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A Paradigm Shift in Magnetic Resonance Imaging of the Heart: 5D Imaging - Sample Now and Ask Questions Later

English title A Paradigm Shift in Magnetic Resonance Imaging of the Heart: 5D Imaging - Sample Now and Ask Questions Later
Applicant Stuber Matthias
Number 173129
Funding scheme Project funding (Div. I-III)
Research institution Département de radiologie médicale Centre Hospitalier Universitaire Vaudois University of Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Cardiovascular Research
Start/End 01.06.2017 - 31.05.2021
Approved amount 937'652.00
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All Disciplines (2)

Discipline
Cardiovascular Research
Physiology : other topics

Keywords (6)

Compressed Sensing; Free-Running Imaging; 5D imaging; Ventricular Function; Cardiac Magnetic Resonance Imaging; Coronary Artery Anatomy

Lay Summary (German)

Lead
Magnetic resonance imaging enables a safe, non-invasive, assessment of the heart without radiation. It can quantify blood flow, function, and tissue characteristics. However, significant aspects of cardiac MRI have remained unchanged over the past decades, highly specialized personnel is needed, and acquisition is time consuming. To remove these hurdles, we propose to break away from the decades-old paradigm where data are collected in a prospectively triggered fashion, and propose instead to sample image data continuously and irrespective of the heart’s position and contractile state. This can be achieved by combining in depth knowledge of Mathematics, Engineering and Physics. This research will lead to shorter exams for the patient and to more detailed information about the heart muscle and its vessels for the clinician. This translational and interdisciplinary research is conducted in strong collaboration with medical professionals at the CHUV.
Lay summary

Magnetresonanz Tomographie ist ein nichtinvasives bildgebendes Verfahren welches keine Risiken birgt, und das ohne potenziell schädliche Röntgenstrahlung auskommt. Damit ist es möglich den Herzmuskel und dessen Gefäße abzubilden - und den Blutfluss und die Kontraktion zu messen.  Leider ist das Verfahren bis heute kompliziert, dauert lange, und speziell ausgebildetes Fachpersonal ist notwendig um diese Daten zu erfassen. Das hat damit zu tun dass die angewendeten Techniken über mehrere Jahrzehnte hinweg mehr oder weniger unverändert geblieben sind. Dank neuen Verfahren die am CHUV entwickelt wurden, und dank neueren Erkenntnissen aus der Mathematik, der Physik, den Ingenieur- und Computerwissenschaften sind wir nun in der Lage eine Lösung vorzuschlagen, welche das Verfahren massiv vereinfacht, welche zu kürzeren Messzeiten für den Patienten führt, und welche dem Arzt bessere Informationen über den Zustand des Herzmuskels und dessen Gefäßen liefern wird. Diese fächerübergreifende Forschung wird in Zusammenarbeit von Wissenschaftlern und Medizinischem Fachpersonal am CHUV durchgeführt.

