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Does superficial fat affect metabolite concentrations determined by MR spectroscopy with water referencing?

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Kyathanahally S. P., Fichtner N. D., Adalid V., Kreis R.,
Project Magnetic resonance techniques to determine metabolite levels: extending scope and clinical robustness
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Original article (peer-reviewed)

Journal NMR in Biomedicine
Volume (Issue) 28(11)
Page(s) 1543 - 1549
Title of proceedings NMR in Biomedicine
DOI 10.1002/nbm.v28.11

Open Access

Type of Open Access Repository (Green Open Access)


It has recently been reported in this journal that local fat depots produce a sizable frequency-dependent signal attenuation in magnetic resonance spectroscopy (MRS) of the brain. If of a general nature, this effect would question the use of internal reference signals for quantification of MRS and the quantitative use of MRS as a whole. Here, it was attempted to verify this effect and pinpoint the potential causes by acquiring data with various acquisition settings, including two field strengths, two MR scanners from different vendors, different water suppression sequences, RF coils, localization sequences, echo times, and lipid/metabolite phantoms. With all settings tested, the reported effect could not be reproduced, and it is concluded that water referencing and quantitative MRS per se remain valid tools under common acquisition conditions.