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Water-Soluble Arene Ruthenium Complexes

English title Water-Soluble Arene Ruthenium Complexes
Applicant Süss-Fink Georg
Number 131844
Funding scheme Project funding (Div. I-III)
Research institution Laboratoire de chimie des organométalliques et de catalyse moléculaire Université de Neuchâtel
Institution of higher education University of Neuchatel - NE
Main discipline Inorganic Chemistry
Start/End 01.10.2010 - 30.09.2012
Approved amount 242'020.00
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Keywords (9)

Dinuclear complexes; Trinuclear clusters; Hexanuclear cages; Catalysis; Water-soluble organometallics; Ruthenium; Anticancer properties; Arene ruthenium cages; Anti-cancer properties

Lay Summary (English)

Lead
Lay summary
LeadThe present research project focuses on the synthesis and structural characterization of new di- and multinuclear arene ruthenium complexes that are soluble in water and inert towards hydrolysis, with the aim of exploiting their inherent catalytic or biological potential. BackgroundAlthough being the cheapest of all noble metals, ruthenium has almost no industrial application and was only scarcely used in catalytic reactions, until the discovery of highly enantioselective ruthenium-based hydrogenation catalysts by R. Noyori and of efficient ruthenium-based olefin metathesis catalysts by R. H. Grubbs. These two major discoveries led to the Nobel prizes of 2001 and 2005 and also stimulated the coordination chemistry of ruthenium. AimWithin this project, we propose to work on two main topics involving two Ph. D. students: Dinuclear Arene Ruthenium Complexes with Thiolato and Selenolato Bridges as well as Arene Ruthenium Cages with Various Tritopic Connecting Units.SignificanceWhile water-soluble organometallics in general are still very rare, arene ruthenium complexes with this particular property, the chemistry of which we have pioneered, open new perspectives for use as catalysts in aqueous solution and as potential anti-cancer drugs.KeywordsRuthenium, Dinuclear complexes, Trinuclear clusters, Arene ruthenium cages, Catalysis, Water-soluble organometallics, Anti-cancer properties
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Highly Cytotoxic Trithiophenolato Diruthenium Complexes of the Type [(η6-p-MeC6H4Pri)2Ru2(SC6H4-p-X)3]+: Synthesis, Molecular Structure, Electrochemistry, Cytotoxicity and Glutathione Oxidation Pote
Giannini F., Furrer J., Ibao A.-F., Zava O., Baquie M., Dyson P. J., Therrien B., Süss-Fink G., Stepnicka P. (2012), Highly Cytotoxic Trithiophenolato Diruthenium Complexes of the Type [(η6-p-MeC6H4Pri)2Ru2(SC6H4-p-X)3]+: Synthesis, Molecular Structure, Electrochemistry, Cytotoxicity and Glutathione Oxidation Pote, in Journal of Biological Inorgenic Chemistry, 17, 951-960.
Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers
Schmitt F., Freudenreich J., Barry N. P. E., Juillerat-Jeanneret L., Süss-Fink G., Therrien B. (2011), Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers, in Journal of the American Chemical Society, 134, 754-757.
Thiolato-Bridged Dinuclear Arene Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2(SR)2Cl2]
Ibao A.-F., Gras M., Therrien B., Süss-Fink G., Zava O., Dyson P. J. (2011), Thiolato-Bridged Dinuclear Arene Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2(SR)2Cl2], in European Journal of Inorganic Chemistry, 2012, 1531-1525.
Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Arene Ruthenium Trithiolato Anticancer Complex
Giannini F., Süss-Fink G., Furrer J. (2011), Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Arene Ruthenium Trithiolato Anticancer Complex, in Inorganic Chemistry, 50, 10552-10554.
Arene ruthenium bis-saccharinato complexes: Synthesis, molecular structure and catalytic oxidation properties in aqueous solution
Thai T-T, Therrien B, Süss-Fink G (2011), Arene ruthenium bis-saccharinato complexes: Synthesis, molecular structure and catalytic oxidation properties in aqueous solution, in Journal of Organometallic Chemistry, 696(21), 3285-3291.
Template-directed synthesis of hexanuclear arene ruthenium complexes with trigonal-prismatic architecture based on 2,4,6-tris(3-pyridyl)triazine ligands
Freudenreich J, Furrer J, Süss-Fink G, Therrien B (2011), Template-directed synthesis of hexanuclear arene ruthenium complexes with trigonal-prismatic architecture based on 2,4,6-tris(3-pyridyl)triazine ligands, in Organometallics, 30(5), 942-951.
Thiophenolato-bridged dinuclear arene ruthenium complexes: A new family of highly cytotoxic anticancer agents
Gras M, Therrien B, Süss-Fink G, Zava O, Dyson PJ (2010), Thiophenolato-bridged dinuclear arene ruthenium complexes: A new family of highly cytotoxic anticancer agents, in Dalton Transactions, 39(42), 10305-10313.

Associated projects

Number Title Start Funding scheme
139078 1.7 mm Micro-Probehead for small volume NMR Spectroscopic Investigations 01.03.2012 R'EQUIP
143254 Water-Soluble Ruthenium Complexes and Nanoparticles for Catalysis and Tumor Targeting 01.01.2013 Project funding (Div. I-III)
143254 Water-Soluble Ruthenium Complexes and Nanoparticles for Catalysis and Tumor Targeting 01.01.2013 Project funding (Div. I-III)
121509 Water-Soluble Arene Ruthenium Complexes 01.10.2008 Project funding (Div. I-III)

Abstract

The present research project focuses on the synthesis and structural characterization of new multinuclear arene ruthenium complexes that are soluble in water and inert towards hydrolysis, with the aim of exploiting their inherent catalytic properties and their biological potential. While water-soluble organometallics in general are still very rare, arene ruthenium complexes with this particular property, the chemistry of which we have pioneered, open new perspectives for use as catalysts in aqueous solution and as potential anti-cancer drugs. This research proposal is a follow-up project of the ongoing project no 200020-121'509, which has proven to be successful and promising, although one of the three topics of the previous proposal (Bimetallic Arene Ruthenium-Tin Complexes) has come to an end. While it was possible to synthesize the target complexes and to study their structure and their chemistry, these compounds did not show the expected catalytic properties. In general, as far as the potential applications are concerned, the previous project has shown that the biological properties of water-soluble arene ruthenium complexes have become more important than the catalytic properties. Within this project, we propose to work on three main topics involving three Ph. D. students: Trinuclear Arene Ruthenium Clusters with Biologically Active Substitutents (Anne-Flore IBAO, 1 year), Arene Ruthenium Cages with Various Tritopic Connecting Units (Julien FREUDENREICH, 2 years) and Dinuclear Arene Ruthenium Complexes with Thiolato and Selenolato Bridges (N. N., 2 years).
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