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Temporally Dissociable Contributions of Human Medial Prefrontal Subregions to Reward-Guided Learning.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Hauser Tobias U, Hunt Laurence T, Iannaccone Reto, Walitza Susanne, Brandeis Daniel, Brem Silvia, Dolan Raymond J,
Project Neuroimaging of cognitive flexibility and action monitoring in paediatric obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD)
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Original article (peer-reviewed)

Journal The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume (Issue) 35(32)
Page(s) 11209 - 20
Title of proceedings The Journal of neuroscience : the official journal of the Society for Neuroscience
DOI 10.1523/jneurosci.0560-15.2015

Open Access

URL http://www.jneurosci.org/content/35/32/11209
Type of Open Access Publisher (Gold Open Access)

Abstract

In decision making, dorsal and ventral medial prefrontal cortex show a sensitivity to key decision variables, such as reward prediction errors. It is unclear whether these signals reflect parallel processing of a common synchronous input to both regions, for example from mesocortical dopamine, or separate and consecutive stages in reward processing. These two perspectives make distinct predictions about the relative timing of feedback-related activity in each of these regions, a question we address here. To reconstruct the unique temporal contribution of dorsomedial (dmPFC) and ventromedial prefrontal cortex (vmPFC) to simultaneously measured EEG activity in human subjects, we developed a novel trialwise fMRI-informed EEG analysis that allows dissociating correlated and overlapping sources. We show that vmPFC uniquely contributes a sustained activation profile shortly after outcome presentation, whereas dmPFC contributes a later and more peaked activation pattern. This temporal dissociation is expressed mainly in the alpha band for a vmPFC signal, which contrasts with a theta based dmPFC signal. Thus, our data show reward-related vmPFC and dmPFC responses have distinct time courses and unique spectral profiles, findings that support distinct functional roles in a reward-processing network. Multiple subregions of the medial prefrontal cortex are known to be involved in decision making and learning, and expose similar response patterns in fMRI. Here, we used a novel approach to analyzing simultaneous EEG-fMRI that allows to dissociate the individual time courses of brain regions. We find that vmPFC and dmPFC have distinguishable time courses and time-frequency patterns.
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