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Toward a Comprehensive Strategy to Mitigate Dissemination of Environmental Sources of Antibiotic Resistance

Publikationsart Peer-reviewed
Publikationsform Originalbeitrag (peer-reviewed)
Autor/in Vikesland Peter J., Pruden Amy, Alvarez Pedro J. J., Aga Diana, Bürgmann Helmut, Li Xiang-dong, Manaia Celia M., Nambi Indumathi, Wigginton Krista, Zhang Tong, Zhu Yong-Guan,
Projekt Swiss River Resistome - identity, fate, and exposure
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Originalbeitrag (peer-reviewed)

Zeitschrift Environmental Science & Technology
Volume (Issue) 51(22)
Seite(n) 13061 - 13069
Titel der Proceedings Environmental Science & Technology
DOI 10.1021/acs.est.7b03623

Open Access

Abstract

Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.
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