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Virus-associated activation of innate immunity induces rapid disruption of Peyer's patches in mice.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Heidegger Simon, Anz David, Stephan Nicolas, Bohn Bernadette, Herbst Tina, Fendler Wolfgang Peter, Suhartha Nina, Sandholzer Nadja, Kobold Sebastian, Hotz Christian, Eisenächer Katharina, Radtke-Schuller Susanne, Endres Stefan, Bourquin Carole,
Project Immunotherapy of gastric cancer: Enhancing T cell recruitment into tumors
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Original article (peer-reviewed)

Journal Blood
Volume (Issue) 122(15)
Page(s) 2591 - 9
Title of proceedings Blood
DOI 10.1182/blood-2013-01-479311

Abstract

Early in the course of infection, detection of pathogen-associated molecular patterns by innate immune receptors can shape the subsequent adaptive immune response. Here we investigate the influence of virus-associated innate immune activation on lymphocyte distribution in secondary lymphoid organs. We show for the first time that virus infection of mice induces rapid disruption of the Peyer's patches but not of other secondary lymphoid organs. The observed effect was not dependent on an active infectious process, but due to innate immune activation and could be mimicked by virus-associated molecular patterns such as the synthetic double-stranded RNA poly(I:C). Profound histomorphologic changes in Peyer's patches were associated with depletion of organ cellularity, most prominent among the B-cell subset. We demonstrate that the disruption is entirely dependent on type I interferon (IFN). At the cellular level, we show that virus-associated immune activation by IFN-α blocks B-cell trafficking to the Peyer's patches by downregulating expression of the homing molecule α4β7-integrin. In summary, our data identify a mechanism that results in type I IFN-dependent rapid but reversible disruption of intestinal lymphoid organs during systemic viral immune activation. We propose that such rerouted lymphocyte trafficking may impact the development of B-cell immunity to systemic viral pathogens.
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