Lead


Lay summary
DNA molecules change their structure during such vital processes like DNA replication, DNA recombination, DNA repair or DNA transcription. Understanding these functional transitions of DNA structure helps to elucidate molecular mechanisms involved in normal and pathological situations like for example in patients with defective DNA repair. Long term aim of this project is to catalogue various functional DNA structures and to understand the effect of such factors like nucleotide sequence, DNA supercoiling, counterion concentration, mutagens and therapeutic drugs on affecting these functional transitions of DNA structure.