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All together now: Analogies between chimera state collapses and epileptic seizures.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Andrzejak Ralph G, Rummel Christian, Mormann Florian, Schindler Kaspar,
Project A Bayesian Inference Approach to Intracranial EEG Seizure Dynamics
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Original article (peer-reviewed)

Journal Scientific reports
Volume (Issue) 6
Page(s) 23000 - 23000
Title of proceedings Scientific reports
DOI 10.1038/srep23000

Open Access

URL http://www.nature.com/articles/srep23000
Type of Open Access Publisher (Gold Open Access)

Abstract

Conceptually and structurally simple mathematical models of coupled oscillator networks can show a rich variety of complex dynamics, providing fundamental insights into many real-world phenomena. A recent and not yet fully understood example is the collapse of coexisting synchronous and asynchronous oscillations into a globally synchronous motion found in networks of identical oscillators. Here we show that this sudden collapse is promoted by a further decrease of synchronization, rather than by critically high synchronization. This strikingly counterintuitive mechanism can be found also in nature, as we demonstrate on epileptic seizures in humans. Analyzing spatiotemporal correlation profiles derived from intracranial electroencephalographic recordings (EEG) of seizures in epilepsy patients, we found a pronounced decrease of correlation at the seizure onsets. Applying our findings in a closed-loop control scheme to models of coupled oscillators in chimera states, we succeed in both provoking and preventing outbreaks of global synchronization. Our findings not only advance the understanding of networks of coupled dynamics but can open new ways to control them, thus offering a vast range of potential new applications.
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