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Latest Insights on the Relationship Between Symptoms and Biologic Findings in Adults with Eosinophilic Esophagitis

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Safroneeva Ekaterina, Straumann Alex, Schoepfer Alain M.,
Project Defining clinically meaningful therapeutic endpoints in Eosinophilic Esophagitis
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Original article (peer-reviewed)

Journal Gastrointestinal Endoscopy Clinics of North America
Volume (Issue) 28(1)
Page(s) 35 - 45
Title of proceedings Gastrointestinal Endoscopy Clinics of North America
DOI 10.1016/j.giec.2017.08.001

Abstract

Patients with eosinophilic esophagitis (EoE) present with symptoms accompanied by behavioral adaptions to living with this condition. These include swallowing- and nonswallowing-associated pain in adulthood. In children, EoE symptoms vary with age and include vomiting, abdominal pain, and dysphagia. Studies using validated patient-reported outcome measures have demonstrated that symptoms in EoE are associated with severe biologic alterations and that patients on the low biologic severity spectrum have few symptoms. This nonlinear nature of the relationship between symptoms and biologic findings has important implications for among other things the length of diagnostic delay, selection of patients for clinical trials, trial duration, and long-term management of EoE patients.
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