Project

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Development of sleep regulation - a window of opportunity for fostering healthy development

Applicant Kurth Salomé
Number 181279
Funding scheme Eccellenza
Research institution Département de Psychologie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Psychology
Start/End 01.09.2019 - 31.08.2024
Approved amount 1'839'353.00
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All Disciplines (2)

Discipline
Psychology
Neurophysiology and Brain Research

Keywords (15)

cognitive development; sleep regulation; infant sleep; gut microbiome; brain development; high density EEG; gut-brain axis; sleep intervention; early marker; neurodevelopment; sleep neurophysiology; slow wave activity; electroencephalography; 16S rRNA; circadian rhythm

Lay Summary (German)

Lead
Entwicklung der Schlafregulation - ein Zeitfenster zur Förderung einer gesunden EntwicklungGuter Schlaf ist für unsere Gesundheit von grundlegender Bedeutung, denn er fördert unsere Hirnfunktion und kognitive Leistungsfähigkeit. Im letzten Jahrzehnt wurde unser Verständnis von „Schlaf als Verhaltenszustand” zum „Schlaf als neurophysiologischem Erholungsprozess” verschoben. Wir verstehen zunehmend, dass Schlaf mit Prozessen der Hirnreifung verknüpft ist: Die Hirnaktivität im Tiefschlaf-Elektroenzephalogramm widerspiegelt Hirnreifungsprozesse. Zudem stehen Schlafprobleme im Kindesalter mit späteren kognitiven oder regulatorischen Schwierigkeiten in Verbindung.
Lay summary

Inhalt und Ziele des Forschungsprojekts

Bekannt ist, dass Darmbakterien unsere Genexpression beeinflussen. Es gibt nun auch erste Hinweise, dass Schlaf mit den Darmbakterien verknüpft ist. Nicht ausreichend untersucht ist jedoch, ob die Bakterien den Schlaf regulieren. Das übergeordnete Ziel unserer Forschung ist das Verständnis des Schlafes bezüglich kognitiver Entwicklung und Darmbakterien. 

Wir werden das Schlaf-Wach-Verhalten der Neurophysiologie des Schlafs gegenüberstellen. Die Ernährung und eine Schlafintervention werden dabei untersucht. Wir werden Schlaf im ungeborenen Kind beobachten, Einflüsse von Antibiotika, sowie Mutter-Kind Interaktionen in den ersten Lebensmonaten untersuchen.

 

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts

Das Projekt ist interdisziplinär, mit Ansätzen aus Neurowissenschaften und Mikrobiologie. Unsere Arbeit generiert Grundlagen über die Rolle des Schlafs. Das visionäre Ziel ist die Förderung guter Schlafqualität und alters-entsprechender Schlafregulation, sowie des gesunden Verlaufs der kognitiven Entwicklung. 

  

 

 

 

 

