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5D Flow MRI: A Fully Self-gated, Free-running Framework for Cardiac and Respiratory Motion–resolved 3D Hemodynamics

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Ma Liliana E., Yerly Jérôme, Piccini Davide, Di Sopra Lorenzo, Roy Christopher W., Carr James C., Rigsby Cynthia K., Kim Daniel, Stuber Matthias, Markl Michael,
Project A Paradigm Shift in Magnetic Resonance Imaging of the Heart: 5D Imaging - Sample Now and Ask Questions Later
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Original article (peer-reviewed)

Journal Radiology: Cardiothoracic Imaging
Volume (Issue) 2(6)
Page(s) e200219 - e200219
Title of proceedings Radiology: Cardiothoracic Imaging
DOI 10.1148/ryct.2020200219

Abstract

Summary A free-running fully self-gated five-dimensional flow MRI framework was introduced and validated in vitro and in vivo; results demonstrated that this technique can consistently and reliably capture respiratory- driven effects on cardiovascular flow in less than 8 minutes. Key Points n A fully self-gated free-running five-dimensional (5D) flow MRI framework for acquisition and evaluation of cardiac and respiratory motion–resolved three-dimensional hemodynamics was implemented and validated. n Whole-heart 5D flow data were collected in all participants in 7.65 minutes 6 0.35 (acceleration rate = 36.0–76.9) versus 9.88 minutes 6 3.17 for conventional four-dimensional (4D) flow of the thoracic aorta (P , .05). n In vitro validations in a pulsatile phantom suggest good agreement (within 7%) between conventional 4D flow and 5D flow, whereas in vivo respiratory-resolved analyses suggested that peak velocities and flows increase in the superior vena cava and decrease in the inferior vena cava at end inspiration compared with end expiration.
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