Projekt

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Cell Migration

Titel Englisch Cell Migration
Gesuchsteller/in Wolf Marlene
Nummer 137087
Förderungsinstrument ProDoc
Forschungseinrichtung Theodor Kocher Institut Medizinische Fakultät Universität Bern
Hochschule Universität Bern - BE
Hauptdisziplin Immunologie, Immunpathologie
Beginn/Ende 01.09.2011 - 31.10.2016
Bewilligter Betrag 149'678.00
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Alle Disziplinen (2)

Disziplin
Immunologie, Immunpathologie
Experimentelle Krebsforschung

Keywords (7)

cell migration; immune cell trafficking; inflammation; tumour metastasis; tumour invasion; inflammation; live cell imaging

Lay Summary (Englisch)

Lead
Lay summary

Cell migration is a fundamental process of life. Unicellular organisms such as amoeba have to migrate to reach food and to mate. In multicellular organisms cell migration of individual cells or coordinated multicellular migration is required for gastrulation, morphogenesis and organogenesis (e.g. angiogenesis). Furthermore, the entire homeostasis of multicellular organisms relies on processes of cell migration including the process of immunosurveillance. Finally, cell migration is a crucial process during inflammation and tissue repair and is an integral mechanism of many pathological processes such as chronic inflammatory diseases and tumor metastasis. Immune and tumor cell migration are therefore two topics of outmost biomedical significance. 

With the ProDoc “Cell migration” we bring together experts from both the immunology and the tumor cell biology communities to investigate mechanism involved in the regulation of cell migration and to establish a training program for highly qualified PhD and MD-PhD students in this field. The program combines the research focus and state-of the art equipment of the Theodor Kocher Institute at the University of Bern for stuying cell migration by means of live cell imaging technologies, the strong focus and international reputation of the Institute for Research in Biomedicine (IRB) in Bellinzona on mouse and human immunology and the competence of rese arch groups at the University of Fribourg on the recruitment of immune effector cells into tumours and tumour-host interactions. These complementary scientific expertises and the diverse research tools that are used in the different laboratories provide a unique framework for the training of young scientists. The PhD students in the ProDoc “Cell migration” are exposed to state-of-the art investigative methods such as live cell in vitro and in vivo imaging, transgenic mouse models and human in vitro models. They will acquire highly competitive scientific skills which will set the ground for a successful career.