Direct link to Lay Summary Last update: 20.06.2019

Responsible applicant and co-applicants

Employees

Publications

Publication
Sleep behavior of infants with infantile hemangioma treated with propranolol—a cohort study
Theiler Martin, Knöpfel Nicole, von der Heydt Susanne, Schwieger-Briel Agnes, Luchsinger Isabelle, Smith Alexandra, Kernland-Lang Kristin, Waelchli Regula, Neuhaus Kathrin, Kohler Malcolm, Gnannt Ralph, Schoch Sarah F., Weibel Lisa, Kurth Salome (2021), Sleep behavior of infants with infantile hemangioma treated with propranolol—a cohort study, in European Journal of Pediatrics, 0.
Severe Effects of the COVID-19 Confinement on Young Children’s Sleep: A Longitudinal Study Identifying Risk Factors and Protective Arrangements
Markovic Andjela, Mühlematter Christophe, Beaugrand Matthieu, Camos Valerie, Kurth Salome (2021), Severe Effects of the COVID-19 Confinement on Young Children’s Sleep: A Longitudinal Study Identifying Risk Factors and Protective Arrangements, in Journal of Sleep Research, 1.
Altered EEG markers of synaptic plasticity in a human model of NMDA receptor deficiency: anti-NMDA receptor encephalitis
SR Gefferie, A Maric, H Critelli, S Gueden, G Kurlemann, S Kurth, M Nosadini, B Plecko, M Ringli, K Rostásy, S Sartori, B Schmitt, A Suppiej, BK Bölsterli (2021), Altered EEG markers of synaptic plasticity in a human model of NMDA receptor deficiency: anti-NMDA receptor encephalitis, in NeuroImage, xxx.
Association of transportation noise with sleep during the first year of life: A longitudinal study.
C Blume, SF Schoch, D Vienneau, M Röösli, M Kohler, A Moeller, S Kurth, J Usemann (2021), Association of transportation noise with sleep during the first year of life: A longitudinal study., in Environmental research, xxx.
Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study.
M Theiler, N Knöpfel, von der Heydt S, A Schwieger-Briel, I Luchsinger, A Smith, K Kernland-Lang, R Waelchli, K Neuhaus, M Kohler, R Gnannt, S Kurth (2021), Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study., in European journal of pediatrics, xxx.
Actigraphy in sleep research with infants and young children: Current practices and future benefits of standardized reporting
Schoch Sarah F., Kurth Salome, Werner Helene (2020), Actigraphy in sleep research with infants and young children: Current practices and future benefits of standardized reporting, in Journal of Sleep Research, 1-15.
Spatio-temporal properties of sleep slow waves and implications for development
Timofeev Igor, Schoch Sarah F, LeBourgeois Monique K, Huber Reto, Riedner Brady A, Kurth Salome (2020), Spatio-temporal properties of sleep slow waves and implications for development, in Current Opinion in Physiology, 15, 172-182.
Characterization of overnight slow-wave slope changes across development in an age-, amplitude-, and region-dependent manner.
V Jaramillo, C Volk, A Maric, M Furrer, S Fattinger, S Kurth, C Lustenberger, R Huber (2020), Characterization of overnight slow-wave slope changes across development in an age-, amplitude-, and region-dependent manner., in Sleep, 10.1093/sl.
The experience-dependent increase in deep sleep activity is reduced in children with attention-deficit/hyperactivity disorder
Furrer Melanie, Ringli Maya, Kurth Salome, Brandeis Daniel, Jenni Oskar G., Huber Reto (2020), The experience-dependent increase in deep sleep activity is reduced in children with attention-deficit/hyperactivity disorder, in Sleep Medicine, 75, 50-53.
Which are the central aspects of infant sleep? The dynamic of sleep composites across infancy
SchochSarah, HuberReto, KohlerMalcolm, KurthSalome (2020), Which are the central aspects of infant sleep? The dynamic of sleep composites across infancy, in Sensors, 20(24), 7188.
Actimetry in infant sleep research: an approach to facilitate comparability.
SF Schoch, OG Jenni, M Kohler, S Kurth (2019), Actimetry in infant sleep research: an approach to facilitate comparability., in Sleep, xxx.
Endocrine responses during CPAP withdrawal in obstructive sleep apnoea: data from two randomised controlled trials.
S Thiel, SR Haile, M Peitzsch, EI Schwarz, NA Sievi, S Kurth, F Beuschlein, M Kohler, T Gaisl (2019), Endocrine responses during CPAP withdrawal in obstructive sleep apnoea: data from two randomised controlled trials., in Thorax, 10.1136/th.

