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Evaluation of Vitamin D Status and Its Determinants in Switzerland and of Possibilities to Improve Vitamin D Status in the Swiss Population

English title Evaluation of Vitamin D Status and Its Determinants in Switzerland and of Possibilities to Improve Vitamin D Status in the Swiss Population
Applicant Rohrmann Sabine
Number 145194
Funding scheme NRP 69 Healthy Nutrition and Sustainable Food Production
Research institution Institut für Epidemiologie, Biostatistik und Prävention Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Dietetics
Start/End 01.11.2013 - 31.07.2018
Approved amount 397'559.00
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All Disciplines (4)

Discipline
Dietetics
Agricultural Engineering
Nutritional Research, Vitaminology
Methods of Epidemiology and Preventive Medicine

Keywords (4)

genetics; pregnancy; fermented dairy products; vitamin D

Lay Summary (German)

Lead
Vitamin D ist ein wichtiger Nährstoff für den Knochenaufbau und eine ungenügende Versortung spielt möglicherweise eine Rolle bei Herzkreislauferkrankungen und einigen Krebsarten. Diese chronischen Krankheiten zeigen sich erst im Erwachsenenalter, aber bereits die Nährstoffversorgung während der Schwangerschaft hat einen bedeutenden Einfluss auf ihre Entwicklung.
Lay summary

Hintergrund

Die Vitamin-D-Versorgung von Schwangeren in der Schweiz ist weitgehend unbekannt. Ebenso wenig bekannt ist, ob die Empfehlung an Schwangere, Vitamin D zu supplementieren, einen Einfluss auf die Vitamin-D-Versorgung hat und welchen Einfluss genetische Unterschiede in Vitamin-D-Stoffwechsel auf den Vitamin-D-Status haben.

Ziel

Erstes Ziel ist die Untersuchung von Vitamin-D-Blutspiegeln bei Schwangeren und ihren Babies. Da die Hautpigmentierung einen entscheidenden Einfluss auf den Vitamin-D-Blutspiegel hat, möchten wir die Versorgung von hell- und dunkelhäutigen Frauen/Babies miteinander vergleichen. Auch verschiedene Gene haben einen Einfluss auf den Blutspiegel von aktivem Vitamin D. Darüber hinaus gibt es sogenannte epigenetische Mechanismen, die die Aktivität von Genen steuern und auf diesem Wege ebenfalls den Vitamin-D-Spiegel beeinflussen. Beides ist derzeit noch wenig untersucht; wir möchten als zweites Ziel genetische und epigenetische Effekte auf den Vitamin-D-Stoffwechsel untersuchen und besonders schauen, ob sich dies zwischen Frauen und Babies verschiedener Hautfarbe unterscheidet.

Bedeutung

Unsere Studie ist die erste, die die Vitamin-D-Versorgung von Schwangeren und Neugeborenen in der Schweiz untersucht. Da wir die Vitamin-D-Versorgung am Anfang und am Ende der Schwangerschaft untersuchen, werden wir eine Aussage machen können, ob die derzeitigen Empfehlungen der Eidgenössische Ernährungskommission helfen, den Vitamin-D-Status von Schwangeren zu verbessern. Unser Projekt soll auch einen Beitrag zur Frage leisten, ob Frauen mit dunkler Hautfarbe und somit besonders gefährdet für einen Mangel, häufig Migrantinnen, besondere Empfehlungen zur Vitamin-D-Versorgung benötigen. Mit der Untersuchung von genetischen und epigenetischen Unterschieden im Vitamin-D-Stoffwechsel werden weitere möglicherweise stärker Vitamin-D-Mangel-gefährdete Personengruppen identifiziert.

Direct link to Lay Summary Last update: 21.08.2013

Lay Summary (English)

Lead
Vitamin D is an important nutrient for bone health, but sub-optimal levels of vitamin D may also increase the risk of cardiovascular disease and some types of cancer. These chronic diseases affect the health of adult/older individuals but nutrient status during pregnancy has an important effect on the development of these diseases later in life.
Lay summary

Background

Vitamin D status of pregnant women in Switzerland is unknown, and in addition, it is also unknown whether the current recommendation to supplement vitamin D intake during pregnancy improves vitamin D status of pregnant women. It is also not well examined whether and how strongly genetic differences in vitamin D metabolism affect vitamin D status of pregnant women and their newborns.