Within the ProDoc “Cell migration” the PhD students are grouped in three research modules. Research Module I aims to study immune cell migration during immunosurveillance and inflammation, Research Module II focuses on cell migration in tumorigenesis and metastasis and Research Module III investigates the role of soluble factors in regulating cell migration. A central feature of the ProDoc “Cell migration” is collaborative and interdisciplinary research which requires mobility of the students. The PhD students perform specific parts of their thesis within the different participating laboratories and in this way will gain a broad theoretical and methodological know-how that could not be acquired in the individual laboratories and that will allow them to build up a scientific network. The program also includes advanced lectures, seminars and workshops in different aspects of cell migration, both theoretically and practically and the students have the opportunity to present their work at international meeting. The ProDoc “Cell migration” initiates a new research network among Swiss research groups in the field of cell migration in immunosurveillance, inflammation and cancer and this collaboration will certainly continue past the duration of the program and will contribute to persistent progress in cancer and inflammation research.
Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells.
Priebe Magdalena, Widmer Jérôme, Suhartha Löwa Nina, Abram Sarah-Luise, Mottas Inès, Woischnig Anne-Kathrin, Brunetto Priscilla S, Khanna Nina, Bourquin Carole, Fromm Katharina M (2016), Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells., in Nanomedicine : nanotechnology, biology, and medicine, 13(1), 11-22.
Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking
Cecchinato Valentina, D'Agostino Gianluca, Raeli Lorenzo, Uguccioni Mariagrazia (2016), Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking, in JOURNAL OF LEUKOCYTE BIOLOGY, 99(6), 851-855.
Light sheet fluorescence microscopy for in situ cell interaction analysis in mouse lymph nodes.
Abe Jun, Ozga Aleksandra J, Swoger Jim, Sharpe James, Ripoll Jorge, Stein Jens V (2016), Light sheet fluorescence microscopy for in situ cell interaction analysis in mouse lymph nodes., in Journal of immunological methods, 431, 1-10.
Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier.
Lazarevic Ivana, Engelhardt Britta (2016), Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier., in Fluids and barriers of the CNS, 13, 2-2.
pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.
Ozga Aleksandra J, Moalli Federica, Abe Jun, Swoger Jim, Sharpe James, Zehn Dietmar, Kreutzfeldt Mario, Merkler Doron, Ripoll Jorge, Stein Jens V (2016), pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion., in The Journal of experimental medicine, 213(12), 2811-2829.
Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro.
Rudolph Henriette, Klopstein Armelle, Gruber Isabelle, Blatti Claudia, Lyck Ruth, Engelhardt Britta (2016), Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro., in European journal of immunology, 46(9), 2187-203.
Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.
Tietz Silvia M, Zwahlen Marcel, Haghayegh Jahromi Neda, Baden Pascale, Lazarevic Ivana, Enzmann Gaby, Engelhardt Britta (2016), Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences., in European journal of immunology, 46(10), 2481-2483.
WNK1 kinase balances T cell adhesion versus migration in vivo.
Köchl Robert, Thelen Flavian, Vanes Lesley, Brazão Tiago F, Fountain Kathryn, Xie Jian, Huang Chou-Long, Lyck Ruth, Stein Jens V, Tybulewicz Victor L J (2016), WNK1 kinase balances T cell adhesion versus migration in vivo., in Nature immunology, 17(9), 1075-83.
In vivo TCR signaling in CD4+ T cells imprints a cell-intrinsic, transient low-motility pattern independent of chemokine receptor expression levels, or microtubular network, integrin, and protein kinase C activity
Ackerknecht Markus, Hauser Mark A., Legler Daniel F., Stein Jens V. (2015), In vivo TCR signaling in CD4+ T cells imprints a cell-intrinsic, transient low-motility pattern independent of chemokine receptor expression levels, or microtubular network, integrin, and protein kinase C activity, in Frontiers in Immunology, 6(JUN), 297.
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.
Tang Fengyuan, Gill Jason, Ficht Xenia, Barthlott Thomas, Cornils Hauke, Schmitz-Rohmer Debora, Hynx Debby, Zhou Dawang, Zhang Lei, Xue Gongda, Grzmil Michal, Yang Zhongzhou, Hergovich Alexander, Hollaender Georg A, Stein Jens V, Hemmings Brian A, Matthias Patrick (2015), The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility., in Science signaling, 8(397), 100-100.
TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection
Hotz Christian, Roetzer Laurin C., Huber Thomas, Sailer Andreas, Oberson Anne, Treinies Marina, Heidegger Simon, Herbst Tina, Endres Stefan, Bourquin Carole (2015), TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection, in JOURNAL OF IMMUNOLOGY, 195(9), 4387-4395.
Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier
Abadier Michael, Abadier Michael, Haghayegh Jahromi Neda, Haghayegh Jahromi Neda, Cardoso Alves Ludmila, Boscacci Rémy, Vestweber Dietmar, Barnum Scott, Deutsch Urban, Engelhardt Britta, Lyck Ruth (2014), Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier, in European Journal of Immunology, 45(4), 1043-1058.
PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.
Sathiyanadan Karthik, Coisne Caroline, Enzmann Gaby, Deutsch Urban, Engelhardt Britta (2014), PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE., in European journal of immunology, 44(8), 2287-94.
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.
Moretti Federico A, Moser Markus, Lyck Ruth, Abadier Michael, Ruppert Raphael, Engelhardt Britta, Fässler Reinhard (2013), Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells., in Proceedings of the National Academy of Sciences of the United States of America, 110(42), 17005-10.
Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions.
Coelho Fernanda M, Natale Daniela, Soriano Silvia F, Hons Miroslav, Swoger Jim, Mayer Jürgen, Danuser Renzo, Scandella Elke, Pieczyk Markus, Zerwes Hans-Günter, Junt Tobias, Sailer Andreas W, Ludewig Burkhard, Sharpe James, Figge Marc Thilo, Stein Jens V (2013), Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions., in Blood, 121(20), 4101-9.
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
Yan Yiqing, Jiang Wei, Spinetti Thibaud, Tardivel Aubry, Castillo Rosa, Bourquin Carole, Guarda Greta, Tian Zhigang, Tschopp Jurg, Zhou Rongbin (2013), Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation., in Immunity, 38(6), 1154-63.
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses
Marczynska Joanna, Ozga Aleksandra, Wlodarczyk Agnieszka, Majchrzak-Gorecka Monika, Kulig Paulina, Banas Magdalena, Michalczyk-Wetula Dominika, Majewski Pawel, Hutloff Andreas, Hutloff Andreas, Schwarz Jeanette, Chalaris Athena, Scheller Jürgen, Scheller Jürgen, Rose-John Stefan, Cichy Joanna (2013), The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses, in Journal of Immunology, 193(6), 2753-2763.
Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation.
Nitschké Maximilian, Aebischer David, Abadier Michael, Haener Simone, Lucic Matije, Vigl Benjamin, Luche Hervé, Fehling Hans Jörg, Biehlmaier Oliver, Lyck Ruth, Halin Cornelia (2012), Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation., in Blood, 120(11), 2249-58.
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses
Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan XF, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y (2012), DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses, in BLOOD, 119(19), 4451-4461.
Quantitative measurements in 3-dimensional datasets of mouse lymph nodes resolve organ-wide functional dependencies.
Mayer Jürgen, Swoger Jim, Ozga Aleksandra J, Stein Jens V, Sharpe James (2012), Quantitative measurements in 3-dimensional datasets of mouse lymph nodes resolve organ-wide functional dependencies., in Computational and mathematical methods in medicine, 2012, 128431-128431.
T-cell trafficking in the central nervous system
Sallusto F, Impellizzieri D, Basso C, Laroni A, Uccelli A, Lanzavecchia A, Engelhardt B (2012), T-cell trafficking in the central nervous system, in IMMUNOLOGICAL REVIEWS, 248, 216-227.
ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier
Lyck R., Abadier M., Wyss C.B., Sallusto F., Engelhardt B., ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier, in J Cereb Blood Flow Metab.
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.
Cecchinato V, Uguccioni M, D'Agostino G, Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization., in The Journal of Immunology, 1600568.

Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
Roméo Cecchelli, Lens Frankreich (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Marco Bianchi, Milan Italien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Elisabetta Dejana, Milano Italien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Yoshinori Fukui, Kyushu University, Fukuoka Japan (Asien)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Costantino Pitzalis, William Harvery Institute, London Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Scott Barnum, Birmingham Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Mario Mellado, CSIC, Madrid Spanien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Fengyuan Tang, Universität Basel Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
James Sharpe, CRG Barcelona Spanien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Richard Ransohoff, Cleveland Vereinigte Staaten von Amerika (Nordamerika)
- Publikation
Oliver Fackler, Heidelberg Deutschland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Victor Tybulewicz, NIMR, London Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Rick Maizels, Edinburgh Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Jonathan Sleeman, University of Heidelberg Deutschland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Alberto Mantovani, Milan Italien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Antonio Manzo, Pavia Italien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Dietmar Vestweber, Münster Deutschland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Edward Neuwelt, Portland Vereinigte Staaten von Amerika (Nordamerika)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Universität Fribourg Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Forschungsinfrastrukturen
Institute for Research in Biomedicine, Bellinzona Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
Maximilian Schnurr, Universität München Deutschland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Reinhard Fässler, München Deutschland (Europa)
- Publikation
Werner Help, University of Lausanne Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Vincenzo Bronte, Venetian Institute of Molecular Medicine, Padua Italien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Liblau and Jean-Charles Guery, Toulouse Frankreich (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Michael Sixt, Institute of Science and Technology, Wien Österreich (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Pedro Romero, University of Lausanne Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Andreas Bikfalvi, University of Bordeaux and INSERM Frankreich (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Burkhard Ludewig, Kantonsspital St. Gallen Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Brian Hemmings, Friedrich Miescher Institute, Basel Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation

