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Decision-Making in Multiple Sclerosis Patients: A Systematic Review

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Neuhaus Mireille, Calabrese Pasquale, Annoni Jean-Marie,
Project Role of executive functions on language: an experimental and clinical approach with application to mother language and second language
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Original article (peer-reviewed)

Journal Multiple Sclerosis International
Volume (Issue) 2018
Page(s) 1 - 9
Title of proceedings Multiple Sclerosis International
DOI 10.1155/2018/7835952

Open Access

Type of Open Access Publisher (Gold Open Access)


Background . Multiple sclerosis (MS) is frequently associated with cognitive and behavioural deficits. A growing number of studies suggest an impact of MS on decision-making abilities. The aim of this systematic review was to assess if (1) performance of MS patients in decision-making tasks was consistently different from controls and (2) whether this modification was associated with cognitive dysfunction and emotional alterations. Methods . The search was conducted on Pubmed/Medline database. 12 studies evaluating the difference between MS patients and healthy controls using validated decision-making tasks were included. Outcomes considered were quantitative (net scores) and qualitative measurements (deliberation time and learning from feedback). Results . Quantitative and qualitative decision-making impairment in MS was present in 64.7% of measurements. Patients were equally impaired in tasks for decision-making under risk and ambiguity. A correlation to other cognitive functions was present in 50% of cases, with the highest associations in the domains of processing speed and attentional capacity. Conclusions . In MS patients, qualitative and quantitative modifications may be present in any kind of decision-making task and can appear independently of other cognitive measures. Since decision-making abilities have a significant impact on everyday life, this cognitive aspect has an influential importance in various MS-related treatment settings.