epidemiology; cardiac complications; myocardial injury; prognosis; perioperative care; non-cardiac surgery; risk prediction
Lurati Buse Giovanna A.L., Puelacher Christian, Menosi Gualandro Danielle, Genini Alessandro S., Hidvegi Reka, Bolliger Daniel, Arslani Ketina, Steiner Luzius A., Kindler Christoph, Mueller Christian, Gueckel Johanna, Strebel Ivo, Liffert Marcel, Wolff Thomas, Mujagic Edin, Guerke Lorenz, Hammerer-Lercher Angelika, Rentsch Katharina, Boeddinghaus Jasper, Nestelberger Thomas, Wildi Karin, Zimmermann Tobias, Prepoudis Alexandra, Lampart Andreas (2020), Association between self-reported functional capacity and major adverse cardiac events in patients at elevated risk undergoing noncardiac surgery: a prospective diagnostic cohort study, in British Journal of Anaesthesia
Hidvegi Reka, Puelacher Christian, Gualandro Danielle M., Lampart Andreas, Lurati Buse Giovanna, Hammerer-Lerchner Angelika, Walter Joan, Liffert Marcel, Bolliger Daniel, Steiner Luzius, Kindler Christoph, Espinola Jaqueline, Strebel Ivo, Gueckel Johanna, Marbot Stella, Arslani Ketina, Boeddinghaus Jasper, Nestelberger Thomas, Zimmermann Tobias, Freese Michael, Guerke Lorenz, Mujagic Edin, Rikli Daniel, Buser Andreas, Mueller Christian (2020), Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery, in Clinical Research in Cardiology
, 109(9), 1140-1147.
du Fay de Lavallaz Jeanne, Puelacher Christian, Lurati Buse Giovanna, Bolliger Daniel, Germanier Dominic, Hidvegi Reka, Walter Joan Elias, Twerenbold Raphael, Strebel Ivo, Badertscher Patrick, Sazgary Lorraine, Lampart Andreas, Espinola Jaqueline, Kindler Christoph, Hammerer-Lercher Angelika, Thambipillai Saranya, Guerke Lorenz, Rentsch Katharina, Buser Andreas, Gualandro Danielle, Jakob Marcel, Mueller Christian (2019), Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome, in Heart
, 105(11), 826-833.
Gualandro Danielle M, Puelacher Christian, LuratiBuse Giovanna, Lampart Andreas, Strunz Celia, Cardozo Francisco A, Yu Pai C, Jaffe Allan S, Barac Sanela, Bock Lukas, Badertscher Patrick, du Fay de Lavallaz Jeanne, Marbot Stella, Sazgary Lorraine, Bolliger Daniel, Rentsch Katharina, Twerenbold Raphael, Hammerer-Lercher Angelika, Melo Edielle S, Calderaro Daniela, Duarte Alberto JS, de Luccia Nelson, Caramelli Bruno, Mueller Christian (2018), Comparison of high-sensitivity cardiac troponin I and T for the prediction of cardiac complications after non-cardiac surgery, in American Heart Journal
, 203, 67-73.
Puelacher Christian, Lurati Buse Giovanna, Seeberger Daniela, Sazgary Lorraine, Marbot Stella, Lampart Andreas, Espinola Jaqueline, Kindler Christoph, Hammerer Angelika, Seeberger Esther, Strebel Ivo, Wildi Karin, Twerenbold Raphael, du Fay de Lavallaz Jeanne, Steiner Luzius, Gurke Lorenz, Breidthardt Tobias, Rentsch Katharina, Buser Andreas, Gualandro Danielle M., Osswald Stefan, Mueller Christian, Seeberger Manfred (2018), Perioperative Myocardial Injury After Noncardiac SurgeryIncidence, Mortality, and Characterization, in Circulation
, 137(12), 1221-1232.
Sazgary Lorraine, PuelacherChristian, Lurati BuseGiovanna, GlarnerNoemi, LampartAndreas, BolligerDaniel, SteinerLuzius, GürkeLorenz, WolffThomas, MujagicEdin, SchaerenStefan, LardinoisDidier, EspinolaJacqueline, KindlerChristoph, Hammerer-LercherAngelika, StrebelIvo, WildiKarin, HidvegiReka, GueckelJohanna, HollensteinChristina, BreidthardtTobias, RentschKatharina, BuserAndreas, GualandroDanielle, MuellerChristian, Incidence of major adverse cardiac events following non-cardiac surgery, in European Heart Journal
Background: Worldwide, over 300 million major operations are performed annually. Despite advances in many fields of medicine, there is still a relevant risk of death related to these operations. Depending on how sick the patient was prior to the operation and the type of the operation needed, between 1% and 10% of patients die within 30 days of an operation. Cardiac complications, including a heart attack, occurring either during or immediately after these operations seem to be important contributors to many of these deaths.Most heart attacks occurring during or immediately after an operation do not cause symptoms such as chest pain, as the patients is receiving high doses of anesthetic drugs at this time. Accordingly, these heart attacks are very often missed in clinical routine. Therefore, it is largely unknown how often these heart attacks occur and for how many of the perioperative deaths these heart attacks are responsible for.Also, it is unknown, why these heart attacks occur during or immediately after an operation and how these patients should be treated.Aims: To find out, how common cardiac complications including heart attacks are during or immediately after an operation, for how many of the perioperative deaths these heart attacks are responsible for,why these heart attacks occur, how these patients should be treated.Methodology: 3460 consecutive patients undergoing a major operation will be included into this pragmatic prospective observational multicentre study at the University Hospital Basel, the Cantonal Hospital Aarau, and other hospitals in Switzerland. The study will be conducted by an interdisciplinary team of cardiology, anaesthesiology, and surgery. Patients will receive measurements of a novel blood tests that allows the rapid detection of dying heart muscle cells, and therefore heart attacks. prior to the operation, as well as after the operation. The type and the most likely cause of these heart attacks will then by examined by experienced physicians. We will contact all patients after hospital discharge and check whether they are fine or whether a complications or even death may have occurred. We will then try to develop tools that allow a more precise assessment of the risk in the individual patient developing such a cardiac complication and/or death.Potential Significance: Our large interdisciplinary multicentre project will provide novel and unique insights on heart attacks occurring during or immediately after an operation. These insights will empower physicians and patients to make better assessment of the risk-benefit ratio of a planned operation. E.g. patients being told that a planned operation carries with it for them a high risk of developing a heart attack may ultimately decide against an operation and chose a conservative treatment option.