Wissenschaftliche Veranstaltungen



Selber organisiert

Titel Datum Ort
4th Prodoc Cell Migration retreat 27.10.2016 Gunten, Schweiz
Hot topics in Immunology 12.04.2016 Fribourg, Schweiz
Hot Topics in Cancer Research 23.02.2016 Fribourg, Schweiz
Cytomeet 26.01.2016 Bern, Schweiz
Career Day in Life Science 22.01.2016 Fribourg, Schweiz
Cancer and Immunity: Ask the Expert 13.01.2016 Fribourg, Schweiz
4th Prodoc Cell Migration Workshop 17.11.2015 Gurten-Bern, Schweiz
Science and Ethics Workshop 09.09.2015 Fribourg, Schweiz
Workshop: Presenting with confidence 09.06.2015 Bern, Schweiz
Workshop: Applied Statistics 12.05.2015 Bern, Schweiz
Cancer and Immunity, Lecture and Workshop 04.03.2015 Fribourg, Schweiz
3rd ProDoc Cell Migration Retreat 11.02.2015 Weggis, Schweiz
Career Opportunities Workshops 2015 04.02.2015 Fribourg, Schweiz
25th Cytomeet 27.01.2015 Bern, Schweiz
Career Opportunities Workshops 2014 26.09.2014 Fribourg, Schweiz
Cancer and Immunity: Ask the expert 24.06.2014 Universität Fribourg, Schweiz
3rd ProDoc Cell Migration Workshop 10.06.2014 Bellinzona, Schweiz
Cytomeet, Universität Bern 14.01.2014 Bern, Schweiz
Symposium: Light Sheet Microscopy: 3D Insights Into Solid Organs 29.11.2013 Bern, Schweiz
MICROSCOPY APPLICATIONS FOR IMMUNOLOGICAL RESEARCH 13.11.2013 Bellinzona, Schweiz
2nd ProDoc Cell MIgration Retreat 07.11.2013 Weggis, Schweiz
Symposium – Transgenic Mouse Technologies 03.10.2013 Universität Bern, Schweiz
2nd ProDoc Cell Migration Workshop 02.07.2013 Universität Fribourg, Schweiz
1st ProDoc Cell Migration Retreat 27.11.2012 Schloss Münchenwiler, Schweiz
Good scientific practice 20.04.2012 Theodor Kocher Institut, Universität Bern, Schweiz
1st ProDoc Cell Migration Workshop 19.04.2012 Theodor Kocher Institut, Universität Bern, Schweiz
Multicolor Flow Cytometry 29.02.2012 Institute for Research in Biomedicine, Bellinzona, Schweiz

Kommunikation mit der Öffentlichkeit

Kommunikation Titel Medien Ort Jahr
Referate/Veranstaltungen/Ausstellungen Lange Nacht der Karriere Deutschschweiz 2015
Referate/Veranstaltungen/Ausstellungen 125 Jahre - Universität Fribourg Westschweiz Deutschschweiz 2014
Referate/Veranstaltungen/Ausstellungen Nacht der Forschung Deutschschweiz 2014
Neue Medien (Web, Blogs, Podcasts, NewsFeed, usw.) CellMigration Web Deutschschweiz 2012
Medienarbeit: Printmedien, Online-Medien Neues Doktoratsprogramm erforscht, wie Zellen wandern Universität Bern, Medieninformation Deutschschweiz 2011

Verbundene Projekte

Nummer Titel Start Förderungsinstrument
156372 RLR/TLR combination therapy: Mechanisms of T-cell recruitment into gastric tumors 01.06.2015 Projektförderung (Abt. I-III)
141773 ProDoc Cell Migration Research Module 3: Soluble factors in Cell Migration 01.10.2012 ProDoc
145038 Acquisition of a 2-Photon microscope for intravital analysis 01.12.2012 R'EQUIP
141773 ProDoc Cell Migration Research Module 3: Soluble factors in Cell Migration 01.10.2012 ProDoc

