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Evaluation of environmental impacts in water ecosystems with genetic based bacteriological and physicochemical aspects guided sustainable water resource management in developing countries; Case of south India and sub-Saharan Africa

English title Evaluation of environmental impacts in water ecosystems with genetic based bacteriological and physicochemical aspects guided sustainable water resource management in developing countries; Case of south India and sub-Saharan Africa
Applicant Poté Wembonyama John
Number 173281
Funding scheme Project funding (Div. I-III)
Research institution Institut F.-A. Forel Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Medical Microbiology
Start/End 01.10.2017 - 28.02.2019
Approved amount 110'549.00
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All Disciplines (2)

Discipline
Medical Microbiology
Molecular Biology

Keywords (6)

strengthening the capacity - India - Congo DR; Hospital effluents - latrines - open water ecosyst; soil sediment - heavy metals and organic pollutant; latrine and wells, bacterial diversity, - pathogen; pyrosequencing - antibiotic resistance, ; raw vegetables, - human risks, - water resource

Lay Summary (French)

Lead
Le sol et l’environnement aquatique ont récemment été considérés comme réservoirs majeurs de bactéries et de gènes de résistance aux antibiotiques. Les taux élevés de résistance retrouvés dans l’environnement sont considérés comme la conséquence de l'utilisation intensive des antibiotiques en milieu hospitalier et vétérinaire. Pour ce projet, nous évaluons les impacts potentiels de cette problématique sur l’environnement et la santé de la population exposée. La recherche est menée en condition climatique tropicale dans les pays en voie de développement, spécifiquement en Inde et en République Démocratique du Congo.
Lay summary

Les stations d'épuration des eaux usées sont considérées comme les sources majeures de la dissémination dans l’environnement des bactéries et des gènes de résistance aux antibiotiques. La situation est plus préoccupante dans les grandes villes des pays d’Asie du sud, d’Amérique du sud et de l’Afrique sub-Saharienne. Dans la plupart de ces pays, les eaux usées et les rejets hospitaliers sont directement déversés dans les rivières sans traitement préalable. Les rivières et les nappes phréatiques recevant ces effluents sont souvent utilisées comme eaux de consommation, de baignade ainsi que pour l’irrigation des cultures maraîchères. L’obtention des données quantitatives provenant du compartiment aquatique est indispensable, afin de définir les mesures à prendre en vue de réduire l’augmentation de la résistance aux antibiotiques dans l'environnement et prévenir leur impact sur la santé humaine. Dans le cadre de cette étude, nous proposons (i) la détection et la quantification des bactéries et gènes de résistance aux antibiotiques dans les rivières contaminées par les effluents urbain et hospitalier ainsi que dans les produits issus des cultures utilisant ces eaux pour l’irrigation, et (ii) l’évaluation des risques pour la santé humaine et la mise en place de possibilités de remédiation. La recherche est menée en Inde et en République Démocratique du Congo. Les méthodes et les scénarios qui seront développés comprendront entre autres les stratégies pour le développement d’une nouvelle pratique de gestion de l'eau et de production alimentaire durable, ainsi que la prévention des risques pour la santé humaine.