Direct link to Lay Summary Last update: 08.05.2017

Responsible applicant and co-applicants

Employees

Publications

Publication
Using 5D flow MRI to decode the effects of rhythm on left atrial 3D flow dynamics in patients with atrial fibrillation
Ma Liliana, Yerly Jérôme, Di Sopra Lorenzo, Piccini Davide, Lee Jeesoo, DiCarlo Amanda, Passman Rod, Greenland Philip, Kim Daniel, Stuber Matthias, Markl Michael (2021), Using 5D flow MRI to decode the effects of rhythm on left atrial 3D flow dynamics in patients with atrial fibrillation, in Magnetic Resonance in Medicine, mrm.28642-mrm.28642.
5D Flow MRI: A Fully Self-gated, Free-running Framework for Cardiac and Respiratory Motion–resolved 3D Hemodynamics
Ma Liliana E., Yerly Jérôme, Piccini Davide, Di Sopra Lorenzo, Roy Christopher W., Carr James C., Rigsby Cynthia K., Kim Daniel, Stuber Matthias, Markl Michael (2020), 5D Flow MRI: A Fully Self-gated, Free-running Framework for Cardiac and Respiratory Motion–resolved 3D Hemodynamics, in Radiology: Cardiothoracic Imaging, 2(6), e200219-e200219.
3-Dimensional magnetic resonance imaging of the freely moving human eye
Franceschiello Benedetta, Di Sopra Lorenzo, Minier Astrid, Ionta Silvio, Zeugin David, Notter Michael P., Bastiaansen Jessica A.M., Jorge João, Yerly Jérôme, Stuber Matthias, Murray Micah M. (2020), 3-Dimensional magnetic resonance imaging of the freely moving human eye, in Progress in Neurobiology, 194, 101885-101885.
Deep Learning to Automate Reference-Free Image Quality Assessment of Whole-Heart MR Images
Piccini Davide, Demesmaeker Robin, Heerfordt John, Yerly Jérôme, Di Sopra Lorenzo, Masci Pier Giorgio, Schwitter Juerg, Van De Ville Dimitri, Richiardi Jonas, Kober Tobias, Stuber Matthias (2020), Deep Learning to Automate Reference-Free Image Quality Assessment of Whole-Heart MR Images, in Radiology: Artificial Intelligence, 2(3), e190123-e190123.
Free‐running 5D coronary MR angiography at 1.5T using LIBRE water excitation pulses
Masala Nemanja, Bastiaansen Jessica A. M., Di Sopra Lorenzo, Roy Christopher W., Piccini Davide, Yerly Jérôme, Colotti Roberto, Stuber Matthias (2020), Free‐running 5D coronary MR angiography at 1.5T using LIBRE water excitation pulses, in Magnetic Resonance in Medicine, mrm.28221-mrm.28221.
A quantitative comparison between a navigated Cartesian and a self‐navigated radial protocol from clinical studies for free‐breathing 3D whole‐heart bSSFP coronary MRA
Heerfordt John, Stuber Matthias, Maillot Aurélien, Bianchi Veronica, Piccini Davide (2019), A quantitative comparison between a navigated Cartesian and a self‐navigated radial protocol from clinical studies for free‐breathing 3D whole‐heart bSSFP coronary MRA, in Magnetic Resonance in Medicine, mrm.28101-mrm.28101.
Natively fat‐suppressed 5D whole‐heart MRI with a radial free‐running fast‐interrupted steady‐state (FISS) sequence at 1.5T and 3T
Bastiaansen Jessica A.M., Piccini Davide, Di Sopra Lorenzo, Roy Christopher W., Heerfordt John, Edelman Robert R., Koktzoglou Ioannis, Yerly Jérôme, Stuber Matthias (2019), Natively fat‐suppressed 5D whole‐heart MRI with a radial free‐running fast‐interrupted steady‐state (FISS) sequence at 1.5T and 3T, in Magnetic Resonance in Medicine, 83(1), 45-55.
An automated approach to fully self‐gated free‐running cardiac and respiratory motion‐resolved 5D whole‐heart MRI
Di Sopra Lorenzo, Piccini Davide, Coppo Simone, Stuber Matthias, Yerly Jérôme (2019), An automated approach to fully self‐gated free‐running cardiac and respiratory motion‐resolved 5D whole‐heart MRI, in Magnetic Resonance in Medicine, 82(6), 2118-2132.