Abstract

The ProDoc Cell Migration is an initiative of the Theodor Kocher Institute (TKI) at the University of Bern (UNIBE), the Institute for Research in Biomedicine (IRB) in Bellinzona and the Chairs of Pathology and Pharmacology of the Faculty of Science at the University of Fribourg (UNIFR). Combining the research focus of the TKI on studying immune cell migration during immunosurveillance and inflammation by means of live cell imaging with the strong background on mouse and human immunology of the IRB, successful research collaborations between the laboratories of Britta Engelhardt and Jens V. Stein (TKI) and Federica Sallusto (IRB) have already been pursued. The recent recruitment of Curzio Rüegg and Carole Bourquin to UNIFR, together with the expertise of Mariagrazia Uguccioni (IRB) on expression of chemokines in tumor microenvironments regulating infiltration of immune cells and positioning of malignant cells, and of Urban Deutsch on the role of the Angiopoietin/Tie-2 in vascular biology and cancer, broadens our expertise to tumor cell biology and thus provides a profound basis for proposing the comprehensive ProDoc Cell Migration. Our complementary scientific expertises, the combination of in vivo mouse models and in vitro human models and the variety of technical platforms provide a unique framework for establishing an internationally visible training program for highly qualified PhD and MD/PhD students in the field of cell migration, the excellence of which could not be achieved at this level in the individual laboratories as such. Although the official language of the ProDoc will be English, the location of the participating institutions promotes the exposure of ProDoc students to the rich cultural diversity within Switzerland and will favor the acquisition of new languages (German, Italian and French) and thus complement the education of the students in view of future postdoctoral training and also support mobility. Within the ProDoc Cell Migration students will be grouped in two Research Modules, namely Research Module I: Immune cell migration during immunosurveillance and inflammation and Research Module II: Cell migration in tumorigenesis and metastasis, respectively. They will perform collaborative high quality research projects covering highly relevant aspects of cell migration. The six students, whose funding is requested in this application will perform specific parts of their PhD thesis within the different participating laboratories and will therefore provide the continuous and direct link within the ProDoc. Conceptually, the ProDoc Cell Migration is designed to convey to participating students in depth knowledge of the molecular events that control cell migration in both, mouse and human systems, and to confront them with a large armamentarium of state-of-the art technologies to study the questions at hand. The accompanying Training Module will be organized by Marlene Wolf, the coordinator of the interfaculty Graduate School for Cellular and Biological Sciences (GCB, www.gcb.unibe.ch) at UNIBE with 250 students enrolled currently. This module composed of lectures, practical classes, journal clubs, webportal-based training modules and meetings on the specific topics, is designed to guarantee the continuous interaction of the ProDoc students and to challenge them to become critical young researchers with professional communication skills and a strong desire for excellence as their future basis to promote their own ideas in research. In addition to the five students applied for here, eight students funded by other sources, including two national and international collaborative projects, will join the training module and benefit from all training activities and from the mobility and interactions offered within the ProDoc Cell Migration. Coordination of all research and training activities within the proposed ProDoc Cell Migration will be the obligation of the ProDoc steering committee B. Engelhardt (TKI), F. Sallusto (IRB), C. Rüegg (UNIFR) and M. Wolf (TKI), representing the institutions involved. Administration of the ProDoc Cell Migration will rely on the well established GCB at UNIBE, which will formally evaluate and approve applicants selected by the ProDoc steering committee. ProDoc students from TKI and IRB will be formally enrolled in this program, further strengthening the already established collaboration in postgraduate education between the two institutions. A strong teaching collaboration between UNIBE and UNIFR (BEFRI) is already in place in the context of the Master in Biomedical Sciences (BMS), a Graduate Program in Developmental Neurobiology and the recently planned Master Program in Bioinformatics, where the curriculum is shared between the universities. The establishment of the ProDoc Cell Migration would allow an extension of the BEFRI collaboration at the graduate level in the life sciences and should be instrumental in initiating a Graduate School in life sciences at UNIFR and enforcing the coordination of graduate studies between these universities.
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