metabolism; circadian clocks; food entrainment; Mammals; eating disorders
Albrecht Urs (2016), Liver-derived ketone bodies are necessary for food anticipation, in Nature Communications
, 7, 10580.
Albrecht Urs (2015), Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment, in Chronobiol. Int.
, 32, 1075-1089.
Albrecht Urs (2015), Nucleotide excision repair efficiency in quiescent human fibroblasts is under control of the circadian clock, in Nucleic Acids Research
, 43, 2126-2137.
Albrecht Urs (2015), The mammalian circadian clock gene Per2 modulates cell death in response to oxidative stress, in Front. Neurol.
, 5, 289.
Albrecht Urs (2014), A specific role for the REV-ERBa controlled L-type voltage gated calcium channel Cav1.2 in resetting the circadian clock in the late night, in J.Biol.Rhythms
, 29, 288-298.
Schnell Anna, Albrecht Urs, Sandrelli Federica (2014), Rhythm and mood: Relationships between the circadian clock and mood-related behavior., in Behavioral Neuroscience
, 128(3), 326-343.
Schnell Anna, Chappuis Sylvie, Schmutz Isabelle, Brai Emanuele, Ripperger Jürgen A., Schaad Olivier, Welzl Hans, Descombes Patrick, Alberi Lavinia, Albrecht Urs (2014), The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis, in PLoS ONE
, 9(6), 99883-99883.
Albrecht Urs (2013), Circadian Clocks and Mood-Related Behaviors, in Kramer Achim und Merrow Martha (ed.), Springer Science + Business Media, Berlin, 227-239.
Albrecht Urs (2013), Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range., in J. R. Soc. Interface
, 10, 20130221.
Albrecht Urs (2013), NONO couples the circadian clock to the cell cycle., in Proc. Natl. Acad. Sci. USA
, 110, 1592-1599.
Albrecht Urs (2013), PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression., in Molecular Metabolism
Chappuis Sylvie, Ripperger Jürgen, Schnell Anna, Rando Gianpaolo, Jud Corinne, Wahli Walter, Albrecht Urs (2013), Role of the circadian clock gene Per2 in adaptation to cold temperature, in Molecular Metabolism
, 2, 184-193.
Albrecht Urs (2013), Role of the circadian clock gene Per2 in adaptation to cold temperature., in Molecular Metabolism
, 2, 184-193.
Aramendy Marie, Seibert Sascha, Treppmann Philipp, Richter Karin, Ahnert-Hilger Gudrun, Albrecht Urs (2013), Synaptophysin is involved in resetting of the mammalian circadian clock, in J Circad Rhythms
, 11(1), 11-11.
Albrecht Urs, Altered sleep homeostasis in Rev-erbα knockout mice, in Sleep
Albrecht Urs, REV-ERB-alpha regulates the orexigenic system to influence pleasurable feeding behaviors in mice, in Addiction Biology
The physiology of an organism, including endocrine signaling, metabolism, temperature regulation, sleep and feeding, is organized in a temporal fashion coordinated by the circadian clock system. This ensures that all organs and body functions are optimally tuned to each other avoiding interference between processes such as anabolic and catabolic biochemical pathways. The proposed research focuses on the mechanisms underlying synchronization of behavioral pathways within the brain and between the brain and peripheral organs. It is based on the importance of the clock component PER2 in the synchronization of various behavioral and molecular processes, including anticipation of feeding time and coordination of metabolism.Lesion of the suprachiasmatic nuclei (SCN), the master regulator of the circadian system in the brain, leads to arrhythmic locomotor activity in mammals. This activity rhythm can be restored submitting these animals to a daily timed access to food. After a few days these animals can even anticipate feeding time, indicating that an SCN-independent food entrainable oscillator (FEO) exists. We aim to identify the anatomical substrate(s) of the FEO exploiting the fact that a mutation of Per2 abolishes FEO function. In a complementary approach we aim to identify genes whose transcription is affected by PER2. PER2 regulated genes expressed in the region(s) of the FEO will lead to identification of molecular pathways making up the FEO.