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Supporting Lesotho on the way towards the UNAIDS 90-90-90 targets: Operational and clinical research addressing HIV/AIDS care in resource-limited settings

English title Supporting Lesotho on the way towards the UNAIDS 90-90-90 targets: Operational and clinical research addressing HIV/AIDS care in resource-limited settings
Applicant Amstutz Alain
Number 177576
Funding scheme MD-PhD fellowships (funded by SNSF)
Research institution
Institution of higher education University of Basel - BS
Main discipline Tropical Medicine
Start/End 01.12.2017 - 30.11.2020
Approved amount 180'000.00
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All Disciplines (2)

Discipline
Tropical Medicine
Internal Medicine

Keywords (6)

HIV/AIDS; Randomized Clinical Trial; resource-lmitted setting; Lesotho; Southern Africa; UNAIDS 90-90-90

Responsible applicant and co-applicants

Publications

Publication
VIBRA trial – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho
Amstutz Alain, Lejone Thabo Ishmael, Khesa Lefu, Muhairwe Josephine, Nsakala Bienvenu Lengo, Tlali Katleho, Bresser Moniek, Tediosi Fabrizio, Kopo Mathebe, Kao Mpho, Klimkait Thomas, Battegay Manuel, Glass Tracy Renée, Labhardt Niklaus Daniel (2019), VIBRA trial – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho, in Trials, 20(1), 522-522.
The HOSENG trial – Effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on testing coverage: protocol of a cluster-randomized clinical trial in rural Lesotho
Amstutz Alain, Lejone Thabo Ishmael, Khesa Lefu, Muhairwe Josephine, Nsakala Bienvenu Lengo, Tlali Katleho, Bresser Moniek, Vanobberghen Fiona, Kopo Mathebe, Kao Mpho, Klimkait Thomas, Battegay Manuel, Labhardt Niklaus Daniel, Glass Tracy Renée (2019), The HOSENG trial – Effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on testing coverage: protocol of a cluster-randomized clinical trial in rural Lesotho, in Trials, 20(1), 496-496.
Effect and cost of two successive home visits to increase HIV testing coverage: a prospective study in Lesotho, Southern Africa
Labhardt Niklaus Daniel, Ringera Isaac, Lejone Thabo Ishmael, Amstutz Alain, Klimkait Thomas, Muhairwe Josephine, Glass Tracy Renee (2019), Effect and cost of two successive home visits to increase HIV testing coverage: a prospective study in Lesotho, Southern Africa, in BMC Public Health, 19(1), 1441-1441.
Engagement in care, viral suppression, drug resistance and reasons for non-engagement after home-based same-day ART initiation in Lesotho: a two-year follow-up of the CASCADE trial
Amstutz Alain, Brown Jennifer Anne, Ringera Isaac, Muhairwe Josephine, Lejone Thabo Ishmael, Klimkait Thomas, Glass Tracy Renée, Labhardt Niklaus Daniel (2019), Engagement in care, viral suppression, drug resistance and reasons for non-engagement after home-based same-day ART initiation in Lesotho: a two-year follow-up of the CASCADE trial, in Clinical Infectious Diseases, 0.
The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho
Glass Tracy Renee, Motaboli Lipontso, Nsakala Bienvenu, Lerotholi Malebanye, Vanobberghen Fiona, Amstutz Alain, Lejone Thabo Ishmael, Muhairwe Josephine, Klimkait Thomas, Labhardt Niklaus Daniel (2019), The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho, in PLOS ONE, 14(8), e0220337-e0220337.
SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa
Amstutz Alain, Nsakala Bienvenu Lengo, Vanobberghen Fiona, Muhairwe Josephine, Glass Tracy Renée, Achieng Beatrice, Sepeka Mamorena, Tlali Katleho, Sao Lebohang, Thin Kyaw, Klimkait Thomas, Battegay Manuel, Labhardt Niklaus Daniel (2018), SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa, in BMC Infectious Diseases, 18(1), 76-76.
Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in LesothoThe CASCADE Randomized Clinical Trial
Labhardt Niklaus D., Ringera Isaac, Lejone Thabo I., Klimkait Thomas, Muhairwe Josephine, Amstutz Alain, Glass Tracy R. (2018), Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in LesothoThe CASCADE Randomized Clinical Trial, in JAMA, 319(11), 1103-1103.
Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: a retrospective cohort study
AmstutzAlain, SchandelmaierStefan, FreiRoy, AgarwalArnav, AlturkiReem, Von NiederhäusernBelinda, Von ElmErik, BrielMatthias (2018), Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: a retrospective cohort study, in Swiss Medical Weekly, 148(34), N/A.
Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study
Amstutz Alain, Schandelmaier Stefan, Frei Roy, Surina Jakub, Agarwal Arnav, Olu Kelechi Kalu, Alturki Reem, Von Niederhäusern Belinda, Von Elm Erik, Briel Matthias (2017), Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study, in BMJ Open, 7(7), e016216-e016216.

