Back to overview

CPAP as treatment of sleep apnea after stroke: A meta-analysis of randomized trials.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Brill Anne-Kathrin, Horvath Thomas, Seiler Andrea, Camilo Millene, Haynes Alan G, Ott Sebastian R, Egger Matthias, Bassetti Claudio L,
Project Sleep loss and sleep disorders and their impact on the short- and longterm outcome of stroke
Show all

Review article (peer-reviewed)

Journal Neurology
Volume (Issue) 90(14)
Page(s) e1222 - e1230
Title of proceedings Neurology
DOI 10.1212/wnl.0000000000005262


To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) examining the effectiveness of continuous positive airway pressure (CPAP) in stroke patients with sleep disordered breathing (SDB). In a systematic literature search of electronic databases (MEDLINE, Embase, and the Cochrane Library) from 1980 to November 2016, we identified RCTs that assessed CPAP compared to standard care or sham CPAP in adult patients with stroke or TIA with SDB. Mean CPAP use, odds ratios (ORs), and standardized mean differences (SMDs) were calculated. The prespecified outcomes were adherence to CPAP, neurologic improvement, adverse events, new vascular events, and death. = 0.0394) across the studies. Long-term survival was improved with CPAP in 1 trial. CPAP use after stroke is acceptable once the treatment is tolerated. The data indicate that CPAP might be beneficial for neurologic recovery, which justifies larger RCTs.