inflammation and cancer; cancer immunotolerance; asbestos; YAP signaling; molecular epidemiology; mesothelioma development; hedgehog signaling; calretinin and calcium transduction; developmental pathways and cancer
Wu Licun, Blum Walter, Zhu Chang-Qi, Yun Zhihong, Pecze Laszlo, Kohno Mikihiro, Chan Mei-Lin, Zhao Yidan, Felley-Bosco Emanuela, Schwaller Beat, de Perrot Marc (2018), Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma, in
BMC Cancer, 18(1), 471-471.
Bachas Costa, Hodzic Jasmina, van der Mijn Johannes C., Stoepker Chantal, Verheul Henk M. W., Wolthuis Rob M. F., Felley-Bosco Emanuela, van Wieringen Wessel N., van Beusechem Victor W., Brakenhoff Ruud H., de Menezes Renée X. (2018), Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection, in
BMC Bioinformatics, 19(1), 301-301.
Wörthmüller Janine, Oberson Anne, Salicio Valérie, Blum Walter, Schwaller Beat (2018), Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca2+-Binding Proteins Calbindin-D28k and Parvalbumin, in
International Journal of Molecular Sciences, 19(12), 4015-4015.
Blum Walter, Henzi Thomas, Châtel-Soulet Hugues-Etienne, Pecze Laszlo, Rodriguez Janine Wörthmüller, Vrugt Bart, Schwaller Beat (2018), Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2+/− mice and mouse mesothelioma cell lines from various mouse strains, in
Biomarker Research, 6(1), 19-19.
Wörthmüller Janine, Blum Walter, Pecze Laszlo, Salicio Valérie, Schwaller Beat (2018), Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway, in
Oncotarget, 9(91), 1-10.
Felley-Bosco Emanuela, MacFarlane Marion (2018), Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials, in
Chemical Research in Toxicology, 31(10), 994-1008.
Rehrauer Hubert, Wu Licun, Blum Walter, Pecze Lazslo, Henzi Thomas, Serre-Beinier Véronique, Aquino Catherine, Vrugt Bart, de Perrot Marc, Schwaller Beat, Felley-Bosco Emanuela (2018), How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations, in
Oncogene, 37(20), 2645-2659.
Kresoja-Rakic Jelena, Felley-Bosco Emanuela (2018), Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells, in
Journal of Visualized Experiments, (134), 1-10.
Felley-Bosco Emanuela, Rehrauer Hubert (2018), Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice, in
International Journal of Molecular Sciences, 19(4), 1163-1163.
Rimann Markus (2018), ZHAW Waedenswil: A new Approach in the Fight against Cancer, in
CHIMIA International Journal for Chemistry, 72(3), 166-168.
Oehl Kathrin, Kresoja-Rakic Jelena, Opitz Isabelle, Vrugt Bart, Weder Walter, Stahel Rolf, Wild Peter, Felley-Bosco Emanuela (2018), Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression, in
Frontiers in Oncology, 8, 1-10.
Blum Walter, Pecze László, Felley-Bosco Emanuela, Worthmüller-Rodriguez Janine, Wu Licun, Vrugt Bart, de Perrot Marc, Schwaller Beat (2017), Erratum to: Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line, in
In Vitro Cellular & Developmental Biology - Animal, 53(9), 853-853.
Schürch Christian M., Forster Stefan, Brühl Frido, Yang Sara H., Felley-Bosco Emanuela, Hewer Ekkehard (2017), The “don't eat me” signal CD47 is a novel diagnostic biomarker and potential therapeutic target for diffuse malignant mesothelioma, in
OncoImmunology, 7(1), e1373235-e1373235.
Parrotta Rossella, Okonska Agata, Ronner Manuel, Weder Walter, Stahel Rolf, Penengo Lorenza, Felley-Bosco Emanuela (2017), A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair, in
Journal of Thoracic Oncology, 12(8), 1309-1319.
Kresoja-Rakic Jelena, Sulemani Merve, Kirschner Michaela B., Ronner Manuel, Reid Glen, Kao Steven, Schwaller Beat, Weder Walter, Stahel Rolf A., Felley-Bosco Emanuela (2017), Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma, in
Frontiers in Genetics, 8, 1-10.
