Lead


Lay summary
Venous thromboembolism (VTE), defined as a clot in the deep leg veins or in the arteries of the pulmonary circulation, is common and has a high impact on morbidity, mortality, and costs of care. Sixty-four percent of patients with VTE are aged 65 years or more, making VTE essentially a disease of the elderly. Despite the significant public health impact of VTE in the elderly and the fact that VTE may have a less favourable course in elderly patients, older patients are underrepresented in existing studies of VTE, and little is known about the factors that determine medical outcomes, quality of life, and costs of care in the elderly. The broad objective of this multicenter, interdisciplinary prospective cohort study is to determine the predictors of clinically relevant medical outcomes, health-related quality of life, and medical resource utilizatio among elderly patients with VTE. Overall, 993 consecutive inpatients and outpatients aged 65 years or more with a diagnosis of VTE will be prospectively enrolled at 9 Swiss university and non-university hospitals and followed for up to 4 years. Successful completion of this project will provide important insight in factors that drive medical outcomes, health-related quality of life, and health resource utilization among elderly patients with VTE. Our findings will have value to doctors who are committed to optimizing patient outcomes and providing high-quality, cost-effective care.