cohort; socioeconomic status; DNA methylation; gene expression
Fiorito Giovanni, Polidoro Silvia, Dugué Pierre-Antoine, Kivimaki Mika, Ponzi Erica, Matullo Giuseppe, Guarrera Simonetta, Assumma Manuela B, Georgiadis Panagiotis, Kyrtopoulos Soterios A, Krogh Vittorio, Palli Domenico, Panico Salvatore, Sacerdote Carlotta, Tumino Rosario, Chadeau-Hyam Marc, Stringhini Silvia, Severi Gianluca, Giles Graham G, Marioni Riccardo, Karlsson Linnér Richard, O'Halloran Aisling M, Kenny Rose A, Layte Richard, Baglietto Laura, Robinson Oliver, McCrory Cathal, Milne Roger L, Vineis Paolo (2017), Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation., in Scientific reports
, 7(1), 16266-16266.
Cheval Boris, Sieber Stefan, Guessous Idris, Orsholits Dan, Courvoisier Delphine S, Kliegel Matthias, Stringhini Silvia, Swinnen Stephan P, Burton-Jeangros Claudine, Cullati Stéphane, Boisgontier Matthieu P (2017), Effect of Early- and Adult-Life Socioeconomic Circumstances on Physical Inactivity., in Medicine and science in sports and exercise
de Mestral Carlos, Stringhini Silvia (2017), Socioeconomic Status and Cardiovascular Disease: an Update., in Current cardiology reports
, 19(11), 115-115.
Alves Luís, Stringhini Silvia, Barros Henrique, Azevedo Ana, Marques-Vidal Pedro (2017), Inequalities in obesity in Portugal: regional and gender differences., in European journal of public health
, 27(4), 775-780.
Stringhini Silvia, Zaninotto Paola, Kumari Meena, Kivimäki Mika, Lassale Camille, David Batty G (2017), Socio-economic trajectories and cardiovascular disease mortality in older people: the English Longitudinal Study of Ageing., in International journal of epidemiology
d’Errico Angelo, Ricceri Fulvio, Stringhini Silvia, Carmeli Cristian, Kivimaki Mika, Bartley Mel, McCrory Cathal, Bochud Murielle, Vollenweider Peter, Tumino Rosario, Goldberg Marcel, Zins Marie, Barros Henrique, Giles Graham, Severi Gianluca, Costa Giuseppe, Vineis Paolo (2017), Socioeconomic indicators in epidemiologic research: A practical example from the LIFEPATH study, in PLOS ONE
, 12(5), e0178071-e0178071.
de Mestral Carlos, Mayén Ana-Lucia, Petrovic Dusan, Marques-Vidal Pedro, Bochud Murielle, Stringhini Silvia (2017), Socioeconomic Determinants of Sodium Intake in Adult Populations of High-Income Countries: A Systematic Review and Meta-Analysis., in American journal of public health
, 107(4), 563-563.
de Mestral Carlos, Khalatbari-Soltani Saman, Stringhini Silvia, Marques-Vidal Pedro (2017), Fifteen-year trends in the prevalence of barriers to healthy eating in a high-income country., in The American journal of clinical nutrition
, 105(3), 660-668.
Stringhini Silvia, Bovet Pascal (2017), Socioeconomic status and risk factors for non-communicable diseases in low-income and lower-middle-income countries.
, 5(3), 230-231, Lancet Global Health, London 5(3), 230-231.
Stringhini Silvia, Carmeli Cristian, Jokela Markus, Avendaño Mauricio, Muennig Peter, Guida Florence, Ricceri Fulvio, d'Errico Angelo, Barros Henrique, Bochud Murielle, Chadeau-Hyam Marc, Clavel-Chapelon Françoise, Costa Giuseppe, Delpierre Cyrille, Fraga Silvia, Goldberg Marcel, Giles Graham G, Krogh Vittorio, Kelly-Irving Michelle, Layte Richard, Lasserre Aurélie M, Marmot Michael G, Preisig Martin, Shipley Martin J, et al. (2017), Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women, in The Lancet
, 389(10075), 1229-1237.
Mayén Ana-Lucia, de Mestral Carlos, Zamora Gerardo, Paccaud Fred, Marques-Vidal Pedro, Bovet Pascal, Stringhini Silvia (2017), Interventions promoting healthy eating as a tool for reducing social inequalities in diet in low- and middle-income countries: a systematic review., in International journal for equity in health
, 15(1), 205-205.
Mwinyi Jessica, Pisanu Claudia, Castelao Enrique, Stringhini Silvia, Preisig Martin, Schiöth Helgi B (2016), Anxiety Disorders are Associated with Low Socioeconomic Status in Women but Not in Men., in Women's health issues : official publication of the Jacobs Institute of Women's Health
, 27(3), 302-307.