Aim

The first aim of our project is to examine circulating vitamin D concentration in pregnant women and their offspring. Since skin pigmentation is an important determinant of vitamin D levels, we will compare vitamin D status of women/babies with light and dark skin color. Also, a variety of gene affects circulating vitamin D levels and the concentration of active vitamin D. In addition to genetic differences there are also so-called epigenetic mechanisms that are responsible for the activity of genes, which alter vitamin D level by changing the activity of genes. Thus, the second aim of our study is to examine genetic and epigenetic effects on vitamin D metabolism and particularly whether this differs between women and babies of different skin color.

Significance

This study will be the first in Switzerland to determine vitamin D concentrations in pregnant women and neonates. By comparing the vitamin D status of a group of women at the beginning of pregnancy and at its end, we will be able to draw conclusions on the effectiveness of vitamin D supplementation recommendations for pregnant women. Currently, it is unknown whether the recommendation of 600 IU does indeed improve the women’s vitamin D status, especially in women with darker skin, who have a higher risk of being vitamin D deficient. By integrating genetic and epigenetic aspects, we will identify sub-groups of the population that might be predisposed to vitamin D deficiency.

Direct link to Lay Summary Last update: 21.08.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Prevalence and determinants of vitamin D deficiency in the third trimester of pregnancy: a multicentre study in Switzerland
Krieger Jean-Philippe, Cabaset Sophie, Canonica Claudia, Christoffel Ladina, Richard Aline, Schröder Therese, von Wattenwyl Begoña Lipp, Rohrmann Sabine, Lötscher Katharina Quack (2018), Prevalence and determinants of vitamin D deficiency in the third trimester of pregnancy: a multicentre study in Switzerland, in British Journal of Nutrition, 119(03), 299-309.
Prevalence of Vitamin D Deficiency and Its Associations with Skin Color in Pregnant Women in the First Trimester in a Sample from Switzerland
Richard Aline, Rohrmann Sabine, Quack Lötscher Katharina (2017), Prevalence of Vitamin D Deficiency and Its Associations with Skin Color in Pregnant Women in the First Trimester in a Sample from Switzerland, in Nutrients, 9(3), 260-260.

Collaboration

Group / person Country
Types of collaboration
University of Freiburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
DGEpi Jahrestagung Poster Prevalence and determinants of vitamin D deficiency in the third trimester of pregnancy: a mul*centric study in Switzerland 05.09.2017 Lübeck, Germany Krieger Jean-Philippe;
DGEpi Jahrestagung Poster Vitamin D status and its determinants in healthy pregnant women living in Switzerland in the first trimester of pregnancy 05.09.2017 Lübeck, Germany Cabaset Sophie;
SGGG conference Poster Vitamin D in mother and child – differences by skin type and region 28.06.2017 Lausanne, Switzerland Quack Lötscher Katharina Christine;
AICR Conference Talk given at a conference Serum vitamin D concentration in pregnant women of light and dark skin color in Zurich (Switzerland) 13.11.2016 Washington DC, United States of America Rohrmann Sabine;
SGGG conference Poster Vitamin D in early pregnancy: differences by skin color 22.06.2016 Interlaken, Switzerland Quack Lötscher Katharina Christine;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Fortbildung der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe Talk 22.06.2017 University Hospital Zurich, Switzerland Quack Lötscher Katharina Christine;


Self-organised

Title Date Place
Meeting of the Public Health Nutrition Group of Public Health Schweiz 05.09.2016 EBPI, University of Zurich, Switzerland

Abstract

The recommendations of the Swiss Federal Office of Public Health and of the D-A-CH reference values for vitamin D have recently been elevated substantially. Thus, a considerable percentage of the population living in Switzerland is effected by vitamin D deficiency, in particular during winter months, when endogenous vitamin D production due to sun exposure in insufficient. In our project, we aim at an integrating approach to examine on the one hand whether genetic and epigenetic variability in the population living in Switzerland might contribute to vitamin D status of a particularly vulnerable part of the population, and on the other hand we will investigate possibilities to increase vitamin D levels in foods frequently consumed in Switzerland.Firstly, we will determine vitamin D levels in pregnant women and their offspring (cord blood), which is a particularly vulnurable group of the population and for which no data on vitamin D levels are available in Switzerland. For this group, we will additionally examine whether women with a dark skin colour and their babies have an increased risk of being vitamin D deficient compared with women with a lighter skin colour. Secondly, we will make use of food preferences in Switzerland and explore whether vitamin D content of fermented dairy products can be enriched or fortified with vitamin D.
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