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Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Boedhoe Premika S W, Schmaal Lianne, Abe Yoshinari, Ameis Stephanie H, Arnold Paul D, Batistuzzo Marcelo C, Benedetti Francesco, Beucke Jan C, Bollettini Irene, Bose Anushree, Brem Silvia, Calvo Anna, Cheng Yuqi, Cho Kang Ik K, Dallaspezia Sara, Denys Damiaan, Fitzgerald Kate D, Fouche Jean-Paul, Giménez Mònica, Gruner Patricia, Hanna Gregory L, Hibar Derrek P, Hoexter Marcelo Q, Hu Hao, Huyser Chaim, Ikari Keisuke, Jahanshad Neda, Kathmann Norbert, Kaufmann Christian, Koch Kathrin, Kwon Jun Soo, Lazaro Luisa, Liu Yanni, Lochner Christine, Marsh Rachel, Martínez-Zalacaín Ignacio, Mataix-Cols David, Menchón José M, Minuzzi Luciano, Nakamae Takashi, Nakao Tomohiro, Narayanaswamy Janardhanan C, Piras Fabrizio, Piras Federica, Pittenger Christopher, Reddy Y C Janardhan, Sato Joao R, Simpson H Blair, Soreni Noam, Soriano-Mas Carles, Spalletta Gianfranco, Stevens Michael C, Szeszko Philip R, Tolin David F, Venkatasubramanian Ganesan, Walitza Susanne, Wang Zhen, van Wingen Guido A, Xu Jian, Xu Xiufeng, Yun Je-Yeon, Zhao Qing, Zhao Qing, Thompson Paul M, Stein Dan J, van den Heuvel Odile A,
Project Neuroimaging of cognitive flexibility and action monitoring in paediatric obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD)
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Original article (peer-reviewed)

Journal The American journal of psychiatry
Volume (Issue) 174(1)
Page(s) 60 - 69
Title of proceedings The American journal of psychiatry
DOI 10.1176/appi.ajp.2016.16020201


Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.