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Entwicklung und Funktion von motorischen Netzwerken

English title Development and function of motor circuits
Applicant Arber Silvia
Number 160339
Funding scheme Project funding (Div. I-III)
Research institution Abteilung Zellbiologie Biozentrum Universität Basel
Institution of higher education University of Basel - BS
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2015 - 31.03.2018
Approved amount 930'000.00
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Keywords (3)

Neuronal circuits; Mouse genetics; Motor control

Lay Summary (German)

Lead
Obwohl fast alle Aktivitäten des Nervensystems zu Bewegungsänderungen führen, weiss man derzeit noch sehr wenig darüber, wie Netzwerke von Nervenzellen diese Bewegungen steuern und beeinflussen. Ziel unserer Forschung ist es deshalb, die Organisation und Funktion neuronaler Netzwerke zu ergründen, welche die Bewegungen des Körpers kontrollieren. Dieses Projekt leistet dazu einen Beitrag.
Lay summary

In diesem Projekt werden wir ergründen, wie die motorischen neuronalen Netzwerke im Rückenmark verknüpft sind und funktionieren. Wir werden dazu genetische und molekulare Kriterien anwenden, um die vielen funktionell verschiedenen Nervenzelltypen zu klassifizieren. Wir werden ausserdem untersuchen, was für einen Einfluss sensorische Rückkoppelung aus den Muskeln auf die Funktion des Rückenmarks hat. Diese Arbeiten werden dazu beitragen, Prinzipien über die Organisation von neuronalen Netzwerken und deren Funktionen aufzudecken. Wir erwarten, dass diese Erkenntnisse auch wichtige Einsichten darüber liefern werden, wie sich diese neuronalen Netzwerke bei Rückenmarkverletzungen umorganisieren und zur Wiederherstellung von Funktion führen können.

 

Direct link to Lay Summary Last update: 14.12.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
Locomotor speed control circuits in the caudal brainstem.
Capelli Paolo, Pivetta Chiara, Soledad Esposito Maria, Arber Silvia (2017), Locomotor speed control circuits in the caudal brainstem., in Nature, 551(7680), 373-377.
Columnar-Intrinsic Cues Shape Premotor Input Specificity in Locomotor Circuits.
Baek Myungin, Pivetta Chiara, Liu Jeh-Ping, Arber Silvia, Dasen Jeremy S (2017), Columnar-Intrinsic Cues Shape Premotor Input Specificity in Locomotor Circuits., in Cell reports, 21(4), 867-877.
A V0 core neuronal circuit for inspiration.
Wu Jinjin, Capelli Paolo, Bouvier Julien, Goulding Martyn, Arber Silvia, Fortin Gilles (2017), A V0 core neuronal circuit for inspiration., in Nature communications, 8(1), 544-544.
Organization and function of neuronal circuits controlling movement.
Arber Silvia (2017), Organization and function of neuronal circuits controlling movement., in EMBO molecular medicine, 9(3), 281-284.
Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability.
Ruder Ludwig, Takeoka Aya, Arber Silvia (2016), Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability., in Neuron, 92(5), 1063-1078.
A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.
Fleming Michael S, Li Jian J, Ramos Daniel, Li Tong, Talmage David A, Abe Shin-Ichi, Arber Silvia, Luo Wenqin (2016), A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles., in The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(40), 10337-10355.
Midbrain circuits for defensive behaviour.
Tovote Philip, Esposito Maria Soledad, Botta Paolo, Chaudun Fabrice, Fadok Jonathan P, Markovic Milica, Wolff Steffen B E, Ramakrishnan Charu, Fenno Lief, Deisseroth Karl, Herry Cyril, Arber Silvia, Lüthi Andreas (2016), Midbrain circuits for defensive behaviour., in Nature, 534(7606), 206-12.
Motor Control: Illuminating an Enigmatic Midbrain Locomotor Center.
Esposito Maria S, Arber Silvia (2016), Motor Control: Illuminating an Enigmatic Midbrain Locomotor Center., in Current biology : CB, 26(7), 291-3.
Context-Dependent Gait Choice Elicited by EphA4 Mutation in Lbx1 Spinal Interneurons.
Satoh Daisuke, Pudenz Christiane, Arber Silvia (2016), Context-Dependent Gait Choice Elicited by EphA4 Mutation in Lbx1 Spinal Interneurons., in Neuron, 89(5), 1046-58.
Multisensory Signaling Shapes Vestibulo-Motor Circuit Specificity.
Basaldella Emanuela, Takeoka Aya, Sigrist Markus, Arber Silvia (2015), Multisensory Signaling Shapes Vestibulo-Motor Circuit Specificity., in Cell, 163(2), 301-12.
Optogenetics: 10 years after ChR2 in neurons-views from the community.
Adamantidis Antoine, Arber Silvia, Bains Jaideep S, Bamberg Ernst, Bonci Antonello, Buzsáki György, Cardin Jessica A, Costa Rui M, Dan Yang, Goda Yukiko, Graybiel Ann M, Häusser Michael, Hegemann Peter, Huguenard John R, Insel Thomas R, Janak Patricia H, Johnston Daniel, Josselyn Sheena A, Koch Christof, Kreitzer Anatol C, Lüscher Christian, Malenka Robert C, Miesenböck Gero, Nagel Georg, Roska Botond, Schnitzer Mark J, Shenoy Krishna V, Soltesz Ivan, Sternson Scott M, Tsien Richard W, Tsien Roger Y, Turrigiano Gina G, Tye Kay M, Wilson Rachel I (2015), Optogenetics: 10 years after ChR2 in neurons-views from the community., in Nature neuroscience, 18(9), 1202-12.
Distinct limb and trunk premotor circuits establish laterality in the spinal cord.
Goetz Cyrill, Pivetta Chiara, Arber Silvia (2015), Distinct limb and trunk premotor circuits establish laterality in the spinal cord., in Neuron, 85(1), 131-44.

