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Mitochondrial pyruvate import and its effects on homeostasis

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Vanderperre B,
Project Novel avenues in mitochondrial function and diabetes
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Review article (peer-reviewed)

Journal Curr Opin Cell Biol
Page(s) 35
Title of proceedings Curr Opin Cell Biol
DOI 10.1016/j.ceb.2014.10.008

Abstract

Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.
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