Collaboration

Group / person Country
Types of collaboration
Prof. Sean Deoni, Memorial Hospital of Rhode Island United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Steven Brown, Pharmacology & Toxicology, University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Christophe Lacroix and Dr. Jean-Claude Walser, ETH Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Monique LeBourgeois, University of Colorado Boulder United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Dirk Bassler and Dr. Giancarlo Natalucci, University Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof. Oskar Jenni, Child Development Center, University Children's Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Prof. Reto Huber, Sleep Laboratory, University Children's Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Björn Rasch and Prof. Valerie Camos, University of Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Walter Karlen, Robotics, ETH Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Yuko Munakata, University of Colorado Boulder United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Dennis Nielsen, Institut of Food Science, University of Copenhagen Denmark (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Congress of the European Sleep Research Society (ESRS) Talk given at a conference Slow oscillations in children and their potential as neurodevelopmental marker 20.09.2020 Sevilla - dann virtuell, Spain Kurth Salomé;
Symposium of the Genetic Diversity Center, ETH, Zurich Talk given at a conference On the search of how sleep regulation develops in the first year of human life: Does the gut microbiome play a role? 10.09.2020 Zurich, ETH (dann aber virtuell), Switzerland Kurth Salomé;
Lunchtime Seminar, Dept of Psychology, University of Fribourg Individual talk Maturation of sleep rhythm in children: Investigating its function and risks 28.11.2019 Fribourg, Switzerland Kurth Salomé;
SECMED Neurobiology Seminars, University of Fribourg Individual talk Sleep regulation in early life – a window of opportunity for development 25.09.2019 Fribourg, Switzerland Kurth Salomé;


Self-organised

Title Date Place

Knowledge transfer events

Communication with the public

Communication Title Media Place Year
Video/Film Baby Sleep Lab Research Project International 2021
New media (web, blogs, podcasts, news feeds etc.) [Laufender BLOG in English, Deutsch, Französisch] Baby Sleep Lab Science BLOG International 2020
Media relations: print media, online media Experiment Lockdown: Auch in Sachen Schlaf. Alma&Georges, Online Magazine of the University of Fribourg Western Switzerland 2020
Media relations: print media, online media Kinder schlafen anders Universitas, Magazin Universität Fribourg Western Switzerland German-speaking Switzerland 2020
Media relations: print media, online media L’enfant a un autre sommeil. La Gruyère Western Switzerland 2020
Media relations: print media, online media Le sommeil des enfants est différent du nôtre Medienmitteilung, Universität Fribourg International 2020
Media relations: print media, online media Researchers from the Baby Sleep Laboratory call for methodological standardization Twitter International 2020
Talks/events/exhibitions Pint of Science in Oliver Twist Pub, Zurich: Babies, Bedtimes and Bacteria German-speaking Switzerland 2019

Abstract

Good sleep is essential to human health, as it fosters neuronal functioning, cognitive performance and decision-making. Empirical work in the past decade has caused a shift in view from sleep as a pure behavior towards sleep as localized neurophysiological and cellular recovery process. Sleep also interacts with neurodevelopment - a connotation that opens up new avenues for interventional studies. Importantly, bacterial symbionts partially regulate the gene expression landscape of the human host. First indications suggest that bacteria are also linked to host sleep regulation. Mechanisms physiologically underlying the sleep-bacteria link were proposed to include peripheral circadian synchronization, the sleep hormone melatonin or neurotrophic/ neuroendocrine pathways. This project aims to foster the understanding of the role of sleep and especially also bacterial symbionts in cognitive development. We hypothesize that:(1) sleep quality is influenced by bacteria in infants,(2) sleep-wake behavior is associated with neurophysiological (EEG) maturational markers, and(3) neurophysiological maturational markers are associated with cognitive development. With a nutritional monitoring and a sleep intervention we will explore the link between of bacteria and infant sleep regulation. Associations will further be tested in a clinical population of preterm-born infants, and further, effects of antibiotic exposure will be quantified. With a behavioral sleep intervention, we will explore effects of improved sleep on bacteria and cognition. To capture the development of sleep-wake regulation, sleep will be objectively assessed in a core cohort of mother-infant pairs, starting in pregnancy. We will investigate the association of sleep-wake behavior with neuronal maturational markers (sleep high density EEG) and with cognitive development. The project at the edge of neuroscience, psychology and microbiology and the use of novel approaches tackling the early human lifespan has the immediate goal to examine the role of the bacteria-sleep link in infant development and the visionary goal to improve cognitive development by fostering healthy sleep regulation in infants.
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