Mayén Ana-Lucia, Guessous Idris, Paccaud Fred, Stringhini Silvia, Marques-Vidal Pedro (2016), Educational differences in dietary intake and compliance with dietary recommendations in a Swiss adult population., in International journal of public health
, 61(9), 1059-1067.
Mayén Ana-Lucia, Bovet Pascal, Marti-Soler Helena, Viswanathan Bharathi, Gedeon Jude, Paccaud Fred, Marques-Vidal Pedro, Stringhini Silvia (2016), Socioeconomic Differences in Dietary Patterns in an East African Country: Evidence from the Republic of Seychelles., in PloS one
, 11(5), 0155617-0155617.
Mayén Ana-Lucia, Stringhini Silvia, Ford Nicole D, Martorell Reynaldo, Stein Aryeh D, Paccaud Fred, Marques-Vidal Pedro (2016), Socioeconomic predictors of dietary patterns among Guatemalan adults., in International journal of public health
, 61(9), 1069-1077.
Castagné Raphaële, Kelly-Irving Michelle, Campanella Gianluca, Guida Florence, Krogh Vittorio, Palli Domenico, Panico Salvatore, Sacerdote Carlotta, Tumino Rosario, Kleinjans Jos, de Kok Theo, Kyrtopoulos Soterios A, Lang Thierry, Stringhini Silvia, Vermeulen Roel, Vineis Paolo, Delpierre Cyrille, Chadeau-Hyam Marc (2016), Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome., in Scientific reports
, 6, 38705-38705.
Stringhini Silvia, Forrester Terrence E, Plange-Rhule Jacob, Lambert Estelle V, Viswanathan Bharathi, Riesen Walter, Korte Wolfgang, Levitt Naomi, Tong Liping, Dugas Lara R, Shoham David, Durazo-Arvizu Ramon A, Luke Amy, Bovet Pascal (2016), The social patterning of risk factors for noncommunicable diseases in five countries: evidence from the modeling the epidemiologic transition study (METS)., in BMC public health
, 16, 956-956.
Social inequalities in health are a ubiquitous phenomenon. Conversely, research still has to provide a comprehensive understanding of the mechanisms underlying them. In the last years, research started addressing the issue of how socioeconomic status eventually “gets under the skin”. Human and animal studies have identified several interrelated processes through which the social environment could be embedded, including dysregulation of the hypothalamic-pituitary-adrenal axis, inflammatory processes, neural function and structure, and, ultimately, epigenetic mechanisms. These studies cover a promising new field of research, and several questions remain to be addressed: 1.Studies examining the biology of social adversity have generally described socioeconomic differences in biological markers, but the actual contribution of these intermediate steps to social inequalities in chronic diseases has rarely been evaluated. Further, few studies have evaluated the interactions between lifestyle-related risk factors and biological markers. 2.Some new lifestyle factors potentially implicated in the etiology of socioeconomic differences in health, such as inadequate sleep, have been under-researched. 3.The influence of early life vs. adult socioeconomic status on the biological pathways leading to diseases remains unknown, as well as the extent to which the impact of early life exposure to social adversity can be modified later in life. This research project will focus on cardio-metabolic disorders, which show a strong gradient in their social distribution and whose burden on the most disadvantaged sections of society is rapidly increasing worldwide. The overarching aim is to extend the study of social inequalities in health and their determinants by incorporating an analysis of the biological mechanisms, and gene regulation in particular, linking lifetime social adversity to cardio-metabolic disease. This follow-up project will be specifically devoted to the study of the relationship between socioeconomic status and gene regulation.This research project will assess: 1)Whether SES in early life is associated with DNA methylation and gene expression, and in which regions of the genome these differences appear; 2)To what extent SES differences in DNA methylation and gene expression contribute to explain SES differences in inflammatory activity; 3)If duration of exposure to low SES and SES trajectories over the lifecourse have an impact on DNA methylation and gene expression. This research project will provide a better understanding of the social and biological pathways leading from lifetime socioeconomic adversity to adult life cardio-metabolic disease risk. This will not only add further observations on the role of exposure in early life in shaping health through adulthood, but will also clarify to what extent exposure to early life social adversity has an impact on adult health through behavioural vs. biological pathways. Moreover, this research will establish the extent to which the undesirable health consequences of adverse social exposure in early life are potentially reversible. Last but not least, an epigenome-wide analysis of socioeconomic differences in gene regulation will allow new insight to be gained into the mechanisms through which the social environment has an impact on health. Information on epigenome-wide gene expression and DNA methylation will be collected in a subsample of 750 participants of the SKIPOGH II study. The multidisciplinarity (social epidemiology, cardiovascular, cardio-metabolic and genetic epidemiology, public health, sleep medicine, internal medicine, and molecular biology) characterizing this research project offers potential to produce novel and innovative answers to the question of how socioeconomic status over the lifecourse leads to disease decades later.