Collaboration

Group / person Country
Types of collaboration
Medical University of South Carolina United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Emory University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Northwestern University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Karolinska Institute Sweden (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Children's Hospital of Philadelphia United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Liryc - L'institut De Rythmologie Et Modélisation Cardiaque France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Mie University Japan (Asia)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Society for Cardiovascular Magnetic Resonance Poster Study on the potential acceleration of ferumoxytol-enhanced free-running 5D whole-heart MRI in pediatric patients 12.02.2020 Orlando Florida, United States of America Di Sopra Lorenzo; Stuber Matthias; Roy Christopher;
Society for Cardiovascular Magnetic Resonance Poster Auto-focusing for three-dimensional motion corrected free-breathing whole-heart coronary Magnetic Resonance Angiography 12.02.2020 Orlando Florida, United States of America Roy Christopher; Stuber Matthias; Schwitter Jürg;
Society for Cardiovascular Magnetic Resonance Talk given at a conference 5D flow MRI for cardiac and respiratory motion-resolved 3D blood flow dynamics in adult patients and pediatric patients with congenital heart disease 12.02.2020 Orlando Florida, United States of America Roy Christopher; Stuber Matthias; Di Sopra Lorenzo;
Society for Cardiovascular Magnetic Resonance Poster 5D Flow MRI using Pilot Tone for Cardiac and Respiratory Self-Gating 12.02.2020 Orlando Florida, United States of America Roy Christopher; Stuber Matthias; Di Sopra Lorenzo; Baginha Da Lanca Falcao Mariana;
Society for Cardiovascular Magnetic Resonance Talk given at a conference Performance Analysis of a Fully Automatic Real-Time Capable Pilot Tone Cardiac Triggering Framework 12.02.2020 Orlando Florida, United States of America Stuber Matthias;
Society for Cardiovascular Magnetic Resonance Talk given at a conference Measuring Ejection Fraction in Reformatted 5D Image Data Acquired with Free-Running Whole-Heart MRI 12.02.2020 Orlando Florida, United States of America Di Sopra Lorenzo; Stuber Matthias;
Society for Magnetic Resonance Angiography Talk given at a conference 5D flow MRI for Cardiac and Respiratory Motion-resolved 3D hemodynamics using Gadoterate Meglumine and Ferumoxytol 27.08.2019 Nantes, France Stuber Matthias; Roy Christopher; Di Sopra Lorenzo;
Society for Magnetic Resonance Angiography Talk given at a conference A Similarity-Based Data Clustering Approach for Fast Reconstruction of Untriggered and Ungated Whole-Heart MRA 27.08.2019 Nantes, France Stuber Matthias; Roy Christopher; Di Sopra Lorenzo;
The International Society for Magnetic Resonance in Medicine Poster Large-scale image quality assessment using deep learning: impact of physiological factors and acquisition settings in whole-heart coronary MRA 11.05.2019 Montreal, Canada Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster Respiratory Motion Signals Extracted from 3D Image-Based Navigation and from PCA of SI-Projections: Initial Findings in Whole-Heart Imaging using a Free-Running Framework 11.05.2019 Montreal, Canada Stuber Matthias; Di Sopra Lorenzo; Roy Christopher;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Natively Fat-Suppressed Fast Interrupted Steady State (FISS) for 5D Whole Heart Imaging at 1.5 and 3T 11.05.2019 Montreal, Canada Di Sopra Lorenzo; Stuber Matthias; Roy Christopher;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Cardiovascular MR: Technical Promises 11.05.2019 Montreal, Canada Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Fat-free free-running coronary MRA at 1.5T using LIBRE water excitation pulses 11.05.2019 Montreal, Canada Di Sopra Lorenzo; Stuber Matthias; Roy Christopher;
The International Society for Magnetic Resonance in Medicine Poster Automated Image Quality Assessment in 5D Whole-Heart MRI Aimed at Guiding Readers of High-Dimensional Dynamic Imaging 11.05.2019 Montreal, Canada Di Sopra Lorenzo; Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster Fully Self-Gated Cardiac and Respiratory Motion-Resolved 5D MRI for Rapid Assessment of Left Ventricular Function 11.05.2019 Montreal, Canada Stuber Matthias; Schwitter Jürg; Di Sopra Lorenzo;
The International Society for Magnetic Resonance in Medicine Poster Four-dimensional whole-heart cine imaging with isotropic resolution in one single breath-hold: initial results 11.05.2019 Montreal, Canada Schwitter Jürg; Di Sopra Lorenzo; Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster Cardiac and Respiratory Motion-Resolved 5D Imaging Using a Free-Running Framework: Comparison of Cartesian and Radial Trajectories 11.05.2019 Montreal, Canada Roy Christopher; Di Sopra Lorenzo; Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference 5D flow MRI: A free-running, fully self-gated, radial imaging framework for cardiac and respiratory motion-resolved assessment of 3D blood flow dynamics 11.05.2019 Montreal, Canada Stuber Matthias; Di Sopra Lorenzo; Roy Christopher;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Fully Self-Gated Cardiac and Respiratory Motion-Resolved Isotropic 5D T1 Mapping of the Heart: Preliminary Results 11.05.2019 Montreal, Canada Stuber Matthias; Di Sopra Lorenzo; Roy Christopher;