Direct link to Lay Summary Last update: 27.04.2017

Responsible applicant and co-applicants

Employees

Name Institute

Project partner

Publications

Publication
Prevalence of water-related diseases and groundwater (drinking-water) contamination in the suburban municipality of Mont Ngafula, Kinshasa (Democratic Republic of the Congo)
Kapembo Michel L., Al Salah Dhafer Mohammed M., Thevenon Florian, Laffite Amandine, Bokolo Mathieu K., Mulaji Crispin K., Mpiana Pius T., Poté John (2019), Prevalence of water-related diseases and groundwater (drinking-water) contamination in the suburban municipality of Mont Ngafula, Kinshasa (Democratic Republic of the Congo), in Journal of Environmental Science and Health, Part A, 1-11.
Prevalence of β-Lactam and Sulfonamide Resistance Genes in a Freshwater Reservoir, Lake Brêt, Switzerland
Laffite Amandine, Al Salah Dhafer Mohammed M., Slaveykova Vera I., Poté John (2019), Prevalence of β-Lactam and Sulfonamide Resistance Genes in a Freshwater Reservoir, Lake Brêt, Switzerland, in Exposure and Health, 0.
Concentration of toxic metals and potential risk assessment in edible fishes from Congo River in urbanized area of Kinshasa, DR Congo
Mata Henry K., Periyasamy Sivalinga, Konde Joel, Otamonga Jean-Paul, Niane Birane, Mulaji Crispin K., Kiyombo Guillaume M., Poté John (2019), Concentration of toxic metals and potential risk assessment in edible fishes from Congo River in urbanized area of Kinshasa, DR Congo, in Human and Ecological Risk Assessment: An International Journal , 0.
Effect of untreated urban effluents on the accumulation of toxic metals in river sediments under tropical conditions: Funa River, Kinshasa, Democratic Republic of the CongoEffect of untreated urban effluents on the accumulation of toxic metals
Kayembe John M., Bokwokwo Merveille I., Sivalingam Periyasamy, Ngelinkoto Patience, Otamonga Jean-Paul, Mulaji Crispin K., Mubedi Josué I., Poté John (2018), Effect of untreated urban effluents on the accumulation of toxic metals in river sediments under tropical conditions: Funa River, Kinshasa, Democratic Republic of the CongoEffect of untreated urban effluents on the accumulation of toxic metals, in Water and Environment Journal, 0.
Assessment of water quality and time accumulation of heavy metals in the sediments of tropical urban rivers: Case of Bumbu River and Kokolo Canal, Kinshasa City, Democratic Republic of the Congo
Kayembe John M., Sivalingam Periyasamy, Salgado Carmen Diz, Maliani Jeff, Ngelinkoto Patience, Otamonga Jean-Paul, Mulaji Crispin K., Mubedi Josué I., Poté John (2018), Assessment of water quality and time accumulation of heavy metals in the sediments of tropical urban rivers: Case of Bumbu River and Kokolo Canal, Kinshasa City, Democratic Republic of the Congo, in Journal of African Earth Sciences, 147, 536-543.
Concentration of heavy metals in edible fishes from Atlantic Coast of Muanda, Democratic Republic of the Congo
Suami Robert B., Sivalingam Periyasamy, Kabala César D., Otamonga J.-P., Mulaji Crispin K., Mpiana Pius T., Poté John (2018), Concentration of heavy metals in edible fishes from Atlantic Coast of Muanda, Democratic Republic of the Congo, in Journal of Food Composition and Analysis, 73, 1-9.
High levels of faecal contamination in drinking groundwater and recreational water due to poor sanitation, in the sub-rural neighbourhoods of Kinshasa, Democratic Republic of the Congo
Kayembe John M., Thevenon Florian, Laffite Amandine, Sivalingam Periyasamy, Ngelinkoto Patience, Mulaji Crispin K., Otamonga Jean-Paul, Mubedi Josué I., Poté John (2018), High levels of faecal contamination in drinking groundwater and recreational water due to poor sanitation, in the sub-rural neighbourhoods of Kinshasa, Democratic Republic of the Congo, in International Journal of Hygiene and Environmental Health, 221(3), 400-408.
High contamination in the areas surrounding abandoned mines and mining activities: An impact assessment of the Dilala, Luilu and Mpingiri Rivers, Democratic Republic of the Congo
Atibu Emmanuel K., Lacroix Pierre, Sivalingam Periyasamy, Ray Nicolas, Giuliani Gregory, Mulaji Crispin K., Otamonga Jean-Paul, Mpiana Pius T., Slaveykova Vera I., Poté John (2018), High contamination in the areas surrounding abandoned mines and mining activities: An impact assessment of the Dilala, Luilu and Mpingiri Rivers, Democratic Republic of the Congo, in Chemosphere, 191, 1008-1020.

Collaboration

Group / person Country
Types of collaboration
Prof. Xavier Bertrand, CHRU Besançon France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
National Pedagogical University of Congo, Faculty of Science Congo Democratic Republic (formerly Zaire) (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
University of Kinshasa, Faculty of Science and Faculty of Medecine Congo Democratic Republic (formerly Zaire) (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Prof. Vera Slaveykova Forel department Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Stephan Harbarth, Hôpitaux Universitaires de Genève Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Swiss Microbial Ecology 2019 Talk given at a conference Effect of agricultural landscape on the dissemination of β-lactams and sulfonamides resistance genes in the lake of Brêt, Switzerland 04.12.2018 Aquatis Conference Center, Lausanne, Switzerland, Switzerland Laffite Amandine; Poté Wembonyama John;
33° Congreso Latinoamericano de Química. X Congreso de Ciencias, Tecnología e Innovación Química Talk given at a conference Historical pollution and dissemination of micropollutants, pathogens and antibiotic resistance according to the country’s degree of development and different climate conditions 12.10.2018 La Havana, Cuba Laffite Amandine; Poté Wembonyama John;
Setac Europe 28th Annual Meeting Talk given at a conference ESBLECs carrying multidrug resistance and virulence factors in tropical rivers receiving hospital effluents 16.05.2018 Rome Convention Centre La Nuvola, Rome, Italy, Italy Laffite Amandine;


