Project

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3D printing manufacturing of patient-tailored drug releasing stents

Applicant Leroux Jean-Christophe
Number 177178
Funding scheme Sinergia
Research institution Institut für Pharmazeutische Wissenschaften ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Interdisciplinary
Start/End 01.09.2018 - 31.08.2022
Approved amount 2'364'948.00
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All Disciplines (4)

Discipline
Interdisciplinary
Material Sciences
Biomedical Engineering
Pharmacology, Pharmacy

Keywords (4)

3D Printing; Drug Delivery; Airway Stents; Personalized medicine

Lay Summary (French)

Lead
Bien que l’impression tridimensionnelle (impression 3D) soit appelée à jouer un rôle important en médecine, l’absence de matériaux adéquats pour la production de dispositifs médicaux par ce procédé freine considérablement son développement. Le projet apporte une solution à ce problème.
Lay summary

Contenu et objectifs du travail de recherche

Au cours des dernières années, l’impression 3D a connu un essor considérable dans des domaines d’application variés allant de l’aéronautique aux sciences pharmaceutiques. L’objectif principal de ce programme de recherche Sinergia consiste à développer et exploiter plus avant une technique d’impression 3D appelée la stéréolithographie, pour la production de dispositifs médicaux contenant des médicaments. Un des avantages majeurs de ce procédé est la possibilité de générer avec une grande précision des structures complexes adaptées aux besoins du patient.  Pour atteindre cet objectif, il est nécessaire, dans un premier temps, de mettre au point et de caractériser de façon approfondie les biomatériaux qui permettront l’impression 3D de ces dispositifs médicaux. Dans une deuxième phase, les matériaux générés serviront à la production et à l’évaluation préclinique de prototypes de prothèses trachéales. De telles prothèses sont utilisées en clinique pour le traitement de l’obstruction des voies respiratoires pouvant survenir lors d’accidents, d’infections, de maladies congénitales ou de cancer. L’impression 3D de prothèses trachéales biocompatibles, parfaitement adaptées à l’anatomie du patient et capables de libérer de manière contrôlée un ou plusieurs médicaments représenterait un progrès considérable par rapport aux modalités thérapeutiques actuellement disponibles.

 

Contexte scientifique et social du projet de recherche

Ce projet relève de la recherche fondamentale (développement et caractérisation de nouveaux matériaux pour impression 3D) et appliquée (production de prototypes de dispositifs médicaux innovants). Il vise à étendre l’énorme potentiel de l’impression 3D au domaine biomédical.