Blum Walter, Pecze László, Felley-Bosco Emanuela, Wu Licun, de Perrot Marc, Schwaller Beat (2017), Stem Cell Factor-Based Identification and Functional Properties of In Vitro-Selected Subpopulations of Malignant Mesothelioma Cells, in
Stem Cell Reports, 8(4), 1005-1017.
Wu Licun, Allo Ghassan, John Thomas, Li Ming, Tagawa Tetsuzo, Opitz Isabelle, Anraku Masaki, Yun Zhihong, Pintilie Melania, Pitcher Bethany, Liu Geoffrey, Feld Ron, Johnston Michael R., de Perrot Marc, Tsao Ming-Sound (2017), Patient-Derived Xenograft Establishment from Human Malignant Pleural Mesothelioma, in
Clinical Cancer Research, 23(4), 1060-1067.
Blum Walter, Pecze Laszlo, Felley-Bosco Emanuela, Wu Licun, de Perrot Marc, Schwaller Beat (2017), Stem cell factors-based identification and functional properties of in vitro-selected subpopulations of malignant mesothelioma cells, in
Stem Cell Reports.
Meerang Mayura, Bérard Karima, Felley-Bosco Emanuela, Lauk Olivia, Vrugt Bart, Boss Andreas, Kenkel David, Broggini-Tenzer Angela, Stahel Rolf A, Arni Stephan, Weder Walter, Opitz Isabelle (2016), Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma., in
Molecular cancer therapeutics, 15(5), 1095-105.
Kresoja-Rakic Jelena, Kapaklikaya Esra, Ziltener Gabriela, Dalcher Damian, Santoro Raffaella, Christensen Brock C, Johnson Kevin C, Schwaller Beat, Weder Walter, Stahel Rolf, Felley-Bosco Emanuela (2016), Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells, in
Oncotarget, 7, 21272.
Kato Tatsuya, Lee Daiyoon, Wu Licun, Patel Priya, Young Ahn, Wada Hironobu, Hu Hsin-Pei, Ujiie Hideki, Kaji Mitsuhito, Kano Satoshi, Matsuge Shinichi, Domen Hiromitsu, Kaga Kichizo, Matsui Yoshiro, Kanno Hiromi, Hatanaka Yutaka, Hatanaka Kanako, Matsuno Yoshihiro, de Perrot Marc, Yasufuku Kazuhiro (2016), Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma, in
International Journal of Oncology, 448-456.
Meerang Mayura, B{é}}rard Karima, Friess Martina, Bitanihirwe Byron K.Y., Soltermann Alex, Vrugt Bart, Felley-Bosco Emanuela, Bueno Raphael, Richards William G., Seifert Burkhardt, Stahel Rolf, Weder Walter, Opitz Isabelle (2016), Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma, in
Molecular Oncology, 10(8), 1255-1265.
Kato Tatsuya, Lee Daiyoon, Wu Licun, Patel Priya, Young Ahn, Wada Hironobu, Hu Hsin-Pei, Ujiie Hideki, Kaji Mitsuhito, Kano Satoshi, Matsuge Shinichi, Domen Hiromitsu, Kanno Hiromi, Hatanaka Yutaka, Hatanaka Kanako, Kaga Kichizo, Matsui Yoshiro, Matsuno Yoshihiro, De Perrot Marc, Yasufuku Kazuhiro (2016), SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma, in
International Journal of Oncology, 2411-2420.
Blum Walter, Pecze László, Felley-Bosco Emanuela, Worthmüller-Rodriguez Janine, Wu Licun, Vrugt Bart, de Perrot Marc, Schwaller Beat (2015), Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line, in
In Vitro Cellular & Developmental Biology - Animal, 51(7), 714-721.
Barbone D., Follo C., Echeverry N., Gerbaudo V.H., Klabatsa A., Bueno R., Felley-Bosco E., Broaddus V.C. (2015), Autophagy correlates with the therapeutic responsiveness of Malignant pleural mesothelioma in 3D models, in
PLoS ONE, 10(8), 1180-1194.