Knowledge transfer events



Self-organised

Title Date Place
Antibiorésistance en Afrique Sub-saharienne: Bon usage des antibiotiques en république démocratique du Congo 12.11.2018 University of Kinshasa, Congo Democratic Republic (formerly Zaire)
Séminaire sur la diffusion des Polluants et des bactéries de résistances aux antibiotiques en milieux aqueux 20.06.2018 University of Kinshasa, Congo Democratic Republic (formerly Zaire)
La résistance aux antibiotiques augmente: La République Démocratique du Congo s’engage 17.11.2017 University of Kinshasa, Congo Democratic Republic (formerly Zaire)

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Atelier sur la résistance aux antibiotiques Agence catholique de presse Congo (DIA) International 2018
Talks/events/exhibitions Demi-journée du personnel direction générale de la santé sur l'antibiorésistance (DGS) Western Switzerland 2018
Media relations: print media, online media Le PRCERSE échange sur les antibiotiques et résistances antimicrobiennes Agence Congo Presse (Digital Congo) International 2018
Media relations: radio, television Les causes environnementales liées à la résistance aux antibiotiques RTS Suisse Western Switzerland 2018
Talks/events/exhibitions Semaine mondiale pour un bon usage des antibiotiques 2018 Western Switzerland 2018
Talks/events/exhibitions Semaine mondiale pour un bon usage des antibiotiques 2017 Western Switzerland 2017

Awards

Title Year
The organizing committee acknowledges for the best talk during the 33° Latino-American Congress of Chemistry, CLAQ for the following presentation: Exploring Research in Aquatic Ecosystem: Historical pollution and dissemination of micropollutants, pathogens and antibiotic resistance according to the country’s degree of development and different climate conditions 2018

Associated projects

Number Title Start Funding scheme
150163 Evaluation of environmental impacts in water ecosystems with genetic based bacteriological and physicochemical aspects guided sustainable water resource management in developing countries; Case of south India and sub-Saharan Africa 01.05.2014 Project funding (Div. I-III)

Abstract

Building and strengthening of capacity in developing countries can be considered as one of major aspects of sustainable development in the World. The challenging water contamination, natural resources management as well as food production have the global consequences. For this proposal, the approaches are chosen to identify the most critical problems related to water contamination in general, particularly in developing countries such as India and Democratic Republic of the Congo (DRC). The general purpose of this research is to study the effect of hospital effluents on the distribution and prevalence of antibiotic resistant bacteria (ARB) and their resistance genes from the surface waters and sediments of river receiving systems under tropical conditions, and the impact of population and latrines on faecal contamination in ponds and wells will be assessed. Both aspects are highly relevant from a global perspective for the economic, social and environmental development throughout the world. This project also examines the environmental exposure pathways particularly anthropogenic influences associated with aquatic environment receiving systems, irrigation water and crops, and drinking water supplies. The methods and scenarios developed include the potential strategy for the development of new sustainable water management and food production as well as to prevent the human risks in Asia and Sub-Sahara Africa. It should be noted that the present application constitutes the continuation of the research project funded by SNSF (Grant no. 31003A_150163/1). The project is performed at University of Geneva in collaboration with Jamal Mohamed College (Bharathidasan University, India) and two University of Kinshasa (UNIKIN and UPN), DRC. The project implicates one postdoc from India working at University of Geneva, 4 PhD students at university of Kinshasa(DRC) and 2 PhD students at University of Geneva. Here, we ask for the extension of the PhD thesis (Amandine Laffite, at University of Geneva, faculty of sciences) until September 30, 2018 (12 months of salary), which will correspond to full 4 years in total. The present application concerns important and complementary aspects to permit us to fulfil the remaining scientist goals of the project relatively to different implicated parties. The different scenarios are/will be performed to assess the levels and factors that influence the concentrations and transfers of pathogens into rivers and its associated agricultural irrigation lands to prevent public health risks. This proposal is of great interest for regional and global researches regarding the human-aquatic environment interaction. Strengthening the capacity, facilitating the integration of scientists in the international network as well as stimulation of an active dialog between researchers/experts and stakeholders in Switzerland, DRC and India dealing with issues related with the human and environmental impacts and water management are other major outcomes of the project. Workshops and seminars are organizing by applicants to disseminate the knowledge to public for the sustainable water management to stand with global community to combat drug resistant pathogens.
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