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Replication of paramyxoviruses

Applicant Kolakofsky Daniel
Number 67280
Funding scheme Project funding (Div. I-III)
Research institution Dépt Microbiologie et Médecine Moléculaire Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Molecular Biology
Start/End 01.04.2002 - 31.03.2008
Approved amount 1'258'333.00
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Keywords (5)

NEGATIVE-STRAND RNA VIRUS; PARAMYXOVIRUS; RNA SYNTHESIS; INTERFERON; APOPTOSIS

Lay Summary (English)

Lead
Lay summary
Sendai virus is studied as model for other paramyxoviruses that cause serious disease in humans, like measles, and mumps, and respiratory syncytial virus. During this grant period, we have studies how the host cell responds to infection with this model paramyxovirus, by activating the genes for interferon beta and other cytokines involved in inflammation. We have also studied how the virus tries to counteract this innate immune response of the host via expression of the longer forms of the viral C proteins. Finally, we have studies how this model paramyxovirus expresses the viral genetic program, by studying how the viral polymerase finds the sites on the viral genome at which mRNA synthesis begins.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
116114 Interactions of Paramyxoviruses and host cells 01.04.2007 Project funding (Div. I-III)
49438 Replication of paramyxoviruses 01.04.1997 Project funding (Div. I-III)

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