Society for Cardiovascular Magnetic Resonance Poster Fat suppression in 3D bSSFP coronary MRA using lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulses 06.02.2019 Bellevue Washington, United States of America Stuber Matthias; Roy Christopher; Di Sopra Lorenzo;
Society for Cardiovascular Magnetic Resonance Talk given at a conference A Comparison of Respiratory Self-Gating Methods using Automated Image Quality Assessment: A Proof of Concept in Coronary MRA 06.02.2019 Bellevue Washington, United States of America Stuber Matthias; Di Sopra Lorenzo;
Society for Cardiovascular Magnetic Resonance Poster 5D flow MRI: A free-running, self-gated, radial imaging framework for cardiac and respiratory motion-resolved assessment of 3D blood flow dynamics 06.02.2019 Bellevue Washington, United States of America Di Sopra Lorenzo; Roy Christopher; Stuber Matthias;
Society for Magnetic Resonance Angiography Talk given at a conference Deep Learning meets Compressed Sensing: Image Quality-Regularized Coronary MRA 28.08.2018 Glasgow, Great Britain and Northern Ireland Stuber Matthias;
Society for Magnetic Resonance Angiography Talk given at a conference Deep Learning for Automated Reference-Free Image Quality Assessment of Whole-Heart Magnetic Resonance Images 28.08.2018 Glasgow, Great Britain and Northern Ireland Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Towards 3D & 4D Comprehensive CMR 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster Pilot Tone Navigation Enables Contactless Prospective Cardiac Triggering: Initial Volunteer Results for Prospective Cine 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster Deep Learning for Automated Medical Image Quality Assessment: Proof of Concept in Whole-Heart Magnetic Resonance Imaging 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference A Phantom Study to Compare the Theoretical Accuracy and Precision of CT Angiography versus Radial MRI for the Assessment of Coronary Endothelial Function 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster Model-Based Lag Free Processing of Pilot Tone Navigator Data Enables Prospective Cardiac Triggering 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Poster A Simple Method for Post-Processing Correction of 3D Radial Trajectory Imperfections in 5D Cardiac MRI 16.06.2018 Paris, France Di Sopra Lorenzo; Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Automated Coil Ranking using a Neural Network for Image Quality Assessment - An Explorative Study in Coronary MRI 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Automated Coil Ranking using a Neural Network for Image Quality Assessment: An Explorative Study in Coronary MRI 16.06.2018 Paris, France Stuber Matthias;
The International Society for Magnetic Resonance in Medicine Talk given at a conference Lipid-insensitive 4D motion-resolved free breathing coronary MRA in heart transplant recipients at 3T 16.06.2018 Paris, France Di Sopra Lorenzo; Stuber Matthias;
Swiss Congress of Radiology Talk given at a conference Navigator-Gated Cartesian Versus Self-Navigated Radial Free-Breathing 3D bSSFP Coronary MRA: A Quantitative Comparison in Healthy Volunteers 10.05.2018 Lausanne, Switzerland Stuber Matthias;
Swiss Congress of Radiology Talk given at a conference Deep Learning for Automated Medical Image Quality Assessment: Application to Whole-Heart Magnetic Resonance Imaging 10.05.2018 Lausanne, Switzerland Stuber Matthias;
Swiss Congress of Radiology Poster Coronary MRA in heart transplant recipients at 3T 10.05.2018 Lausanne, Switzerland Stuber Matthias; Di Sopra Lorenzo;
Swiss Congress of Radiology Talk given at a conference Motion-Resolved 5D MR Imaging of the Heart: A Simple Correction for Radial Trajectory Imperfections 10.05.2018 Lausanne, Switzerland Di Sopra Lorenzo; Stuber Matthias;
Swiss Congress of Radiology Poster Quantifying Cardiac Allograft Vasculopathy with Magnetic Resonance Imaging versus Optical Coherence Tomography 10.05.2018 Lausanne, Switzerland Bianchi Veronica; Stuber Matthias;
Swiss Congress of Radiology Poster CT Angiography versus Radial MRI: Theoretical Accuracy and Precision of Cross-Sectional Area Measurements for the Assessment of Coronary Endothelial Function 10.05.2018 Lausanne, Switzerland Stuber Matthias;
Society for Cardiovascular Magnetic Resonance Talk given at a conference A quantitative comparison of navigator-gated Cartesian and self-navigated radial freebreathing 3D bSSFP whole-heart coronary MRA 03.03.2018 Barcelona, Spain Stuber Matthias; Bianchi Veronica;
Society for Cardiovascular Magnetic Resonance Talk given at a conference Motion-resolved free-breathing coronary MRA in heart transplant recipients at 3T 31.01.2018 Barcelona, Spain Di Sopra Lorenzo; Stuber Matthias;
Society for Magnetic Resonance Angiography Talk given at a conference Automated Cardiac Resting Phase Detection in 2D cine MR images for Acquisition Window Selection in Coronary MRI: Preliminary Results 03.10.2017 Cape Town, South Africa Stuber Matthias;
Society for Magnetic Resonance Angiography Talk given at a conference Fully Self-Gated Push-Button Non-Contrast 5D Imaging of the Heart 03.10.2017 Cape Town, South Africa Di Sopra Lorenzo; Stuber Matthias;
Society for Magnetic Resonance Angiography Talk given at a conference Exploring Binning Strategies for Respiratory Motion-Resolved Coronary MRA in Patients 03.10.2017 Cape Town, South Africa Stuber Matthias; Di Sopra Lorenzo;