Felley-Bosco Emanuela, Opitz Isabelle, Meerang Mayura (2015), Hedgehog Signaling in Malignant Pleural Mesothelioma., in
Genes, 6(3), 500-11.
Echeverry N, Ziltener G, Barbone D, Weder W, Stahel R A, Broaddus V C, Felley-Bosco E (2015), Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors., in
Cell death & disease, 6, e1757-1757.
Blum Walter, Pecze Laszlo, Felley-Bosco Emanuela, Schwaller Beat (2015), Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration, in
RESPIRATORY RESEARCH, 16, 1-16.
Rusch Andreas, Ziltener Gabriela, Nackaerts Kristiaan, Weder Walter, Stahel Rolf A, Felley-Bosco Emanuela (2015), Prevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases., in
Lung cancer (Amsterdam, Netherlands), 87(1), 77-9.
Pecze László, Blum Walter, Schwaller Beat (2015), Routes of Ca2+ shuttling during Ca2+ oscillations: Focus on the role of mitochondrial Ca2+ handling and cytosolic Ca2+ buffers, in
Journal of Biological Chemistry, 290(47), 28214-28230.
Stahel R A, Weder W, Felley-Bosco E, Petrausch U, Curioni-Fontecedro A, Schmitt-Opitz I, Peters S (2015), Searching for targets for the systemic therapy of mesothelioma., in
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 26(8), 1649-60.
Renganathan Arun, Kresoja-Rakic Jelena, Echeverry Nohemy, Ziltener Gabriela, Vrugt Bart, Opitz Isabelle, Stahel Rolf A, Felley-Bosco Emanuela (2014), GAS5 long non-coding RNA in malignant pleural mesothelioma., in
Molecular cancer, 13, 119-119.
Felley-Bosco Emanuela, Stahel Rolf (2014), Hippo/YAP pathway for targeted therapy., in
Translational lung cancer research, 3(2), 75-83.
Malignant pleural mesothelioma (MPM) is a cancer most often associated with the exposure to asbestos fibers. Although asbestos has been banned in most Western countries the incidence of MPM is still raising and asbestos-related diseases are still a major public health problem. In addition MPM incidence will also rise in countries, where asbestos has not been banned yet and where there are no stringent health protection policies. Of concern, mesothelioma could also be induced by man-made fibers (e.g. nanomaterials). Therefore, the investigation of molecular mechanisms of asbestos-induced carcinogenesis in a systemic approach should provide tools for molecular epidemiology in fiber-exposed individuals and will contribute to the understanding of inflammation-driven carcinogenesis. Our working hypothesis is that chronic inflammation/injury activates stem cell signalling and continuous stimulation of repair in an inflammatory setting leads to oncogenic events and escape from immune control. The work proposed herein involves three teams with a long-standing experience in mesothelioma research. Each team has a specific profile with respect to MPM research and the plan is to contribute to this project according to each team’s expertise. All teams will use the same experimental model, i.e. mice heterozygous for the tumor suppressor Nf2 (NF2+/-), which develop mesothelioma after exposure to asbestos, with the aim to characterize immune system and stem cell signalling activation in precancerous stages and during carcinogenesis. In addition we will functionally address the question, whether calretinin, which is currently considered as a positive marker for the identification of MPM, has a role in mesothelioma development. Besides the common work on the identical experimental animal model, each of the three groups will investigate specific molecular aspects in in vitro and in vivo models and results will be confirmed with observations obtained in clinical MPM samples. Our specific aims are to:•- acquire knowledge about the kinetics of the evolution of mesothelium environment and mesothelium tissue during asbestos-driven tumorigenesis•- evaluate the role of calretinin in MPM tumorigenesis including effects on immunotolerance and investigate protein molecular domains of calretinin and pathways possibly responsible for MPM formation•- explore the significance of variation in GAS5, a non-coding RNA, which is decreased upon asbestos-induced tumorigenesis Results obtained within this proposal are expected to provide clinically relevant information on mesothelioma tumorigenesis mechanisms, and the knowledge acquired could also be useful for future molecular epidemiology risk assessments on manmade materials.