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The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Radman Narges, Mouthon Michael, Di Pietro Marie, Gaytanidis Chrisovalandou, Leemann Beatrice, Abutalebi Jubin, Annoni Jean-Marie,
Project Role of executive functions on language: an experimental and clinical approach with application to mother language and second language
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Original article (peer-reviewed)

Journal Neural Plasticity
Volume (Issue) 2016
Page(s) 1 - 22
Title of proceedings Neural Plasticity
DOI 10.1155/2016/8797086

Open Access

URL http://doi.org/10.1155/2016/8797086
Type of Open Access Publisher (Gold Open Access)

Abstract

Aphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we collected behavioral measures of language production (general aphasia evaluation and picture naming) in each language and language control (linguistic and nonlinguistic switching tasks), as well as fMRI during a naming task at one and four months following stroke in five bilingual patients suffering from poststroke aphasia. We further applied dynamic causal modelling (DCM) analyses to the connections between language and control brain areas. Three patients showed parallel recovery in language production, one patient improved in L1, and one improved in L2 only. Language-control functions improved in two patients. Consistent with the dynamic view of language recovery, DCM analyses showed a higher connectedness between language and control areas in the language with the better recovery. Moreover, similar degrees of connectedness between language and control areas were found in the patients who recovered in both languages. Our data suggest that engagement of the interconnected language-control network is crucial in the recovery of languages.
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