Self-organised

Title Date Place
CIBM-CHUV-MR Retreat 05.09.2019 Sévrier - Lac d'Annecy, France
CIBM-CHUV-MR Retreat 05.09.2018 Sévrier - Lac d'Annecy, France
CIBM-CHUV-MR Retreat 30.08.2017 Sévrier - Lac d'Annecy, France

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Magnetic Resonance in Medicine Highlights Online Interview International 2020

Awards

Title Year
Gold Medal Award of the Society for Cardiovascular Magnetic Resonance (SCMR), the highest distinction in cardiovascular MRI, has been bestowed to Matthias Stuber at the annual meeting of the society in February 2021. 2021
Junior Fellow Award of the International Society for Magnetic Resonance in Medicine (ISMRM) 2020
Master of SCMR 2020
Society for Cardiovascular Magnetic Resonance Travel Award 2020
Society for Cardiovascular Magnetic Resonance Travel Award 2020
Top 10% of downloaded articles in Magn Reson Med for Jessica Bastiaansen (https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27942) 2020
Top 10% of downloaded articles in Magn Reson Med for Lorenzo Di Sopra (https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27898) 2020
President of the Society for Cardiovascular Magnetic Resonance Prof. Stuber has been a member of the executive committee of the SCMR for five years, and his Presidency of this international Society began in February 2018 and ended one year later. 2019
Society for Magnetic Resonance Angiography Poetchen Award won by John Heerfordt 2019
The International Society for Magnetic Resonance in Medicine Magna Cum Laude Award won by Liliana Ma 2019
The International Society for Magnetic Resonance in Medicine Magna Cum Laude Award won by Nemanja Masala 2019
Fellow of the SCMR 2018
Outstanding Teacher Award ISMRM for presenting work related to this grant. 2018

Associated projects

Number Title Start Funding scheme
143923 Non-invasive and Regional 3D Measures of Coronary Vasomotor Function, Delayed Hyperenhancement and Vessel Wall Plaque Characteristics in Early Atherosclerosis Using Advanced High-Field Magnetic Resonance Imaging 01.03.2013 Project funding (Div. I-III)
163050 Assessing cardiac metabolic pathways and inflammatory responses in the ischemic-reperfused myocardium using hyperpolarized 13C metabolic MR spectroscopy and 19F-MR macrophage imaging 01.05.2016 Project funding (Div. I-III)
159727 Reappraisal of glucose-insulin-potassium therapy in acute st-segment elevation myocardial infarction by pre-hospital administration (reagik-stemi) 01.06.2015 Project funding (Div. I-III)
169191 Gender differences in renal disease progression: an analysis of potential mechanisms using modern radiological techniques. 01.10.2016 Project funding (Div. I-III)

Abstract

Significant aspects of cardiac MRI data acquisition strategies have largely remained unchanged over the past two decades, highly specialized personnel is needed to ensure quality, and data acquisition remains time consuming. In a deliberate attempt to remove these hurdles, we propose to break away from the decades-old paradigm where data are collected in a prospectively triggered and gated fashion and propose instead to sample image data uninterrupted, continuously, without triggering or gating, and irrespective of the heart’s position and contractile state. Based on our strong preliminary developments both on the data acquisition and reconstruction side, we posit that the combination of a free-running imaging sequence and compressed sensing reconstruction leads to 5D imaging, a new paradigm where the image that best answers to a clinical question is extracted retrospectively after the scan. This will translate to an improved ease-of-use of cardiac MRI and the opportunity to collect not only more but also more precise information about the heart per unit time. As this relates to uncharted territory to a large degree, a focused research effort from which we will learn how to best apply these new concepts, from which we will learn about the degree of success, and from which we will also learn at which point success meets failure, is now critically important. In the pursuit of that ambitious goal, a series of elaborate components need to be integrated and tested. At the CHUV, our team consisting of scientists and engineers has developed a number of such components that can be leveraged: 1.) a free-running 4D imaging sequence, 2.) a flexible compressed sensing reconstruction framework that enables respiratory motion correction without the need for navigators, breath-holding, or self-navigation, 3.) a short spectrally selective water excitation radiofrequency pulse that supports highly effective fat signal suppression without interrupting steady-state, and 4.), a framework that extracts both cardiac and respiratory motion signals directly from the continuously acquired image data. A tried and tested team of interdisciplinary researchers that includes basic scientists and medical professionals proposes here to logically and mechanistically integrate these components, to leverage new developments and concepts, to rigorously research strengths and weaknesses, to learn about optimal parameter ranges and algorithms, to translate this potentially transformative technology to the in vivo setting, and to finally study the performance in clinical patients using gold standard comparisons.
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