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Clock synchronization: From brain to periphery or periphery to brain?

English title Clock synchronization: From brain to periphery or periphery to brain?
Applicant Albrecht Urs Emanuel
Number 146265
Funding scheme Project funding (Div. I-III)
Research institution Division de Biochimie Département de Biologie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Molecular Biology
Start/End 01.04.2013 - 31.03.2016
Approved amount 493'920.00
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All Disciplines (2)

Discipline
Molecular Biology
Physiology : other topics

Keywords (5)

metabolism; circadian clocks; food entrainment; Mammals; eating disorders

Lay Summary (German)

Lead
In Säugern koordiniert die innere Uhr viele Körperfunktionen wie zum Beispiel den Stoffwechsel und die Körpertemperatur. Zudem Steuert die innere Uhr auch das Verhalten wie zum Beispiel den Schlaf-Wach Zyklus und das Essverhalten. Obwohl die molekularen Komponenten der inneren Uhr bekannt sind ist noch weitgehend unerforscht wie die innere Uhr Körperfunktionen und das Verhalten des ganzen Organismus koordiniert.
Lay summary

Das übergeordnete Ziel dieses Projektes ist es zu verstehen wie die innere Uhr Hirnfunktionen mit den Aufgaben von anderen Geweben wie z.B. der Leber koordiniert. Dies versuchen wir anhand des Hungergefühls in Mäusen herauszufinden, denn sie können wie andere Tiere auch Fütterungszeit gut voraussagen und dies zeigen sie mit erhöhter Aktivität. Wir werden Mäuse mit einer defekten inneren Uhr studieren, die entweder in allen Körperzellen oder aber nur im Hirn und/oder nur in der Leber defekt ist. Diese Versuche werden Zeigen, ob das Essverhalten nur vom Hirn gesteuert ist oder aber ob die Leber einen wichtigen Beitrag zu diesem Verhalten leistet. Vergleiche der aktivierten Gene in diesen Mäusen werden auch aufzeigen, wie Uhrenproteine mit anderen Proteinen das Essverhalten steuern können. Dies kann zur Entwicklung neuer Strategien führen wie zum Beispiel Essstörungen behandelt werden könnten.

Direct link to Lay Summary Last update: 27.03.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Liver-derived ketone bodies are necessary for food anticipation
Albrecht Urs (2016), Liver-derived ketone bodies are necessary for food anticipation, in Nature Communications, 7, 10580.
Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment
Albrecht Urs (2015), Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment, in Chronobiol. Int., 32, 1075-1089.
Nucleotide excision repair efficiency in quiescent human fibroblasts is under control of the circadian clock
Albrecht Urs (2015), Nucleotide excision repair efficiency in quiescent human fibroblasts is under control of the circadian clock, in Nucleic Acids Research, 43, 2126-2137.
The mammalian circadian clock gene Per2 modulates cell death in response to oxidative stress
Albrecht Urs (2015), The mammalian circadian clock gene Per2 modulates cell death in response to oxidative stress, in Front. Neurol., 5, 289.
A specific role for the REV-ERBa controlled L-type voltage gated calcium channel Cav1.2 in resetting the circadian clock in the late night
Albrecht Urs (2014), A specific role for the REV-ERBa controlled L-type voltage gated calcium channel Cav1.2 in resetting the circadian clock in the late night, in J.Biol.Rhythms, 29, 288-298.
Rhythm and mood: Relationships between the circadian clock and mood-related behavior.
Schnell Anna, Albrecht Urs, Sandrelli Federica (2014), Rhythm and mood: Relationships between the circadian clock and mood-related behavior., in Behavioral Neuroscience, 128(3), 326-343.
The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis
Schnell Anna, Chappuis Sylvie, Schmutz Isabelle, Brai Emanuele, Ripperger Jürgen A., Schaad Olivier, Welzl Hans, Descombes Patrick, Alberi Lavinia, Albrecht Urs (2014), The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis, in PLoS ONE, 9(6), 99883-99883.
Circadian Clocks and Mood-Related Behaviors
Albrecht Urs (2013), Circadian Clocks and Mood-Related Behaviors, in Kramer Achim und Merrow Martha (ed.), Springer Science + Business Media, Berlin, 227-239.
Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range.
Albrecht Urs (2013), Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range., in J. R. Soc. Interface, 10, 20130221.
NONO couples the circadian clock to the cell cycle.
Albrecht Urs (2013), NONO couples the circadian clock to the cell cycle., in Proc. Natl. Acad. Sci. USA, 110, 1592-1599.
PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression.
Albrecht Urs (2013), PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression., in Molecular Metabolism, 292-305.
Role of the circadian clock gene Per2 in adaptation to cold temperature
Chappuis Sylvie, Ripperger Jürgen, Schnell Anna, Rando Gianpaolo, Jud Corinne, Wahli Walter, Albrecht Urs (2013), Role of the circadian clock gene Per2 in adaptation to cold temperature, in Molecular Metabolism, 2, 184-193.
Role of the circadian clock gene Per2 in adaptation to cold temperature.
Albrecht Urs (2013), Role of the circadian clock gene Per2 in adaptation to cold temperature., in Molecular Metabolism, 2, 184-193.
Synaptophysin is involved in resetting of the mammalian circadian clock
Aramendy Marie, Seibert Sascha, Treppmann Philipp, Richter Karin, Ahnert-Hilger Gudrun, Albrecht Urs (2013), Synaptophysin is involved in resetting of the mammalian circadian clock, in J Circad Rhythms, 11(1), 11-11.
Altered sleep homeostasis in Rev-erbα knockout mice
Albrecht Urs, Altered sleep homeostasis in Rev-erbα knockout mice, in Sleep.
REV-ERB-alpha regulates the orexigenic system to influence pleasurable feeding behaviors in mice
Albrecht Urs, REV-ERB-alpha regulates the orexigenic system to influence pleasurable feeding behaviors in mice, in Addiction Biology.

