Project

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Schweizer IBD Kohorten Studie

English title Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS)
Applicant Rogler Gerhard
Number 134274
Funding scheme Cohort Studies Large
Research institution Klinik für Gastroenterologie und Hepatologie Departement Innere Medizin Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Internal Medicine
Start/End 01.04.2011 - 31.03.2014
Approved amount 4'690'910.00
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All Disciplines (2)

Discipline
Internal Medicine
Group Medicine

Keywords (8)

Chronisch entzündliche Darmerkrankungen; Inflammatory Bowel Disease; Epidemiology; Pathophysiology; Crohn's disease; Ulcerative colitis; Appropriateness of care; Cohort study

Lay Summary (English)

Lead
Lay summary
Progress accumulated in the understanding of the genetic and immune pathogenesis of IBD, as well as the advent of modern immuno-modulating and biological therapies, have induced profound changes in the management - and possibly in the outcome - of IBD patients. However, there are major gaps in the knowledge needed for clinical decision making, including long-term drug safety of biological therapies, their interactions with older therapies, the relative benefits of the various possible treatment strategies, the chemo-prevention of colon cancer as well as the influence of current treatment options on patient physical, mental and psychosocial long-term state of health. Likewise, information available for global aspects of health care management of these patients is mostly derived from patient populations exposed to treatment strategies that are no longer the standard of care, and the impact of the novel treatment approaches is not established.

Based on the development of a population-based cohort in the State of Vaud (cohorte vaudoise), on pre-established criteria for appropriateness of care (EPACT), and taking advantage on the existence of a national network of IBD-oriented laboratories, clinical centres, private practice specialists and social and psychosocial medicine divisions in the country, the development of a prospective, countrywide cohort is proposed. The clinical and socio-economical data as well as the biological samples to be collected in this cohort aim in particular to analyse appropriateness of care, relations between therapy and patient outcome, impact of disease and therapy on mental health and other psychosocial factors, and economical aspects of patient care, including cost-effectiveness of novel therapeutical approaches as well as prospective evaluation of indirect costs (sick leave, unemployment, disability allowance etc). As IBD is a typical model of chronic relapsing inflammatory condition, at least some of the information obtained through this cohort may apply to other conditions like chronic rheumatologic diseases or dermatological conditions.

While some aspects of this project are country-specific, the proposed cohort has links to international epidemiological efforts in the field, including the European IBD population-based inception cohort (EC-IBD) and a Marie Curie educational grant in IBD-related epidemiology submitted by the European Crohn’s and Colitis Organization (ECCO), which already supported the development of the EPACT criteria.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Name Institute

Associated projects

Number Title Start Funding scheme
172870 The role of pH sensing G-protein coupled receptors for intestinal inflammation and fibrosis 01.05.2017 Project funding (Div. I-III)
138392 Pathophysiology of intestinal intraepithelial lymphocytes: Functional heterogeneity and plasticity of CD8aa TCRab T cells 01.11.2011 Project funding (Div. I-III)
138291 Dietary microparticles and their impact on Inflammatory Bowel Disease pathogenesis - Large Nested Project within the SWISS IBD Cohort Study 01.01.2012 Project funding (special)
146204 The role for Protein Tyrosine Phosphatase Non-receptor Type 2 in regulating the differentiation of CD4+, naive T-cells during chronic intestinal inflammation 01.04.2013 Project funding (special)
138498 Appropriateness of care in inflammatory bowel disease 01.03.2012 Project funding (special)
153380 The G-protein coupled pH receptor TDAG8 modulates intestinal inflammation 01.04.2014 Project funding (special)
108792 Swiss inflammatory bowel disease cohort study (SIBDCS) 01.04.2006 Cohort Studies Large
145006 Apparatus for Colonoscopy and Endoscopic Manipulations in Mice 01.09.2013 R'EQUIP
170109 Dietary nanoparticles and their impact on Inflammatory Bowel Disease pathogenesis - Large Nested Project within the SWISS IBD Cohort Study 01.10.2016 Project funding (special)
148422 Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) 01.04.2014 Cohort Studies Large

Abstract

Taking advantage on the existence of a national network of clinical centers, private practice spe-cialists, IBD-oriented laboratories, psychosocial medicine divisions and epidemiologists, a pro-spective, national cohort, the Swiss IBD Cohort (SIBDC), was successfully launched and is firmly established now. All major goals of the first grant application have been achieved. The hypotheses were finalized; variables selected and specific questionnaires were developed, tested, refined and implemented. A detailed project management plan, an operation manual and a data dictionary were prepared to guide cohort logistics and procedures. The study database was established by the Institute of Social and Preventive Medicine Lausanne. The data center is supervised by Prof. Dr. John Paul Vader and Dr. Valerie Pittet. The follow-up of patients is excellent and above 80% of initially recruited. More than 2600 patients were enrolled in the cohort by end of 2012, totalling > 8000 person-years of follow-up. The SIBDC biobank has collected almost 6000 specimens and supported more than 30 individual subprojects. The appropriateness of care project has evaluated the quality of care for IBD patients in Switzerland and has organized several European panel meeting. Main investigators of this core project are Prof. Dr. Pierre Michetti and Dr. Florian Fröhlich. The “mental health” core project has published a number of important studies on the interaction of psychological and physiological factors influencing the disease course in IBD patients. The mental health project is co-supervised by Prof. Roland von Kaenel and PD Dr. Stefan Begre. More than 30 nested projects have been supported by the SIBDC. Their results led to additional competitive funding and publications. International collaborations with genetic consortia (European and US) and epidemiological multinational cohorts have led to publications in Nature Genetics and other very visible journals. Based on these achievements, the current aims of the study are: 1) to maintain the basic infrastructure (e.g., datacentre, biobank, recruitment and follow-up activities); 2) to increase the valorisation of the SIBDC data and samples through hori-zontal and vertical networking and through novel collaborations with qualified research groups inside and outside Switzerland; 3) to translate research results into medical practice (knowledge transfer, educational activities and guidelines development and dissemination); 4) to strengthen the input from the patients into the scientific and medical agendas of SIBDC (in collaboration with “Schweizer Morbus Crohn und Colitis ulcerosa Vereinigung”, SMCCV); 5) to implement structures for network-based and investigator-initiated clinical research; 6) to publish the results of the 5-year follow-up epidemiological data and core project results; 7) to integrate the “eosinophil gastroenteritis group” and their epidemiological data as a further subgroup of IBD and to collaborate closely with the IBDnet, an established group of IBD practitioners, especially in the field of educational activities.
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