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Ca2+ signalling in cardiac muscle: the role of elementary events and the Na-Ca exchange

Applicant Niggli Ernst
Number 50564
Funding scheme Project funding (Div. I-III)
Research institution Institut für Physiologie Medizinische Fakultät Universität Bern
Institution of higher education University of Berne - BE
Main discipline Cardiovascular Research
Start/End 01.10.1997 - 30.09.2000
Approved amount 450'000.00
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Lay Summary (English)

Lay summary
In the present research project Ca2+ signaling is investigated in cardiac muscle cells on the cellular and subcellular level using a combination of biophysical and molecular biology methods (laser-scanning confocal microscopy, UV-laser flash photolysis of caged compounds, two-photon excitation of fluorescent indicators and caged compounds, the patch-clamp technique, expression of cloned genes and antisense inhibition of expression). In particular, properties of the recently discovered elementary events of cellular Ca2+ signaling, the Ca2+ sparks, are examined. In addition, the role of the Na-Ca exchanger and several ion channels is analyzed in the process of Ca2+ signaling and cardiac contraction. In heart muscle cells the L-type Ca channels (DHP receptors), the SR Ca2+ release channels (Ryanodine receptors) and the Na-Ca exchangers are important regulators of the Ca2+-homeostasis and thus determine the force produced during each heart-beat.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
61344 Efficiency of calcium signaling and excitation-contraction coupling in the heart: modulation by calcium load and beta-adre- nergic stimulation 01.10.2000 Project funding (Div. I-III)
37417 Regulatory mechanisms in cardiac contraction and relaxation: cellular and molecular function of the Na-Ca exchange 01.10.1993 Project funding (Div. I-III)