Collaboration

Group / person Country
Types of collaboration
Universität Basel, Departement Biomedizin, Prof. Klimkait Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
- Industry/business/other use-inspired collaboration
SolidarMed Lesotho, Dr Josephine Muhairwe Lesotho (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Ministry of Health, Lesotho Lesotho (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Industry/business/other use-inspired collaboration

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
International Workshop on HIV & Adolescence, International AIDS Society 2019 Talk given at a conference Oral self-testing for adolescents and young adults absent or refusing to test during home-based HIV testing – a mixed-method study embedded in a cluster-randomized trial in Lesotho (ADORE study) 03.10.2019 Nairobi, Kenya Amstutz Alain;
Global Health Session of the Joint Annual Meeting 2019 of SGI, SGInf, SGSH, SGTP, SGTRM 2019 Talk given at a conference Tackling the challenges of decentralized HIV testing and care in Southern Africa- two interlinked cluster-randomized trials in rural Lesotho 18.09.2019 Lausanne, Switzerland Amstutz Alain;
European Conference of Tropical Medicine and International Health 2019 Talk given at a conference HIV/AIDS-related knowledge and stigma among village health workers in rural Lesotho, Southern Africa: Analysis of data from GET ON research project 17.09.2019 Liverpool, Great Britain and Northern Ireland Amstutz Alain;
International AIDS Society Conference 2019 Poster Engagement in care, viral suppression, and reasons for non-engagement after home-based same-day ART initiation in Lesotho: a two-year follow-up of the CASCADE trial. 24.07.2019 Mexico City, Mexico Amstutz Alain;
CIPHER Stakeholder Meeting at IAS2019 Poster GET ON IT (“GETting tOwards Ninety In Teens”): A two-part research project with one cluster-randomized controlled trial assessing targeted interventions to reach the UNAIDS 90-90-90 targets among HIV-positive adolescents and young adults in rural Lesotho 23.07.2019 Mexico City, Mexico Amstutz Alain;
Research Forum Ministry of Health Lesotho 2019 Individual talk CASCADE 2-year follow-up: preliminary results 15.03.2019 Maseru, Lesotho Amstutz Alain;
Research Forum Ministry of Health Lesotho 2018 Individual talk SESOTHO study - preliminary results 17.10.2018 Maseru, Lesotho Amstutz Alain;
CIPHER Stakeholder Meeting at AIDS2018 Poster GET ON IT (“GETting tOwards Ninety In Teens”): A two-part research project with one cluster-randomized controlled trial assessing targeted interventions to reach the UNAIDS 90-90-90 targets among HIV-positive adolescents and young adults in rural Lesotho 22.07.2018 Amsterdam, AIDS2018, Netherlands Amstutz Alain;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media HIV/AIDS Epidemic What is needed for the final sprint? Bulletin of the Netherlands Society for Tropical Medicine and International Health, No04 / Volume57 International 2019
Media relations: print media, online media Zuhause statt im Gesundheitszentrum: HIV-Tests erreichen die Bergbevölkerung. SolidarMed Fokus, 19/1 03.2019 International German-speaking Switzerland 2019
New media (web, blogs, podcasts, news feeds etc.) CIPHER Grant für Dr. Alain Amstutz an der AIDS 2018 „Get on“ in Lesotho Medicus Mundi Schweiz Western Switzerland Italian-speaking Switzerland Rhaeto-Romanic Switzerland German-speaking Switzerland 2018
New media (web, blogs, podcasts, news feeds etc.) GET ON project homepage webpage International 2018
Video/Film IAS 2018: Alain Amstutz International 2018

Awards

Title Year
Grantee of the alternative HEMMI prize (10’000 CHF): Das GET ON Forschungspro-jekt: Dezentralisierung von HIV-Diagnostik und -Behandlung im südlichen Afrika – zwei miteinander verknüpfte cluster-randomisierte klinische Studien im ländlichen Lesotho 2019
Grantee of the 2018 CIPHER grant by the International AIDS Society (150’000 USD): GET ON IT (GETting tOwards Ninety In Teens) A two-part research project with one cluster-randomized controlled trial assessing targeted interventions to reach the UN-AIDS 90-90-90 targets among HIV-positive adolescents and young adults in rural Lesotho, Southern Africa. 2018

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