Direct link to Lay Summary Last update: 01.12.2017

Responsible applicant and co-applicants

Employees

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
SSC/SSCS SSP/SSTS Joint Annual Meeting 2020 Talk given at a conference Development of an Animal Model to Induce Airway Stenosis and the Placement of a 3D Printed Airway Stent 23.09.2020 Bern, Switzerland Bao Yinyin; Kronen Peter; Geks Anna; Paunovic Nevena; Coulter Fergal; Franzen Daniel; Studart André R.; Kleger Nicole Suzanne; Klein Karina; Rüber Fabienne Alessandra; Leroux Jean-Christophe;
Invited seminar Individual talk Engineering Biodegradable Polymers for 3D Printing of Personalized Medical Devices 11.03.2020 ETH, Switzerland Bao Yinyin;
Invited seminar Individual talk Engineering Synthetic Polymers for Biomedical 3D Printing 03.01.2020 Tsinghua University, China Bao Yinyin;
The POLYDAYS 2019 conference Talk given at a conference The Development of Bioresorbable Personalized Airway Stents by Digital Light Processing 11.09.2019 Berlin, Germany Geks Anna; Franzen Daniel; Coulter Fergal; Paunovic Nevena; Kleger Nicole Suzanne; Klein Karina; Bao Yinyin; Kronen Peter; Leroux Jean-Christophe; Studart André R.;
2019 Fall Meeting of the Swiss Chemical Society Talk given at a conference 3D Printing of Personalized Biodegradable Airway Stents via Vat Photopolymerization 06.09.2019 Zurich, Switzerland Geks Anna; Leroux Jean-Christophe; Coulter Fergal; Klein Karina; Kronen Peter; Studart André R.; Paunovic Nevena; Kleger Nicole Suzanne; Franzen Daniel; Bao Yinyin;
Swiss Galenic Meeting 2019 Talk given at a conference Fabrication of Personalized Bioresorbable Airway Stents by 3D Printing 29.08.2019 Basel, Switzerland Paunovic Nevena; Studart André R.; Franzen Daniel; Klein Karina; Kronen Peter; Coulter Fergal; Kleger Nicole Suzanne; Bao Yinyin; Geks Anna; Leroux Jean-Christophe;
12th Swiss Pharma Science Day Poster Development of Personalized Biodegradable Airway Stents by 3D Printing 28.08.2019 Bern, Switzerland Franzen Daniel; Klein Karina; Paunovic Nevena; Coulter Fergal; Studart André R.; Bao Yinyin; Kleger Nicole Suzanne; Geks Anna; Leroux Jean-Christophe; Kronen Peter;
ETH MaP Graduate Symposium 2019 Poster Polymeric Materials for 3D printing of Personalized Biodegradable Airway stents 03.07.2019 Zurich, Switzerland Geks Anna; Studart André R.; Paunovic Nevena; Bao Yinyin; Coulter Fergal; Klein Karina; Franzen Daniel; Kronen Peter; Kleger Nicole Suzanne; Leroux Jean-Christophe;
Elsevier Frontiers in Polymer Science Talk given at a conference 3D Printing of Biodegradable Personalized Biomedical Devices 05.05.2019 Budapest, Hungary Bao Yinyin; Geks Anna; Paunovic Nevena; Coulter Fergal; Klein Karina; Kronen Peter; Kleger Nicole Suzanne; Franzen Daniel; Leroux Jean-Christophe; Studart André R.;
11th Swiss Chemical Industry Symposium Poster New Materials for 3D Printing of Biodegradable Personalized Airway Stents 24.01.2019 Zürich, Switzerland Geks Anna; Paunovic Nevena; Leroux Jean-Christophe; Studart André R.; Bao Yinyin; Franzen Daniel; Klein Karina; Kleger Nicole Suzanne; Kronen Peter; Coulter Fergal;


Awards

Title Year
Best oral presentation at SSC/SSCS SSP/SSTS Joint Annual Meeting 2020 2020
Best poster award (1st place) at ETH MaP graduate symposium 2020 2019

Abstract

There is a unique opportunity for innovation in medical sciences with the ongoing three-dimensional (3D) printing revolution. We propose to translate and advance one of the main 3D printing technologies, namely stereolithography (SLA), as platform to manufacture innovative drug-eluting devices with unprecedented customizability. The technologies’ versatility will enable selecting the drug, the dose loaded and the release kinetics, as well as tailoring the size and geometry of the device to completely accommodate the anatomic features and medical needs of patients. To achieve this, we will expand the available range of printable, biocompatible materials that can endure the printing and post-processing conditions, and we will establish manufacturing and characterization guidelines. For this purpose, we will explore the fabrication of drug-eluting tracheal stent for the treatment of airways stenosis, which can arise due to a number of causes including accidental compression, intubation-related injuries, congenital malformations, infections, inflammatory diseases and malignant or benign tumors. The device prototypes will carry relevant model drugs with anti-proliferative or anti-microbial properties. They will be produced in an iterative process of printable material development, 3D prototype design and fabrication, in vitro characterization and in vivo evaluation. Through this process, we will generate a library of printable “pharmaceutical inks”, a comprehensive database of their properties and the procedures that can be used to 3D print and characterize drug-delivering devices as well as test their performances in relevant animal models. To achieve this ambitious goal, this Sinergia project will bring together three key Swiss laboratories with outstanding experience in drug delivery, material sciences, preclinical experimentation and clinical studies. Notably, the output of this project will be translatable to other devices and medical applications, as well as other 3D printing technologies. Demonstrating the feasibility of customizing drug-eluting devices through 3D printing would represent a seminal contribution to personalized medicine, where the “one-size-fits-all” approach could be soon replaced by a truly patient-tailored one. This highly interdisciplinary project has no contender in Switzerland and will set the basis for appointing the Country at the forefront of stents manufacturing and pharma-3D printing technologies.
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