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Building the path to resilience after preterm birth: cortical development and network based interventions in longitudinal cohorts

English title Building the path to resilience after preterm birth: cortical development and network based interventions in longitudinal cohorts
Applicant Hüppi Petra
Number 182832
Funding scheme Project funding (Div. I-III)
Research institution Service de Développement et Croissance Département de Pédiatrie Hôpital des Enfants - HUG
Institution of higher education University of Geneva - GE
Main discipline Paediatrics
Start/End 01.02.2019 - 31.01.2022
Approved amount 899'922.00
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Keywords (6)

Resilience; Imaging; Salience; Prematurity; Mindfulness; Brain

Lay Summary (French)

Lead
Comment soutenir et soigner le cerveau des prématurés
Lay summary
Le projet repose sur le concept selon lequel l'activité conditionne le développement cérébral précoce et propose de nouvelles interventions basées sur l'activité pour soutenir le développement cérébral des nourrissons et des enfants nés prématurément.
Dans la période néonatale, une exposition contrôlée à la musique instrumentale ou vocale est proposée aux prématurés et les effets de cette intervention en aveugle contrôlé sur le développement cérébral structurel et fonctionnel sont évalués à l'aide de techniques avancées de neuro-imagerie (IRM, EEG fUS) et de résultats à long terme pour le développement cognitif et le langage.
Pour les enfants et les adolescents nés prématurément, les réseaux cérébraux dont on sait qu’ils sont altérés sont le réseau de saillance qui permettait d’identifier la pertinence d’un stimulus endogène ou exogène et d’adapter le comportement consécutif. Pour former spécifiquement ces réseaux, des interventions telles que la formation à la pleine conscience sont proposées et testées si elles sont efficaces pour modifier les réseaux altérés dans une étude contrôlée longitudinale utilisant la neuroimagerie avancée et des tests cognitifs et comportementaux. Le projet global fournira de nouvelles données sur la manière d’induire la résilience du cerveau dans les conditions défavorables précoces de la vie, telles que les naissances prématurées.

Direct link to Lay Summary Last update: 08.01.2019

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Associated projects

Number Title Start Funding scheme
163084 Building the path to resilience in preterm infants: a neuroimaging investigation of the impact of multisensory and neurocognitive interventions 01.02.2016 Project funding (special)
102127 Hypoxia-Ischemia in the developing brain. Correlations between electrophysiological activity, biomarkers of brain injury, advanced Magnetic Resonance Imaging and neurodevelopmental outcome 01.01.2004 Project funding (Div. I-III)
113632 Development of Executive Functions in children born prematurely in relation to neurostructural brain development 01.04.2007 Project funding (Div. I-III)
135817 Development of Emotion and Cognition in Preterm Born Cohorts: Neurostructural and Neurofunctional Correlates from Birth to Early Adolescence 01.10.2011 Project funding (special)
124101 From cortex to classroom: enhancing brain development for premature infants 01.10.2009 SPUM

Abstract

Early life events such as premature birth are important modulators of brain development with neurological and neuropsychiatric consequences through childhood and into adult life. 7.6% of all birth in Switzerland occur prematurely, 1% are born very premature and 35% of them develop neurodevelopmental impairments. Since 2000 (SNF3200-056927-102127-113632, 32473B-135817,33CM30-124101-140334,324830-163084), we have established longitudinal cohorts of preterm infants born in the Lemanic region, that are followed-up both with newly developed neuroimaging tools combined with motor, cognitive and behavioral evaluations.One of the major concerns today for population of growing up preterm infants is the very high rate of mental disorders in adolescence, among them high rates of neuropsychiatric disorders. This current grant addresses the important question on the mental outcome of our cohort in adolescence age and on how to intervene in order to improve mental health of premature infants. From the ongoing grant period in which we for the first time introduced a sensory intervention (instrumental music) in the newborn period and cognitive interventions (VAV and mindfulness based intervention MBI) in childhood, we know that music importantly improved functional connectivity of one of the recently described major brain network in adults affected by prematurity, the salience network. The current grant proposal elaborates on how to induce resilience through more predictable stimuli and tests the role of multisensory (music and vocal music), behaviorally appropriate stimuli in the newborn period to influence the cortical maturation and functional network development in the newborn and in childhood. Given that our longitudinal cohort now enters adolescence mental health outcome and its underlying brain structural and functional basis is a main aim of the current proposal, in addition to that given the prior intervention groups (socio-emotional training and Mindfulness based intervention) we will be able to test their longterm effect on mental health and brain network development such as salience connectivity.
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