Collaboration

Group / person Country
Types of collaboration
Jorge Mendoza France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Franz Hofmann Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Dr. Jürgen Ripperger, Universität Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Paul Franken Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Michael Hastings Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Steven Brown Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Rodolfo Costa Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
LS2 Meeting 2016 Poster Phosphorylation of Per2 by CDK5 15.02.2016 Lausanne, Switzerland Brenna Andrea;
LS2 Meeting 2016 Talk given at a conference Regulation of Food anticipation 15.02.2016 Lausanne, Switzerland Chavan Rohit;
Cold Spring Harbor Conferences Asia Talk given at a conference Regulation of food anticipation 26.10.2015 Suzhou, China Albrecht Urs Emanuel;
8th Fribourg Obesity Rresearch Conference (FORC 2015) Talk given at a conference Clock genes as regulators of metabolic rhythms: interlinking locomotor activity, food-seeking behavior, and thermal regulation 10.09.2015 Fribourg, Switzerland Chavan Rohit; Brenna Andrea; Albrecht Urs Emanuel;
XIV European Biological Rhythms Society (EBRS) and IV World Congress of Chronobiology (WCC) Talk given at a conference Liver Period 2 is necessary to regulated food anticipation 02.08.2015 Manchester, Great Britain and Northern Ireland Chavan Rohit; Albrecht Urs Emanuel;
GNRH scientific meeting, Monash University Prato Center Talk given at a conference The Circadian Clock and Reproduction 27.04.2015 Prato, Italy Albrecht Urs Emanuel;
BENESCO Winter Conference Talk given at a conference Liver Period 2 gene regulates food anticipation 26.03.2015 Wengen, Switzerland Albrecht Urs Emanuel;
NeuroScience colloquium, NeuroCure Excellence Cluster, Charité, Universitätsmedizin Berlin Individual talk Food anticipation and the circadian clock 30.01.2015 Berlin, Germany Albrecht Urs Emanuel;
15th Zurich Sleep Medicine Symposium Talk given at a conference Methods in chronobiology 15.01.2015 Zürich, Switzerland Albrecht Urs Emanuel;
Brain Circuits for positive emotions, Centro Stefano Franscini Talk given at a conference Circadian clock in mood related behaviors 19.10.2014 Monte Verita, Ascona, Switzerland Albrecht Urs Emanuel;
Seminar Pharmacology Universität Zürich Individual talk Rev-erba and adult hippocampal neurogenesis 08.10.2014 Zürich, Switzerland Albrecht Urs Emanuel;
26th Annual Meeting of the Society for Light Treatment and Biological Rhythms Talk given at a conference The nuclear receptor REV-ERBa regulates Fabp7 an modulates adult hippocampal neurogenesis 27.06.2014 Wien, Austria Albrecht Urs Emanuel;
Meeting of the Society for Research on Biological Rhythms Talk given at a conference Circadian Physiological and Behavioral Methods in Rodents 14.06.2014 Big Sky, United States of America Albrecht Urs Emanuel;
Swiss Society for Sleep Research, Sleep Medicine and Chronobiology SSSSC Talk given at a conference Rev-erba and adult hippocampal neurogenesis 15.05.2014 Luzern, Switzerland Albrecht Urs Emanuel;
Seminar University of Padova Individual talk The circadian clock and cold temperature 16.04.2014 Padova, Italy Albrecht Urs Emanuel;
30th International Congress of Clinical Neurophysiology (ICCN) Talk given at a conference The circadian clock and its impact on physiology and behavior 20.03.2014 Berlin, Germany Albrecht Urs Emanuel;
BENESCO Winter Research Conference Talk given at a conference The clock component Rev-erba and adult hippocampal neurogenesis 13.03.2014 Adelboden, Switzerland Albrecht Urs Emanuel;
Seminar Biozentrum Basel Individual talk The circadian clock and its impact on physiology and behavior 18.02.2014 Basel, Switzerland Albrecht Urs Emanuel;
Neurotime Talk given at a conference The circadian clock and brain functions 02.02.2014 Amsterdam, Netherlands Albrecht Urs Emanuel;
Oberseminar Institute for Medical Psychology, LMU Munich Individual talk The circadian clock and its impact on physiology and behavior 14.10.2013 München, Germany Albrecht Urs Emanuel;
6th Student retreat of the Microbiology and Immunology Program ETH Zürich Talk given at a conference The circadian clock and its impact on physiology and behavior 13.09.2013 Locarno, Switzerland Albrecht Urs Emanuel;
XIII EBRS Congress Talk given at a conference Role of the clock gene Per2 in adaptation to cold temperature 18.08.2013 München, Germany Albrecht Urs Emanuel;
FENS/IBRO Neuroendocrinology Training School Talk given at a conference The Circadian Clock and its influence on Physiology and Behavior 26.07.2013 Prato, Italy Albrecht Urs Emanuel;
25th Annual Meeting of the Society for Light Treatment and Biological Rhythms Talk given at a conference The Circadian Clock and Mood Related Behaviors 21.06.2013 Genf, Switzerland Albrecht Urs Emanuel;
Neurex Meeting Talk given at a conference From central to peripheral clocks and back 03.06.2013 Strasbourg, France Albrecht Urs Emanuel;


