ROIs and the edges are the connections between any pair of ROIs weighted by the mean GFA/FA values. A significant difference was found between the patient group vs control group in characteristic path length, clustering coefficient and small-worldness. This suggests that the MTLE network is less efficient compared to the network of the control group.