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Current concepts in eosinophilic esophagitis

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Simon Dagmar, Straumann Alex, Schoepfer Alain M., Simon Hans-Uwe,
Project Defining clinically meaningful therapeutic endpoints in Eosinophilic Esophagitis
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Original article (peer-reviewed)

Journal Allergo Journal International
Volume (Issue) 26(7)
Page(s) 258 - 266
Title of proceedings Allergo Journal International
DOI 10.1007/s40629-017-0037-8

Open Access

URL http://doi.org/10.1007/s40629-017-0037-8
Type of Open Access Publisher (Gold Open Access)

Abstract

Background: Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration. Methods: This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE. Results: EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T‑helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described. Conclusion: Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.
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