sensory coding; ensemble plasticity; olfaction; two-photon imaging
Bhattacharjee Anindya S., Konakamchi Sasank, Turaev Dmitrij, Vincis Roberto, Nunes Daniel, Dingankar Atharva A., Spors Hartwig, Carleton Alan, Kuner Thomas, Abraham Nixon M. (2019), Similarity and Strength of Glomerular Odor Representations Define a Neural Metric of Sniff-Invariant Discrimination Time, in Cell Reports
, 28(11), 2966-2978.e5.
Marissal Thomas, Salazar Rodrigo F., Bertollini Cristina, Mutel Sophie, De Roo Mathias, Rodriguez Ivan, Müller Dominique, Carleton Alan (2018), Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia, in Nature Neuroscience
, 21(10), 1412-1420.
Dietschi Quentin, Tuberosa Joël, Rösingh Lone, Loichot Gregory, Ruedi Manuel, Carleton Alan, Rodriguez Ivan (2017), Evolution of immune chemoreceptors into sensors of the outside world, in Proceedings of the National Academy of Sciences
, 114(28), 7397-7402.
Yamada Yoshiyuki, Bhaukaurally Khaleel, Madarász Tamás J., Pouget Alexandre, Rodriguez Ivan, Carleton Alan (2017), Context- and Output Layer-Dependent Long-Term Ensemble Plasticity in a Sensory Circuit, in Neuron
, 93(5), 1198-1212.e5.
Sensory information is conveyed to specialized brain circuits and is translated into ensemble representations by various populations of projection neurons. Whether different channels of output neurons could form similar and stable representations in diverse behavioral contexts remains largely unknown. We propose to study the olfactory bulb (OB), where two layers of output neurons, mitral and tufted cells, jointly receive odorant information in glomerulus and in turn project to different target cortical regions. We propose to use chronic two-photon calcium imaging in awake behaving mice to first test whether both output populations display similar odor response profiles. Then, we aim at testing whether ensemble odor representations following either passive sensory experience or active associative learning are subjected to daily reorganization. Furthermore, we would like to test whether mitral and tufted cells populations are subjected to the same forms of plasticity. Finally, our last goal would be to identify the circuit mechanisms possibly underlying different forms of plasticity. In summary, the results of this research project should allow testing whether different OB output layers display unique context-dependent long-term ensemble plasticity and whether different OB output layers may allow parallel transfer of non-redundant sensory information to distinct downstream centers.