Collaboration

Group / person Country
Types of collaboration
Karl-Klaus Conzelmann / Gene Ctr, Ludwig-Maximilians-University Munich Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Wenqin Luo / University of Pennsylvania Perelman School of Medicine United States of America (North America)
- Publication
Andreas Lüthi / Friedrich Miescher Institute for Biomedical Research Switzerland (Europe)
- Publication
Martyn Goulding / Systems Neurobiology, Salk Institute for Biological Studies United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Gilles Fortin / Paris-Saclay Institute of Neuroscience France (Europe)
- Publication
Fan Wang / Duke Institute for Brain Sciences, Duke University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Pico Caroni / Friedrich Miescher Institute for Biomedical Research Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Jeremy Dasen / NYU Neuroscience Institute, New York University School of Medicine United States of America (North America)
- Publication
Botond Roska / Friedrich Miescher Institute for Biomedical Research Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Ed Callaway / Systems Neurobiology, Salk Institute for Biological Studies United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
GRC Basal Ganglia 2018 - Mechanisms Underlying Basal Ganglia Function and Dysfunction Talk given at a conference Organization and function of descending motor circuits 11.03.2018 Ventura, CA, United States of America Arber Silvia; Neves Ferreira Pinto Manuel;
2017 ASCB | EMBO Meeting Talk given at a conference Circuits for Movement 02.12.2017 Philadelphia, PA, United States of America Arber Silvia;
EMBO at Basel Life 2017 Talk given at a conference Organization and Function of Circuits Controlling Motor Behavior - Plenary Lecture 10.09.2017 Basel, Switzerland Arber Silvia;
13th International Congress of the Polish Neuroscience Society – Plenary Presidential Lecture Talk given at a conference Organization and function of descending motor control circuits 28.08.2017 Warsaw, Poland Arber Silvia;
EMBO|EMBL Symposium: Neural circuits in the past, present and future Talk given at a conference Disentangling descending circuits for motor control 14.07.2017 EMBL, Heidelberg, Germany Arber Silvia;
FENS-IBRO Cajal Advanced Training Programme – course: Interacting with neural circuits Talk given at a conference Analysis of motor system organization and function 02.07.2017 Champalimaud Centre for the Unknown, Lisbon, Portugal Arber Silvia;
2017 GRC: Excitatory Transmission and Brain Function - Keynote Session Talk given at a conference Organization and function of descending motor control circuits 28.05.2017 Les Diablerets, Switzerland Arber Silvia;
Society for Neuroscience (SfN): Neuroscience 2016 - Special Lecture Talk given at a conference Circuits for Movement 12.11.2016 San Diego, United States of America Arber Silvia;
SFN Satellite Meeting - Cell Symposium 2016: Big Questions in Neuroscience Talk given at a conference Disentangling descending circuits for motor control 10.11.2016 San Diego, United States of America Arber Silvia;
UCLA Seminar: 2016-2017 Joint Seminars in Neuroscience lecture series Individual talk Disentangling neuronal circuits for motor control 08.11.2016 University of California, Los Angeles, United States of America Arber Silvia;
2016 Louis-Jeantet Symposium: The Future of Developmental Biology Individual talk Disentangling neuronal circuits for motor control 12.10.2016 Geneva, Switzerland Arber Silvia;
Nobel Forum - The Neuroscience Network at Karolinska Institute Symposium: Motor neurons and their networks in health and disease Individual talk Connectivity and function of motor circuits 09.09.2016 Nobel Forum, Stockholm, Sweden Arber Silvia;
FENS Forum 2016 in Copenhagen - Plenary lecture Talk given at a conference Circuits for Movement 02.07.2016 Copenhagen, Denmark Arber Silvia; Ruder Ludwig;
Pasteur Neuroscience Seminar Series Individual talk Organization and function of circuits for motor behavior 10.06.2016 Paris, France Arber Silvia;
Duke University: Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease Individual talk Disentangling neuronal circuits for motor control 13.05.2016 Durham, NC, United States of America Arber Silvia;
NTNU Invited Lecture Individual talk Disentangling neuronal circuits for motor control 31.03.2016 Trondheim, Norway Arber Silvia;
EMBL Monterotondo Distinguished Scientists Seminar Series Individual talk Disentangling neuronal circuits for motor control 22.03.2016 EMBL Monterotondo, Rome, Italy Arber Silvia;
2015 Remedios Caro Almela Lecture Individual talk Disentangling neuronal circuits for motor control 30.10.2015 Alicante, Spain Arber Silvia;
EMBO: 2015 Arolla Workshop on: Cell and Developmental Systems Talk given at a conference Circuits for Motor Behaviors 10.08.2015 Arolla, Switzerland Arber Silvia;
Scientific Symposium for Carmen Birchmeier’s 60th Birthday – MDC Berlin Talk given at a conference Specificity and modules in circuits for motor control 10.07.2015 Berlin, Germany Arber Silvia;
National Neuroscience Societies of the Nordic countries: Nordic Neuroscience 2015 - Plenary Lecture Talk given at a conference Disentangling descending circuits for motor control 10.06.2015 Trondheim, Norway Arber Silvia;
Champalimaud Centre for the Unknown: CNP Colloquium Individual talk Specificity and modules in circuits for motor control 21.05.2015 Lisbon, Portugal Arber Silvia;
Jahrestagung der deutschsprachigen Gesellschaft für Neuropädiatrie (GNP) Talk given at a conference The role of sensory feedback in motor recovery after spinal cord injury 23.04.2015 Basel, Switzerland Arber Silvia;