Self-organised

Title Date Place
4th Swiss Chronobiology Meeting 03.09.2015 Fribourg, Switzerland
3rd Swiss Chronobiology Meeting 04.09.2014 Fribourg, Switzerland
2nd Swiss Chronobiology Meeting 05.09.2013 Fribourg, Switzerland

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Der Winterblues: Ein Mangel an Licht wellness & gesundheit Nr. 58 German-speaking Switzerland 2015
Talks/events/exhibitions 125 Jahr Feier der Universität Fribourg Western Switzerland Rhaeto-Romanic Switzerland 2014
Talks/events/exhibitions Cafés scientifiques Western Switzerland 2014
Talks/events/exhibitions Naturforschende Gesellschaft Basel German-speaking Switzerland 2014
Talks/events/exhibitions Riehener Diskussionsabend German-speaking Switzerland 2014
Talks/events/exhibitions Woche des Gehirns German-speaking Switzerland 2014
Talks/events/exhibitions TecDay at Collège Saint Michel Western Switzerland 2013

Associated projects

Number Title Start Funding scheme
166682 Adaptation of the circadian clock to changes in the environment 01.04.2016 Project funding (Div. I-III)
157752 Microchip-based flow cell sorting in biomedicine and material sciences 01.05.2015 R'EQUIP
141960 FGF21 is a link between reproduction and energy balance 01.12.2012 Sinergia
131086 Adaptation mechanisms of the circadian clock to light and temperature 01.04.2010 Project funding (Div. I-III)

Abstract

The physiology of an organism, including endocrine signaling, metabolism, temperature regulation, sleep and feeding, is organized in a temporal fashion coordinated by the circadian clock system. This ensures that all organs and body functions are optimally tuned to each other avoiding interference between processes such as anabolic and catabolic biochemical pathways. The proposed research focuses on the mechanisms underlying synchronization of behavioral pathways within the brain and between the brain and peripheral organs. It is based on the importance of the clock component PER2 in the synchronization of various behavioral and molecular processes, including anticipation of feeding time and coordination of metabolism.Lesion of the suprachiasmatic nuclei (SCN), the master regulator of the circadian system in the brain, leads to arrhythmic locomotor activity in mammals. This activity rhythm can be restored submitting these animals to a daily timed access to food. After a few days these animals can even anticipate feeding time, indicating that an SCN-independent food entrainable oscillator (FEO) exists. We aim to identify the anatomical substrate(s) of the FEO exploiting the fact that a mutation of Per2 abolishes FEO function. In a complementary approach we aim to identify genes whose transcription is affected by PER2. PER2 regulated genes expressed in the region(s) of the FEO will lead to identification of molecular pathways making up the FEO.
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