cognitive development; sleep regulation; infant sleep; gut microbiome; brain development; high density EEG; gut-brain axis; sleep intervention; early marker; neurodevelopment; sleep neurophysiology; slow wave activity; electroencephalography; 16S rRNA; circadian rhythm
Theiler Martin, Knöpfel Nicole, von der Heydt Susanne, Schwieger-Briel Agnes, Luchsinger Isabelle, Smith Alexandra, Kernland-Lang Kristin, Waelchli Regula, Neuhaus Kathrin, Kohler Malcolm, Gnannt Ralph, Schoch Sarah F., Weibel Lisa, Kurth Salome (2021), Sleep behavior of infants with infantile hemangioma treated with propranolol—a cohort study, in European Journal of Pediatrics
Markovic Andjela, Mühlematter Christophe, Beaugrand Matthieu, Camos Valerie, Kurth Salome (2021), Severe Effects of the COVID-19 Confinement on Young Children’s Sleep: A Longitudinal Study Identifying Risk Factors and Protective Arrangements, in Journal of Sleep Research
SR Gefferie, A Maric, H Critelli, S Gueden, G Kurlemann, S Kurth, M Nosadini, B Plecko, M Ringli, K Rostásy, S Sartori, B Schmitt, A Suppiej, BK Bölsterli (2021), Altered EEG markers of synaptic plasticity in a human model of NMDA receptor deficiency: anti-NMDA receptor encephalitis, in NeuroImage
C Blume, SF Schoch, D Vienneau, M Röösli, M Kohler, A Moeller, S Kurth, J Usemann (2021), Association of transportation noise with sleep during the first year of life: A longitudinal study., in Environmental research
M Theiler, N Knöpfel, von der Heydt S, A Schwieger-Briel, I Luchsinger, A Smith, K Kernland-Lang, R Waelchli, K Neuhaus, M Kohler, R Gnannt, S Kurth (2021), Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study., in European journal of pediatrics
Schoch Sarah F., Kurth Salome, Werner Helene (2020), Actigraphy in sleep research with infants and young children: Current practices and future benefits of standardized reporting, in Journal of Sleep Research
Timofeev Igor, Schoch Sarah F, LeBourgeois Monique K, Huber Reto, Riedner Brady A, Kurth Salome (2020), Spatio-temporal properties of sleep slow waves and implications for development, in Current Opinion in Physiology
, 15, 172-182.
V Jaramillo, C Volk, A Maric, M Furrer, S Fattinger, S Kurth, C Lustenberger, R Huber (2020), Characterization of overnight slow-wave slope changes across development in an age-, amplitude-, and region-dependent manner., in Sleep
Furrer Melanie, Ringli Maya, Kurth Salome, Brandeis Daniel, Jenni Oskar G., Huber Reto (2020), The experience-dependent increase in deep sleep activity is reduced in children with attention-deficit/hyperactivity disorder, in Sleep Medicine
, 75, 50-53.
SchochSarah, HuberReto, KohlerMalcolm, KurthSalome (2020), Which are the central aspects of infant sleep? The dynamic of sleep composites across infancy, in Sensors
, 20(24), 7188.
SF Schoch, OG Jenni, M Kohler, S Kurth (2019), Actimetry in infant sleep research: an approach to facilitate comparability., in Sleep
S Thiel, SR Haile, M Peitzsch, EI Schwarz, NA Sievi, S Kurth, F Beuschlein, M Kohler, T Gaisl (2019), Endocrine responses during CPAP withdrawal in obstructive sleep apnoea: data from two randomised controlled trials., in Thorax
Good sleep is essential to human health, as it fosters neuronal functioning, cognitive performance and decision-making. Empirical work in the past decade has caused a shift in view from sleep as a pure behavior towards sleep as localized neurophysiological and cellular recovery process. Sleep also interacts with neurodevelopment - a connotation that opens up new avenues for interventional studies. Importantly, bacterial symbionts partially regulate the gene expression landscape of the human host. First indications suggest that bacteria are also linked to host sleep regulation. Mechanisms physiologically underlying the sleep-bacteria link were proposed to include peripheral circadian synchronization, the sleep hormone melatonin or neurotrophic/ neuroendocrine pathways. This project aims to foster the understanding of the role of sleep and especially also bacterial symbionts in cognitive development. We hypothesize that:(1) sleep quality is influenced by bacteria in infants,(2) sleep-wake behavior is associated with neurophysiological (EEG) maturational markers, and(3) neurophysiological maturational markers are associated with cognitive development. With a nutritional monitoring and a sleep intervention we will explore the link between of bacteria and infant sleep regulation. Associations will further be tested in a clinical population of preterm-born infants, and further, effects of antibiotic exposure will be quantified. With a behavioral sleep intervention, we will explore effects of improved sleep on bacteria and cognition. To capture the development of sleep-wake regulation, sleep will be objectively assessed in a core cohort of mother-infant pairs, starting in pregnancy. We will investigate the association of sleep-wake behavior with neuronal maturational markers (sleep high density EEG) and with cognitive development. The project at the edge of neuroscience, psychology and microbiology and the use of novel approaches tackling the early human lifespan has the immediate goal to examine the role of the bacteria-sleep link in infant development and the visionary goal to improve cognitive development by fostering healthy sleep regulation in infants.