Self-organised

Title Date Place
Janelia Motor Control Meeting: Motor Control Circuits: Structure, Function and Behavior 09.05.2016 Janelia Research Campus, Ashburn, Va, United States of America
Gatsby Conference Series : The Assembly and Function of Neuronal Circuits 2015 27.09.2015 Monte Verità, Ascona, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Youtube report: https://www.youtube.com/watch?v=L2FNh4NJq1s Performances, exhibitions (e.g. for education institutions) 06.03.2018 Basel, Switzerland Arber Silvia;
Rotary Club Basel - Dreiländereck Talk 23.01.2018 Basel, Switzerland Arber Silvia;
Youtube report: Silvia Arber, Winner of the 2017 Louis-Jeantet Prize for Medicine Performances, exhibitions (e.g. for education institutions) 27.04.2017 Basel, Switzerland Ruder Ludwig; Arber Silvia;


Awards

Title Year
2018 Pradel Research Award (National Academy of Sciences) 2018
2017 Louis-Jeantet Prize for Medicine 2017
J.C.W. Shepherd PhD Student Prize 2017 2017
Novartis VIVA Leading Scientist Award 2017
Remedios Caro Almela Prize in Developmental Neurobiology 2015

Associated projects

Number Title Start Funding scheme
179403 Brainstem Circuits Controlling Movement 01.04.2018 Project funding (Div. I-III)
140625 Entwicklung und Funktion von motorischen Netzwerken 01.04.2012 Project funding (Div. I-III)
140625 Entwicklung und Funktion von motorischen Netzwerken 01.04.2012 Project funding (Div. I-III)

Abstract

The aim of our research is to unravel the organization and function of neuronal circuits controlling motor behavior. Movement is the common behavioral output of all CNS activity, yet how different movement patterns emerge and are regulated at the level of precisely connected neuronal circuits in an animal is currently poorly understood. In the BoE extension of my current SNF grant, we would like to exploit how motor output pathways orchestrate the precise control of motor output regulation in the spinal cord in intact animals, and how this process is influenced by sensory feedback circuits from muscles. This work lays the foundation for a research direction addressing how these identified neuronal circuit elements respond to spinal cord injury. We are convinced that together, these experiments will help to reveal general principles governing neuronal circuit organization at the level of identified neuronal subpopulations involved in motor control, as well as determine the factors influencing motor circuit reorganization after injury.
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